Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (2): 110-114.doi: 10.12016/j.issn.2096-1456.2019.02.009

• Review Articles • Previous Articles     Next Articles

Research progress on extracellular vesicles and bone regeneration

WEI Shimin1,WANG Yuanjing1,HUANG Wen1,QU Yili1,2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China;
    2. Departmenr of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-05-13 Revised:2018-06-10 Online:2019-02-20 Published:2019-02-21
  • Contact: Yili QU E-mail:qqyili@126.com

Abstract:

Extracellular vesicles (EVs) are lipid bilayers secreted by a variety of cells that contain nucleic acids, proteins, etc. They can be used as a carrier for cell-to-cell communication. In related research on bone regeneration, mechanisms for transmitting regeneration signals to target cells to achieve the desired goal of osteogenesis have become one of the most important and unsolved topics. Therefore, this review aims to explore the role of mesenchymal stem cells and EVs derived from osteoblasts in bone regeneration in four processes, immunity, angiogenesis, osteogenesis and mineralization, and to provide new ideas for basic and clinical research.

Key words: Extracellular vesicles, Exosomes, Matrix vesicles, Mesenchymal stem cell, Bone regeneration, Angiogenesis, Mineralization

CLC Number: 

  • R681.3
[1] Fischer UM, Harting MT, Jimenez F , et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect[J]. Stem Cells Dev, 2009,18(5):683-692.
doi: 10.1089/scd.2008.0253
[2] Coyne TM, Marcus AJ, Reynolds K , et al. Disparate host response and donor survival after the transplantation of mesenchymal or neuroectodermal cells to the intact rodent brain[J]. Transplantation, 2007,84(11):1507-1516.
doi: 10.1097/01.tp.0000288185.09601.4d pmid: 18091528
[3] Yue Y, Garikipati VNS, Verma SK , et al. Interleukin-10 deficiency impairs reparative properties of bone marrow-derived endothelial progenitor cell exosomes[J]. Tissue Eng Part A, 2017,23(21/22):1241-1250.
doi: 10.1089/ten.TEA.2017.0084 pmid: 28471299
[4] Mahamutha Affshana M, Priya J . Healing mechanism in bone fracture[J]. J Pharm Pharm Sci, 2015,7(7):441-442.
[5] Marsell R, Einhorn TA . The biology of fracture healing[J]. Injury, 2011,42(6):551-555.
doi: 10.1016/j.injury.2011.03.031 pmid: 21489527
[6] Rilla K, Mustonen AM, Arasu UT , et al. Extracellular vesicles are integral and functional components of the extracellular matrix[J]. Matrix Biol, 2017. doi: 10.1016/j.matbio.2017.10.003.
doi: 10.1016/j.matbio.2017.10.003 pmid: 29066152
[7] Lai RC, Yeo RW, Tan KH , et al. Exosomes for drug delivery - a novel application for the mesenchymal stem cell[J]. Biotechnol Adv, 2013,31(5):543-551.
doi: 10.1016/j.biotechadv.2012.08.008 pmid: 22959595
[8] Hugel B, Martínez MC, Kunzelmann C , et al. Membrane microparticles: two sides of the coin[J]. Physiology (Bethesda), 2005,20:22-27.
doi: 10.1152/physiol.00029.2004 pmid: 15653836
[9] Turturici G, Tinnirello R, Sconzo G , et al. Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages[J]. Am J Physiol Cell Physiol, 2014,306(7):C621-C633.
doi: 10.1152/ajpcell.00228.2013 pmid: 24452373
[10] Tkach M, Théry C . Communication by extracellular vesicles: where we are and where we need to go[J]. Cell, 2016,164(6):1226-1232.
doi: 10.1016/j.cell.2016.01.043
[11] Liu M, Sun Y, Zhang Q . Emerging role of extracellular vesicles in bone remodeling[J]. J Dent Res, 2018,97(8):859-868.
doi: 10.1177/0022034518764411 pmid: 29566346
[12] Mcbride JD, Rodriguez-Menocal L, Badiavas EV . Extracellular vesicles as biomarkers and therapeutics in dermatology: a focus on exosomes[J]. J Invest Dermatol, 2017,137(8):1622-1629.
doi: 10.1016/j.jid.2017.04.021 pmid: 28648952
[13] Ko J, Bhagwat N, Yee SS , et al. Combining machine learning and nanofluidic technology to diagnose pancreatic cancer using exosomes[J]. ACS Nano, 2017,11(11):11182-11193.
doi: 10.1021/acsnano.7b05503 pmid: 29019651
[14] Zhou L, Lv T, Zhang Q , et al. The biology, function and clinical implications of exosomes in lung cancer[J]. Cancer Lett, 2017,407:84-92.
doi: 10.1016/j.canlet.2017.08.003 pmid: 28807820
[15] Wang J, Yeung BZ, Cui M , et al. Exosome is a mechanism of intercellular drug transfer: application of quantitative pharmacology[J]. J Control Release, 2017,268:147-158.
doi: 10.1016/j.jconrel.2017.10.020 pmid: 29054369
[16] Malda J, Boere J, Van De Lest CH , et al. Extracellular vesicles — new tool for joint repair and regeneration[J]. Nat Rev Rheumatol, 2016,12(4):243-249.
doi: 10.1038/nrrheum.2015.170 pmid: 26729461
[17] Robbins PD, Dorronsoro A, Booker CN . Regulation of chronic inflammatory and immune processes by extracellular vesicles[J]. J Clin Invest, 2016,126(4):1173-1180.
doi: 10.1172/JCI81131 pmid: 27035808
[18] Deregibus MC, Cantaluppi V, Calogero R , et al. Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA[J]. Blood, 2007,110(7):2440-2448.
doi: 10.1182/blood-2007-03-078709 pmid: 17536014
[19] Huang JH, Yin XM, Xu Y , et al. Systemic administration of exosomes released from mesenchymal stromal cells attenuates apoptosis, inflammation, and promotes angiogenesis after spinal cord injury in rats[J]. J Neurotrauma, 2017,34(24):3388-3396.
doi: 10.1089/neu.2017.5063 pmid: 28665182
[20] Zhang B, Yin Y, Lai RC , et al. Mesenchymal stem cells secrete immunologically active exosomes[J]. Stem Cells Dev, 2014,23(11):1233-1244.
doi: 10.1089/scd.2013.0479 pmid: 24367916
[21] Ismail N, Wang Y, Dakhlallah D , et al. Macrophage microvesicles induce macrophage differentiation and miR-223 transfer[J]. Blood, 2013,121(6):984-995.
doi: 10.1182/blood-2011-08-374793
[22] Chu CY, Deng J, Sun XC , et al. Collagen membrane and immune response in guided bone regeneration: recent progress and perspectives[J]. Tissue Eng Part B Rev, 2017,23(5):421-435.
doi: 10.1089/ten.TEB.2016.0463 pmid: 28372518
[23] Yu S, Liu C, Su K , et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells[J]. J Immunol, 2007,178(11):6867-6875.
doi: 10.1016/j.diamond.2009.01.006 pmid: 17513735
[24] Arslan F, Lai RC, Smeets MB , et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury[J]. Stem Cell Res, 2013,10(3):301-312.
doi: 10.1016/j.scr.2013.01.002 pmid: 23399448
[25] Hankenson KD, Dishowitz M, Gray C , et al. Angiogenesis in bone regeneration[J]. Injury, 2011,42(6):556-561.
doi: 10.1016/j.injury.2011.03.035
[26] Bian SY, Zhang LP, Duan LF , et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model[J]. J Mol Med-JMM, 2014,92(4):387-397.
doi: 10.1007/s00109-013-1110-5
[27] Lopatina T, Bruno S, Tetta C , et al. Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential[J]. Cell Commu Signal, 2014,12(1):26.
doi: 10.1186/1478-811X-12-26 pmid: 24725987
[28] Xie H, Wang Z, Zhang L , et al. Extracellular vesicle-functionalized decalcified bone matrix scaffolds with enhanced pro-angiogenic and pro-bone regeneration activities[J]. Sci Rep, 2017,7:45622.
doi: 10.1038/srep45622 pmid: 28367979
[29] Liu XL, Li Q, Niu X , et al. Exosomes secreted from human-induced pluripotent stem cell-derived mesenchymal stem cells prevent osteonecrosis of the femoral head by promoting angiogenesis[J]. Int J Biol Sci, 2017,13(2):232-244.
doi: 10.7150/ijbs.16951 pmid: 28255275
[30] Gangadaran P, Rajendran RL, Lee HW , et al. Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia[J]. J Control Release, 2017,264:112-126.
doi: 10.1016/j.jconrel.2017.08.022 pmid: 28837823
[31] Narayanan R, Huang CC, Ravindran S . Hijacking the cellular mail: exosome mediated differentiation of mesenchymal stem cells[J]. Stem Cells Int, 2016: 3808674.
doi: 10.1155/2016/3808674 pmid: 26880957
[32] Zhang S, Chu WC, Lai RC , et al. Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration[J]. Osteoarthr Cartilage, 2016,24(12):2135-2140.
doi: 10.1016/j.joca.2016.06.022 pmid: 27390028
[33] Vonk LA, Van Dooremalen SFJ, Liv N , et al. Mesenchymal stromal/stem cell-derived extracellular vesicles promote human cartilage regeneration in vitro[J]. Theranostics, 2018,8(4):906-920.
doi: 10.7150/thno.20746 pmid: 29463990
[34] Xie Y, Chen Y, Zhang L , et al. The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling[J]. J Cell Mol Med, 2017,21(5):1033-1041.
doi: 10.1111/jcmm.13039 pmid: 27878944
[35] Ge M, Ke R, Cai T , et al. Identification and proteomic analysis of osteoblast-derived exosomes[J]. Biochem Biophys Res Commun, 2015,467(1):27-32.
doi: 10.1016/j.bbrc.2015.09.135 pmid: 26420226
[36] Qin YH, Wang L, Gao ZL , et al. Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo[J]. Sci Rep, 2016,6:21961.
doi: 10.1038/srep21961 pmid: 4766421
[37] Lu Z, Chen Y, Dunstan C , et al. Priming adipose stem cells with tumor necrosis factor-alpha preconditioning potentiates their exosome efficacy for bone regeneration[J]. Tissue Eng Part A, 2017,23(21/22):1212-1220.
doi: 10.1089/ten.tea.2016.0548 pmid: 28346798
[38] Zhong Z, Ethen NJ, Williams BO . WNT signaling in bone development and homeostasis[J]. Wiley Interdiscip Rev Dev Biol, 2014,3(6):489-500.
doi: 10.1002/wdev.159 pmid: 25270716
[39] Li W, Liu Y, Zhang P , et al. Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration[J]. ACS Appl Mater Interfaces, 2018,10(6):5240-5254.
doi: 10.1021/acsami.7b17620 pmid: 29359912
[40] Nurbaeva MK, Eckstein M, Feske S , et al. Ca 2+ transport and signalling in enamel cells [J]. J Physiol, 2017,595(10):3015-3039.
doi: 10.1113/JP272775
[41] Tintut Y, Patel J, Territo M , et al. Monocyte/macrophage regulation of vascular calcification in vitro[J]. Circulation, 2002,105(5):650-655.
doi: 10.1161/hc0502.102969 pmid: 11827934
[42] New SE, Goettsch C, Aikawa MA , et al. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques[J]. Circ Res, 2013,113(1):72-77.
doi: 10.1161/CIRCRESAHA.113.301036
[43] Nguyen MA, Karunakaran D, Geoffrion M , et al. Extracellular vesicles secreted by atherogenic macrophages transfer microRNA to inhibit cell migration[J]. Arterioscler Thromb Vasc Biol, 2018,38(1):49-63.
doi: 10.1161/ATVBAHA.117.309795 pmid: 28882869
[44] Kapustin AN, Davies JD, Reynolds JL , et al. Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization[J]. Circ Res, 2011,109(1):E1-U41.
doi: 10.1161/RES.0b013e31822765d1
[45] Kapustin AN, Chatrou ML, Drozdov I , et al. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion[J]. Circ Res, 2015,116(8):1312-1323.
doi: 10.1161/CIRCRESAHA.116.305012
[46] Chen Q, Bei JJ, Liu C , et al. HMGB1 induces secretion of matrix vesicles by macrophages to enhance ectopic mineralization[J]. Plos One, 2016,11(5):e0156686.
doi: 10.1371/journal.pone.0156686 pmid: 27243975
[1] SONG Qun,LIU Xiaochen,MA Yuxuan,WANG Chenyu,JIAO Kai,NIU Lina. Biomimetic remineralization of dentin [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 383-389.
[2] XIAO Wenlan,HU Chen,RONG Sheng′an,QU Yili. Clinical application of autogenous dentin as a bone graft material [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 394-398.
[3] REN Lizhi,SUN Rui. New progress in the clinical application of GBR membrane materials [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 404-408.
[4] WANG Yamin,ZHOU Zhen,DAO Junfeng,CHEN Qiyue,LIU Wenjing,SONG Guangbao. Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(4): 236-240.
[5] XIAO Wenlan,HU Chen,RONG Shengan,ZHU Chenyou,WU Yingying. Application of dentin in bone tissue engineering [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(2): 127-130.
[6] YE Qingsong, HU Fengting, LUO Lihua, Maria Troulis. Research and application of stem cell-derived exosomes in regenerative medicine [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(1): 1-10.
[7] JIANG Xiaowen,HUANG Huaqing,CHEN Jinyong,PENG Haiyan. Experimental study of periostin promoting rapid distraction osteogenesis of the rabbit mandible [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(9): 551-556.
[8] LIU Ying,YANG Jing,LI Yazhen,YAN Xiao,ZHANG Qiang,REN Dapeng,YANG Fang,YUAN Xiao,GUO Qingyuan. Effects of silencing the HIF-1α gene on the expression of BSP and osterix in rat BMMSCs under tension [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(5): 287-292.
[9] HU Beibei,BAI Hai,JIA Wanping,LIANG Yongqiang. Remineralization effect of nanohydroxyapatite on adjacent glazed surfaces [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(4): 231-235.
[10] LIU Qian,LAN Lufang,YAN Junyi,TIAN Weidong,GUO Shujuan. Research on the surface structure of a dentin matrix with complete demineralization and incomplete demineralization and the osteogenic property promotion of human periodontal ligament cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(3): 159-166.
[11] HE Hongzhi,MA Dandan. Research progress on exosomes derived from dental pulp stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(10): 652-657.
[12] Renli YANG,Yuanjing WANG,Shimin WEI,Wen HUANG,Yufei WANG,Chenyou ZHU,Yili QU. Relationship between T cells and bone regeneration: recent progress and perspectives [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(9): 601-605.
[13] Xuening GU, Jiamiao QUAN, Yuqing GUO, Song LI. cAMP-responsive-element-binding protein promotes the differentiation of human stem cells from the apical papilla via inhibition of the TGF-β1 pathway [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 428-433.
[14] Shuangxi LIU, Shulan XU, Binping WANG, Zhuogeng CHEN. Effects of basic fibroblast growth factor combined with a collagen membrane on soft tissue defects vascularization in the hard palates of rats [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 440-444.
[15] Xiaohu XU, Xingzhu DAI, Wanghong ZHAO. Research progress on anticaries nanomaterials [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 472-476.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Hong-chang LAI,Jun-yu SHI. Maxillary sinus floor elevation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(1): 8 -12 .
[2] Pin ZHOU, Yang-fei LI. MRI study of temporomandibular joint disc position in asymptomatic volunteers[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(4): 239 -244 .
[3] Xinxin XIA, Fang FANG, Lijuan CHENG. Shaping ability of Pathfile and WaveOne in simulated root canals[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(6): 365 -368 .
[4] Yuanhong LI, Xinyi FANG, Yu QIU, Lei CHENG. Experimental study on the effects of green tea on salivary flow rate and pH value[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(9): 560 -564 .
[5] Chengzhang LI. Masticatory muscles in occlusion[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(12): 755 -760 .
[6] . [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(1): 1 .
[7] Zhirong WU, Shiguang Huang. Research progress on the etiology, clinical examination and treatment of peri-implantitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(6): 401 -405 .
[8] Xiaowu YAO, Shisheng CHEN, Zizheng LU, Minxiao LIN. Clinical report and literature review on the amyloidosis of salivary glands[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 533 -536 .
[9] Lan LIAO, Lijun ZENG. Updated research on digitalization in aesthetic restoration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 409 -414 .
[10] Yu LU, Chengxia LIU, Zhongjun LIU. Role of TRAF6 in inflammatory responses of human osteoblast-like cells with Enterococcusfaecalis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(7): 420 -425 .
This work is licensed under a Creative Commons Attribution 3.0 License.