Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (7): 428-434.DOI: 10.12016/j.issn.2096-1456.2019.07.004
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Gang WANG1,Peng SUN2,Juan LI3,Shiguang HUANG3()
Received:
2018-10-30
Revised:
2019-04-26
Online:
2019-07-20
Published:
2019-07-24
Contact:
Shiguang HUANG
通讯作者:
黄世光
作者简介:
王刚,副主任医师,硕士,Email: 651814586@qq.com,
基金资助:
CLC Number:
Gang WANG,Peng SUN,Juan LI,Shiguang HUANG. Expression of the receptor of advanced glycation end products in gingival tissue endothelial cells from type 2 diabetic rats with chronic periodontitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(7): 428-434.
王刚,孙澎,李娟,黄世光. 晚期糖基化终产物受体在2型糖尿病伴慢性牙周炎大鼠牙龈组织内皮细胞中的表达[J]. 口腔疾病防治, 2019, 27(7): 428-434.
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大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 75.753 ± 5.382 | 41.253 ± 2.902 | 58.503 ± 25.357 | 137.548 | <0.001 |
LF | 58.584 ± 3.452 | 38.821 ± 1.773 | 48.703 ± 19.867 | 121.672 | <0.001 |
平均值 | 67.169 ± 15.372 | 40.037 ± 5.141 | 53.603 ± 22.683 | 142.5311) | <0.0011) |
F值/t值 | 119.436 | 6.973 | 133.6531) | F = 157.9132) | |
P值 | < 0.001 | 0.205 | < 0.0011) | P < 0.0012) |
Table 1 Changes in the blood glucose levels of the rats in the four groups $\bar{x}$ ± s, mmol/L
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 75.753 ± 5.382 | 41.253 ± 2.902 | 58.503 ± 25.357 | 137.548 | <0.001 |
LF | 58.584 ± 3.452 | 38.821 ± 1.773 | 48.703 ± 19.867 | 121.672 | <0.001 |
平均值 | 67.169 ± 15.372 | 40.037 ± 5.141 | 53.603 ± 22.683 | 142.5311) | <0.0011) |
F值/t值 | 119.436 | 6.973 | 133.6531) | F = 157.9132) | |
P值 | < 0.001 | 0.205 | < 0.0011) | P < 0.0012) |
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 38.583 ± 0.856 | 30.052 ± 0.623 | 34.223 ± 5.040 | 11.538 | 0.001 |
LF | 21.351 ± 0.652 | 20.823 ± 0.774 | 21.231 ± 0.395 | 0.654 | 0.549 |
平均值 | 29.968 ± 9.950 | 25.485 ± 5.070 | 27.727 ± 7.694 | 126.7361) | <0.0011) |
F值/t值 | 116.215 | 23.654 | 93.7671) | F = 132.9092) | |
P值 | <0.001 | 0.001 | <0.0011) | P < 0.0012) |
Table 2 Changes in the insulin levels of the rats in the four groups $\bar{x}$ ± s, μg/L
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 38.583 ± 0.856 | 30.052 ± 0.623 | 34.223 ± 5.040 | 11.538 | 0.001 |
LF | 21.351 ± 0.652 | 20.823 ± 0.774 | 21.231 ± 0.395 | 0.654 | 0.549 |
平均值 | 29.968 ± 9.950 | 25.485 ± 5.070 | 27.727 ± 7.694 | 126.7361) | <0.0011) |
F值/t值 | 116.215 | 23.654 | 93.7671) | F = 132.9092) | |
P值 | <0.001 | 0.001 | <0.0011) | P < 0.0012) |
大鼠 | P | C | 平均值 | F/t值 | P值 |
---|---|---|---|---|---|
HF | 5.902 ± 0.313 | 4.852 ± 0.231 | 5.376 ± 0.605 | 5.156 | 0.030 |
LF | 3.234 ± 0.153 | 3.241 ± 0.184 | 3.240 ± 0.006 | 0.523 | 0.875 |
平均值 | 4.569 ± 1.537 | 4.047 ± 0.930 | 4.308 ± 1.209 | 16.2151) | 0.0071) |
F值/t值 | 53.245 | 13.854 | 63.3621) | F = 33.5522) | |
P值 | 0.001 | 0.007 | 0.0011) | P = 0.0032) |
Table 3 Changes in the insulin resistance index of the rats in the four groups $\bar{x}$ ± s
大鼠 | P | C | 平均值 | F/t值 | P值 |
---|---|---|---|---|---|
HF | 5.902 ± 0.313 | 4.852 ± 0.231 | 5.376 ± 0.605 | 5.156 | 0.030 |
LF | 3.234 ± 0.153 | 3.241 ± 0.184 | 3.240 ± 0.006 | 0.523 | 0.875 |
平均值 | 4.569 ± 1.537 | 4.047 ± 0.930 | 4.308 ± 1.209 | 16.2151) | 0.0071) |
F值/t值 | 53.245 | 13.854 | 63.3621) | F = 33.5522) | |
P值 | 0.001 | 0.007 | 0.0011) | P = 0.0032) |
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 88.203 ± 6.821 | 40.122 ± 3.254 | 64.163 ± 39.651 | 174.548 | <0.001 |
LF | 61.614 ± 5.352 | 39.452 ± 5.103 | 50.533 ± 22.458 | 164.243 | <0.001 |
平均值 | 74.909 ± 16.672 | 39.787 ± 6.341 | 57.348 ± 35.784 | 171.4321) | <0.0011) |
F值/t值 | 154.452 | 3.753 | 87.7241) | F = 132.6092) | |
P值 | <0.001 | 0.763 | < 0.0011) | P<0.0012) |
Table 4 Changes in TNF-α expression in the rats in the four groups $\bar{x}$ ± s, μg/L
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 88.203 ± 6.821 | 40.122 ± 3.254 | 64.163 ± 39.651 | 174.548 | <0.001 |
LF | 61.614 ± 5.352 | 39.452 ± 5.103 | 50.533 ± 22.458 | 164.243 | <0.001 |
平均值 | 74.909 ± 16.672 | 39.787 ± 6.341 | 57.348 ± 35.784 | 171.4321) | <0.0011) |
F值/t值 | 154.452 | 3.753 | 87.7241) | F = 132.6092) | |
P值 | <0.001 | 0.763 | < 0.0011) | P<0.0012) |
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 28.553 ± 0.512 | 20.125 ± 0.255 | 24.343 ± 4.890 | 3.301 | 0.033 |
LF | 4.256 ± 0.435 | 4.655 ± 0.147 | 4.457 ± 0.443 | 0.468 | 0.361 |
平均值 | 16.412 ± 14.046 | 12.377 ± 8.931 | 14.396 ± 11.108 | 15.2111) | < 0.0011) |
F值/t值 | 131.705 | 153.691 | 122.4981) | F = 148.0592) | |
P值 | <0.001 | <0.001 | <0.0011) | P<0.0012) |
Table 5 Changes in IL-6 expression in the rats in the four groups $\bar{x}$ ± s, μg/L
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 28.553 ± 0.512 | 20.125 ± 0.255 | 24.343 ± 4.890 | 3.301 | 0.033 |
LF | 4.256 ± 0.435 | 4.655 ± 0.147 | 4.457 ± 0.443 | 0.468 | 0.361 |
平均值 | 16.412 ± 14.046 | 12.377 ± 8.931 | 14.396 ± 11.108 | 15.2111) | < 0.0011) |
F值/t值 | 131.705 | 153.691 | 122.4981) | F = 148.0592) | |
P值 | <0.001 | <0.001 | <0.0011) | P<0.0012) |
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 18.632 ± 3.453 | 8.453 ± 2.094 | 13.543 ± 11.564 | 42.823 | <0.001 |
LF | 8.231 ± 3.153 | 6.243 ± 2.181 | 7.237 ± 4.873 | 3.421 | 0.187 |
平均值 | 13.432 ± 9.376 | 7.348 ± 2.368 | 10.390 ± 8.657 | 36.4321) | <0.0011) |
F值/t值 | 34.572 | 3.784 | 47.8651) | F = 28.2152) | |
P值 | < 0.001 | 0.156 | < 0.0011) | P < 0.0012) |
Table 6 Changes in leptin expression in the rats in the four groups $\bar{x}$ ± s, μg/L
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 18.632 ± 3.453 | 8.453 ± 2.094 | 13.543 ± 11.564 | 42.823 | <0.001 |
LF | 8.231 ± 3.153 | 6.243 ± 2.181 | 7.237 ± 4.873 | 3.421 | 0.187 |
平均值 | 13.432 ± 9.376 | 7.348 ± 2.368 | 10.390 ± 8.657 | 36.4321) | <0.0011) |
F值/t值 | 34.572 | 3.784 | 47.8651) | F = 28.2152) | |
P值 | < 0.001 | 0.156 | < 0.0011) | P < 0.0012) |
Figure 2 CD31-RAGE double-positive endothelial cell infiltration as determined by double immunofluorescence staining in the 4 groups using laser scanning confocal microscopy bar = 50 μm.
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 165.702 ± 15.304 | 102.853 ± 10.007 | 134.080 ± 37.348 | 153.654 | 0.027 |
LF | 53.352 ± 5.441 | 40.604 ± 5.771 | 46.890 ± 7.434 | 25.869 | 0.415 |
平均值 | 109.456 ± 64.887 | 71.459 ± 36.643 | 90.485 ± 52.854 | 529.0361) | P<0.0011) |
F值/t值 | 431.551 | 116.651 | 467.6701) | F = 649.6122) | |
P值 | 0.001 | 0.040 | 0.0011) | P < 0.0012) |
大鼠 | P | C | 平均值 | F值/t值 | P值 |
---|---|---|---|---|---|
HF | 165.702 ± 15.304 | 102.853 ± 10.007 | 134.080 ± 37.348 | 153.654 | 0.027 |
LF | 53.352 ± 5.441 | 40.604 ± 5.771 | 46.890 ± 7.434 | 25.869 | 0.415 |
平均值 | 109.456 ± 64.887 | 71.459 ± 36.643 | 90.485 ± 52.854 | 529.0361) | P<0.0011) |
F值/t值 | 431.551 | 116.651 | 467.6701) | F = 649.6122) | |
P值 | 0.001 | 0.040 | 0.0011) | P < 0.0012) |
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