Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (5): 280-286.DOI: 10.12016/j.issn.2096-1456.2019.05.002

• Expert Forum • Previous Articles     Next Articles

Recent advances in the application of quaternary ammonium compounds in biomedical materials

JIAO Yang1,CHEN Jihua2,()   

  1. 1. Department of Stomatology, 7th Medical Center of PLA General Hospital, Beijing 100700, China
    2. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China;
  • Received:2018-11-22 Revised:2018-12-24 Online:2019-05-20 Published:2019-05-20
  • Contact: Jihua CHEN

季铵盐化合物在生物医学材料中的应用进展

焦阳1,陈吉华2,()   

  1. 1. 解放军总医院第七医学中心口腔科,北京(100700)
    2. 军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心, 陕西省口腔疾病重点实验室,空军军医大学口腔医院修复科,陕西 西安(710032)
  • 通讯作者: 陈吉华
  • 作者简介:陈吉华,空军军医大学教授,博士生导师,口腔修复学专家;教育部“长江学者”特聘教授;兼任中华口腔医学会副会长、IADR中国分会主席、中华口腔医学会口腔修复专委会主任委员等职。长期从事口腔修复学的临床、教学和科研工作,擅长口腔固定义齿修复,在口腔粘结技术、全瓷修复、高分子修复材料及仿生功能化材料研究方向上取得了显著成果。领衔团队获国家教育部优秀科技创新团队,主持教育部“创新团队发展计划”并获滚动支持、获国家自然科学基金重点项目和重大国际合作项目各1项、面上项目7项以及“973”前期专项等课题;发表SCI论文105篇,单篇最高影响因子38.89;获国家发明专利7项;获省部级科技奖一等奖2项,国家科技三等奖及军队成果二等奖各1项;主编、主译、副主编专著和教材9部;培养毕业研究生100余名;指导研究生获得全军优秀博士学位论文两项、硕士一项。
  • 基金资助:
    国家自然科学基金项目(81720108011,81470773);军事口腔医学国家重点实验室开放课题(2018KA02);长江学者及创新团队发展计划(IRT13051)

Abstract:

Microbial infections affect people worldwide. Quaternary ammonium salts serve antibacterial, antifungal, antiviral, anti-matrix metalloproteinase and polymerization functions. While the modification of biomaterials with quaternary ammonium salts cannot affect the physical or chemical properties of the biomaterials, this process can confer them with stable biological activity. Currently, quaternary ammonium salts are widely used in the development of functional orthopedic materials, sutures, dressings and dental materials, and the idea of modifying biomedical materials with quaternary ammonium salts has become the most promising, e.g., for preparing antimicrobial biomaterials. Recent studies have found that quaternary ammonium salt-modified antimicrobial monomers are cytotoxic. Therefore, it is of great significance to explore the cytotoxic mechanism of quaternary ammonium salt-modified antimicrobial monomers and determine possible cytoprotective measures for improving the biological safety of these antimicrobial resin-based materials and expanding their clinical applications. In addition, further validation of the clinical efficacy of these biomaterials is particularly important for accurately evaluating the clinical prospects of these biomaterials. Based on a literature review, this paper summarizes the applications and toxicity of biomedical materials modified with quaternary ammonium salts.

Key words: Quaternary ammonium compound, Antibacterial, Orthopedics-related materials, Sutures, Wound dressings, Dental materials, Cytotoxicity, Matrix metalloproteinase

摘要:

微生物感染影响着全世界的人类。季铵盐类化合物同时具有抗细菌、抗真菌、抗病毒和抗基质金属蛋白酶和聚合功能,利用其对生物材料进行改性可以在不影响材料本身理化性能的同时赋予其稳定的生物活性,目前被广泛应用于研制功能性骨科材料、缝合线、敷料和牙科材料,此思路成为最有前景的制备抗菌生物材料的策略之一。最近的研究发现,季铵盐型抗菌单体具有细胞毒性,因此,探究其细胞毒性机制并在此基础上寻找可能的细胞保护措施对改善抗菌树脂基材料的生物安全性、拓展其临床应用具有重大的意义。此外,进一步验证这些生物材料的临床有效性对于准确评估材料的临床应用前景尤为重要。本文将在文献回顾的基础上对季铵盐类化合物在生物医学材料中的应用进展及其生物毒性进行阐述。

关键词: 季铵盐, 抗菌性, 骨科材料, 缝合线, 敷料, 牙科材料, 细胞毒性, 基质金属蛋白酶

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