Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (2): 115-121.doi: 10.12016/j.issn.2096-1456.2019.02.010

• Review Articles • Previous Articles     Next Articles

Research progress on the CD4 +T cell balance in oral cancer and precancerous diseases

TIAN Yuanye,TANG Zhangui()   

  1. Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Central South University, Changsha 410078, China
  • Received:2018-06-11 Revised:2018-07-17 Online:2019-02-20 Published:2019-02-21
  • Contact: Zhangui TANG E-mail:tangzhangui@aliyun.com

Abstract:

CD4 +T cells play an important role in regulating adaptive immune responses to various inflammatory responses. Parental T cell populations can differentiate in response to different cytokines into at least four subpopulations: Th1, Th2, Th17, and Treg cells. These differentiated T cells participate in various immune responses and have different roles and functions in oral cancer and precancerous diseases. The Th1/Th2 balance, the Th17/Treg balance and the occurrence and development of oral cancer and precancerous diseases are related to immune imbalances. Reversing these T cell imbalances and strengthening the patient’s autoimmune function may prevent or even reverse the progression of oral and precancerous diseases. This paper reviews the research advances on the CD4 +T cell balance in oral cancer and precancerous lesions.

Key words: Th1, Th2, Th17, Regulatory T cell, Oral squamous cell carcinoma, Oral precancerous lesion

CLC Number: 

  • R739.8
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