Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (4): 236-240.DOI: 10.12016/j.issn.2096-1456.2019.04.006

• Cinical Study • Previous Articles     Next Articles

Study on the correlation between common diseases of oral mucosa and psychological factors

LIN Lin,DUAN Ning,WANG Xiang,SONG Yuefeng,WANG Wenmei()   

  1. Department of oral mucosa disease, Nanjing Stomatological Hospital, Medical School of Nanjing University, Jiangsu Nanjing 210008, China.
  • Received:2018-11-19 Revised:2019-01-04 Online:2019-04-20 Published:2019-04-28
  • Contact: Wenmei WANG



  1. 南京大学医学院附属口腔医院,南京市口腔医院口腔黏膜病科,江苏 南京(210008)
  • 通讯作者: 王文梅
  • 作者简介:林琳,医师,硕士,
  • 基金资助:


Objective To explore the relationship between psychological factors and recurrent aphthous ulcer (RAU), oral lichen planus (OLP), and burning mouth syndrome (BMS) and to provide a reference for clinical diagnosis and treatment of the disease.Methods From July to October 2018, 50 patients with common RAU, refractory RAU, OLP and BMS were selected as the observation group, and 50 healthy participants without major systemic diseases and oral mucosal diseases matched for age and sex served as the control group. The psychological status of the subjects in each group was investigated by questionnaires, including the generalized anxiety disorder 7-item scale(GAD-7) and the patient health questionnaire-9 (PHQ-9).Results Compared with the control group, the PHQ-9 scores in the refractory RAU, common RAU, OLP and BMS groups were higher than those in the control group (P < 0.05), and the GAD-7 scores in the refractory RAU, OLP and BMS groups were higher than those in the control group (P < 0.05). In the RAU group, the GAD-7 score of intractable RAU was higher than that of common RAU (P < 0.05), and there was no significant difference in the PHQ-9 score (P > 0.05).Conclusion RAU, OLP and BMS are common psychosomatic diseases presented by patients in the Department of Oral Mucosal Diseases. Their occurrence and development are related to the psychological status of patients. A tendency toward anxiety is significantly more common among refractory RAU patients than common RAU patients.

Key words: Oral mucosa, Recurrent aphthous ulcer, Oral lichen planus, Burning?mouth?syndrome, Psychological factors, Anxiety, Depression


目的 探讨心理因素与复发性阿弗他溃疡(recurrent aphthous ulcer, RAU)、口腔扁平苔藓(oral lichen planus, OLP)、灼口综合征(burning? mouth? syndrome, BMS)的联系,为疾病的临床诊治提供参考。方法 选择2018年7—10月在南京大学医学院附属口腔医院口腔黏膜病科门诊就诊的普通性RAU、顽固性RAU、OLP、BMS患者各50例作为观察组,同时选择50名无重大系统性疾病和口腔黏膜疾病且年龄、性别等与试验组相匹配的健康人作为对照组。对各组研究对象分别进行问卷调查分析心理状态,包括广泛性焦虑障碍量表(the generalized anxiety disorder 7-item scale,GAD-7)及9项患者健康问卷表(patient health questionnare-9, PHQ-9)。结果 顽固性RAU、普通性RAU、OLP、BMS与对照组相比,PHQ-9的得分均高于对照组,差异有统计学意义(P < 0.05);顽固性RAU、OLP、BMS与对照组相比,GAD-7的得分高于对照组,差异有统计学意义(P < 0.05)。RAU组中,顽固性RAU的GAD-7得分高于普通性RAU,差异有统计学意义(P < 0.05),但PHQ-9得分差异无统计学意义(P>0.05)。结论 RAU、OLP、BMS作为口腔黏膜病科常见的心身疾病,其发生、发展与患者的心理状态有关系,顽固性RAU患者的焦虑倾向比普通性RAU患者显著。

关键词: 口腔黏膜, 复发性阿弗他溃疡, 口腔扁平苔藓, 灼口综合征, 心理因素, 焦虑, 抑郁

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