Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (4): 264-267.DOI: 10.12016/j.issn.2096-1456.2019.04.012

• Review Articles • Previous Articles     Next Articles

Research progress on the function and metabolism of d-alanine in bacteria

GUO Xiao,DU Xinmei,CHENG Lei,ZHOU Xuedong,LI Mingyun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Stomatology Hospital of Sichuan University, Chengdu 610041, China
  • Received:2018-05-27 Revised:2018-12-22 Online:2019-04-20 Published:2019-04-28
  • Contact: Mingyun LI

D-丙氨酸在细菌中的功能和代谢研究进展

郭笑,杜信眉,程磊,周学东,李明云()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院,四川 成都(610041)
  • 通讯作者: 李明云
  • 作者简介:郭笑,在读硕士研究生,Email:smileguo@163.com
  • 基金资助:
    国家自然科学基金项目(81400501);国家自然科学基金项目(81430011);口腔疾病研究国家重点实验室专项经费(SKLOD201525)

Abstract:

D-alanine is a chiral molecule of L-alanine that participates in the formation and regulation of cell wall peptidoglycans, phosphoteichoic acid, spore germination and respiratory metabolism in individual bacteria. D-alanine participates in the formation and regulation of biofilm in bacterial communities. The function and metabolism of D-alanine in bacteria are specific, and the enzymes and genes in its metabolic pathway can be used as drug targeting sites. In this paper, the synthesis, metabolism and function of D-alanine in bacteria were reviewed, and the relationship between D-alanine and pathogenicity of Streptococcus mutans was discussed to provide a theoretical basis for candidate targeting sites of anti-caries drugs. According to existing research results, the enzymes and related genes involved in D-alanine metabolism play important roles in the growth and biofilm formation of Streptococcus mutans, and D-alanine is expected to be a target for the design of anti-caries drugs.

Key words: D-alanine, Bacteria, Function, Metabolism, Dental caries, Targeted therapy

摘要:

D-丙氨酸是L-丙氨酸的手性分子,在细菌个体中参与细胞壁肽聚糖和磷壁酸等的构成以及孢子的出芽和呼吸代谢等过程; 在细菌群落中,D-丙氨酸参与生物膜的形成与调节。D-丙氨酸在细菌中的功能和代谢存在特异性,其代谢通路中的酶和基因可作为药物的靶向位点。本文对D-丙氨酸的合成,在细菌中的代谢及功能等方面的作用进行综述, 探讨D-丙氨酸与变异链球菌致病性的关系,以期为抗龋药物候选靶向位点提供理论基础。通过现有研究结果表明,D-丙氨酸代谢过程中的酶及相关基因在对变异链球菌的生长及生物膜形成具有重要作用,有望作为靶点设计抗龋药物。

关键词: D-丙氨酸, 细菌, 功能, 代谢, 龋病, 靶向治疗

CLC Number: