Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (2): 110-114.doi: 10.12016/j.issn.2096-1456.2019.02.009

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Research progress on extracellular vesicles and bone regeneration

WEI Shimin1,WANG Yuanjing1,HUANG Wen1,QU Yili1,2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China;
    2. Departmenr of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-05-13 Revised:2018-06-10 Online:2019-02-20 Published:2019-02-21
  • Contact: Yili QU E-mail:qqyili@126.com

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Abstract:

Extracellular vesicles (EVs) are lipid bilayers secreted by a variety of cells that contain nucleic acids, proteins, etc. They can be used as a carrier for cell-to-cell communication. In related research on bone regeneration, mechanisms for transmitting regeneration signals to target cells to achieve the desired goal of osteogenesis have become one of the most important and unsolved topics. Therefore, this review aims to explore the role of mesenchymal stem cells and EVs derived from osteoblasts in bone regeneration in four processes, immunity, angiogenesis, osteogenesis and mineralization, and to provide new ideas for basic and clinical research.

Key words: Extracellular vesicles, Exosomes, Matrix vesicles, Mesenchymal stem cell, Bone regeneration, Angiogenesis, Mineralization

CLC Number: 

  • R681.3
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