Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (9): 598-601.doi: 10.12016/j.issn.2096-1456.2019.09.010

• Review Articles • Previous Articles     Next Articles

Research progress of probiotics in the prevention and treatment of oral infectious diseases

LI Jiatong1,ZHOU Xuedong1,XU Xin1,WANG Yan2()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Deparment of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-09-09 Revised:2019-04-26 Online:2019-09-20 Published:2019-09-20
  • Contact: Yan WANG E-mail:1522965266@qq.com

RichHTML

15

PDF (PC)

60

Abstract:

Oral infectious diseases include caries, periodontal disease, halitosis, candidiasis albicans and so on. Over the past few decades, probiotics have mainly been studied in the field of the gastrointestinal tract. In recent years, probiotics have begun to be used in the prevention and treatment of various oral diseases and have become a new field in the research of oral disease prevention and control technology. This paper reviews the research progress of probiotics applied in the prevention and treatment of various oral infectious diseases. A review of the literature shows that probiotics can prevent and cure dental caries by inhibiting the growth of Streptococcus mutans and competing with them for nutrition and attachment sites. Probiotics not only inhibit periodontal pathogens and reduce the production of sulfide, they also regulate the body’s immune function to alleviate halitosis and periodontal inflammation. Probiotics can inhibit periodontal caries by inhibiting them. Probiotics can inhibit them mycelial growth of Candida albicans and interfere with its adherence, thus playing a role in the prevention and treatment of oral candidiasis. Current studies have shown that probiotics play an auxiliary role in the treatment of caries, periodontitis, halitosis and oral candidiasis. However, the mechanism of probiotics in the prevention and treatment of oral infectious diseases is still unclear, and the safety of probiotics remains to be further studied. In the future, oral probiotics should be studied with reference to intestinal probiotics to better work to prevent and treat oral diseases.

Key words: probiotics, lactobacillus, oral infectious disease, oral microbial ecology, dental caries, periodontitis, halitosis, oral candidiasis

CLC Number: 

  • R78

Table 1

Common oral probiotics"

乳杆菌属 双歧杆菌属 其它
嗜酸乳杆菌
干酪乳杆菌
卷曲乳杆菌
保加利亚乳杆菌
发酵乳杆菌
加氏乳杆菌		 两岐双歧杆菌
短双歧杆菌
婴儿双歧杆菌
长双歧杆菌
链状双歧杆菌
 布拉酵母菌
乳酸乳球菌乳脂亚种
粪肠球菌
唾液链球菌嗜热亚种
中间链球菌
[1] Meurman JH, Stamatova IV . Probiotics: evidence of oral health implications[J]. Folia Med (Plovdiv), 2018,60(1):21-29.
[2] Olson JK, Navarro J, Allen J , et al. An enhanced lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis[J]. Am J Physiol Gastrointest Liver Physiol, 2018,315(3):408-419.
[3] Pereira Leao MV, Aureliano Tavares TA , Ferreira Dos Santos SS, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis[J]. Clin Oral Investig, 2018,22(7):2511-2518.
[4] 周学东, 施文元 . 口腔微生态学[M] . 北京: 人民卫生出版社, 2013: 10-13.
[5] Vos T, Abajobir AA, Abate KH , et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet, 2017: 1211-1259.
[6] 王兴 . 第四次全国口腔健康流行病学调查报告[M]. 北京: 人民卫生出版社, 2018: 39.
[7] Rossoni RD, Velloso MD, De Barros PP , et al. Inhibitory effect of probiotic Lactobacillus supernatants from the oral cavity on Streptococcus mutans biofilms[J]. Microb Pathog, 2018,123(10):361-367.
[8] Pahumunto N, Piwat S, Chankanka O , et al. Reducing mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children: a randomized placebo-controlled trial[J]. Acta Odontol Scand, 2018,76(5):331-337.
[9] Villavicencio J, Villegas LM, Arango MC , et al. Effects of a food enriched with probiotics on Streptococcus mutans and Lactobacillus spp. salivary counts in preschool children: a cluster randomized trial[J]. J Appl Oral Sci, 2018,69:389-394.
[10] Krzy$\acute{s}$ciak W, Ko$\acute{s}$cielniak D, Papie$\dot{z}$ M , et al. Effect of a lactobacillus salivarius probiotic on a double-species streptococcus mutans and candida albicans caries biofilm[J]. Nutrients, 2017,9(11):11-14.
[11] Rosier BT, Marsh PD, Mira A . Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis[J]. J Dent Res, 2018,97(4):371-380.
[12] Mahasneh SA, Mahasneh AM . Probiotics: a promising role in dental health[J]. Dent J (Basel), 2017,5(4):26.
[13] Schwendicke F, Doerfer C, Kneist S , et al. Cariogenic effects of probiotic lactobacillus rhamnosus GG in a dental biofilm model[J]. Caries Res, 2014,48(3):186-192.
[14] Nordendahl E, Gustafsson A, Norhammar A , et al. Severe periodontitis is associated with myocardial infarction in females[J]. J Dent Res, 2018,97(10):1114-1121.
[15] Yu YH, Doucette-Stamm L, Rogus J , et al. Family history of MI, smoking, and risk of periodontal disease[J]. J Dent Res, 2018,97(10):1106-1113.
[16] Hashimoto H, Hashimoto S, Muto A , et al. Influence of plaque control on the relationship between rheumatoid arthritis and periodontal health status among Japanese rheumatoid arthritis patients[J]. J Periodontol, 2018,89(9):1033-1042.
[17] Becirovic A, Abdi-Dezfuli JF, Hansen MF , et al. The effects of a probiotic milk drink on bacterial composition in the supra-and subgingival biofilm: a pilot study[J]. Benef Microbes, 2018,9(6):865-874.
[18] Gatej SM, Marino V, Bright R , et al. Probiotic lactobacillus rhamnosus GG prevents alveolar bone loss in a mouse model of experimental periodontitis[J]. J Clin Periodontol, 2018,45(2):204-212.
[19] Invernici MM, Salvador SL, Silva PH , et al. Effects of bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial[J]. J Clin Periodontol, 2018,45(10):1198-1210.
[20] Morales A, Gandolfo A, Bravo J , et al. Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo-controlled trial with 9-month follow-up[J]. J Appl Oral Sci, 2018,26:e20170075.
[21] Hallstrom H, Lindgren S, Yucel-Lindberg TA , et al. Effect of probiotic lozenges on inflammatory reactions and oral biofilm during experimental gingivitis[J]. Acta Odontol Scand, 2013,71(3/4):828-833.
[22] Liu TH, Tsai TY, Pan TM . The Anti-Periodontitis effects of ethanol extract prepared using lactobacillus paracasei subsp paracasei NTU 101[J]. Nutr, 2018,10(4):472-474.
[23] Maekawa T, Hajishengallis G . Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss[J]. J Periodontal Res, 2014,49(6):785-791.
[24] Georgiou AC, Laine ML, Deng DM , et al. Efficacy of probiotics: clinical and microbial parameters of halitosis[J]. J Breath Res, 2018,12(4):046010.
[25] Brignardello-Petersen R . Probiotics seem to decrease organoleptic scores in patients with halitosis, but there is uncertainty about their effect on volatile sulfur compounds[J]. J Am Dent Assoc, 2018,149(5):e79.
[26] Ji YO, Shin IS, Jeon JG , et al. The effect of probiotics on halitosis: a systematic review and meta-analysis[J]. Probiotics Antimicrob Proteins, 2017,11(1):150-157.
[27] Penala S, Kalakonda B, Pathakota KR , et al. Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: a randomized controlled trial[J]. J Res Pharm Pract, 2016,5(2):86-93.
[28] Shin HS, Baek DH, Lee SH . Inhibitory effect of Lactococcus lactis on the bioactivity of periodontopathogens[J]. J Gen Appl Microbiol, 2018,64(2):55-61.
[29] De Barros PP, Scorzoni L, Ribeiro FC , et al. Lactobacillus paracasei 28.4 reduces in vitro hyphae formation of Candida albicans and prevents the filamentation in an experimental model of Caenorhabditis elegans[J]. Microb Pathog, 2018,117:80-87.
[30] Miyazima TY, Ishikawa KH, Mayer M , et al. Cheese supplemented with probiotics reduced the Candida levels in denture wearers-RCT[J]. Oral Dis, 2017,23(7):919-925.
[31] Sutula J, Coulthwaite L, Thomas L , et al. The effect of a commercial probiotic drink on oral microbiota in healthy complete denture wearers[J]. 2012,23:18404 .
[32] Mailäender-Sánchez D, Braunsdorf C, Grumaz C , et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion[J]. PLoS One, 2017,12(10):e0184438.
[33] Rossoni RD, De Barros PP, De Alvarenga JA , et al. Antifungal activity of clinical Lactobacillus strains against Candida albicans biofilms: identification of potential probiotic candidates to prevent oral candidiasis[J]. Biofouling, 2018,34(2):212-225.
[34] Di Pierro F, Risso P, Poggi EF , et al. Use of streptococcus salivarius K12 to reduce the incidence of pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects[J]. Minerva Pediatr, 2018,70(3):240-245.
[35] Esaiassen E, Hjerde E, Cavanagh JP , et al. Bifidobacterium bacteremia: clinical characteristics and a genomic approach to assess pathogenicity[J]. J Clin Microbiol, 2017,55(7):2234-2248.
[36] Koyama S, Fujita H, Shimosato T , et al. Septicemia from Lactobacillus rhamnosus GG, from a probiotic enriched yogurt, in a patient with autologous stem cell transplantation[J]. Probiotics Antimicrob Proteins, 2019,11(1):295-298.
[1] HUANG Shaohong,WU Linmei. The prevalence of dental caries in urban areas is lower than that in rural areas--analysis of changes in the epidemiological characteristics of caries in urban and rural areas [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(5): 273-278.
[2] HE Yuanli,REN Biao,CHEN Xuan,ZOU Ling. Mechanism research of srtA gene on the oxidation tolerance of Streptococcus mutans [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(5): 292-297.
[3] WU Hongyu,MA Xiaoxin,LU Haixia,FENG Xiping,GU Qin,YE Wei,XIE Yingxin,XIE Danshu,WANG Wenji. Investigation of dental caries and periodontal conditions in maintenance hemodialysis patients [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(5): 313-317.
[4] ZHANG Limu,LIN Xiaoping. Research progress on the mechanism of C-reactive protein mediated periodontitis and systemic diseases [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 184-188.
[5] LIU Haotian,LI Huihui,LIU Shanshan. Research progress on the relationship between enamel-related gene polymorphisms and caries susceptibility [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(2): 123-126.
[6] FU Zhuohui,DENG Jiaxin,CHEN Yuan,WANG Yan. Research progress into probiotics for the prevention of dental caries [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(9): 603-608.
[7] Gang WANG,Peng SUN,Juan LI,Shiguang HUANG. Expression of the receptor of advanced glycation end products in gingival tissue endothelial cells from type 2 diabetic rats with chronic periodontitis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(7): 428-434.
[8] DAI Qian,YU Yuanling,HUANG Shiguang. Macrophage IL-33 expression in macrophages of human chronic periapical periodontitis and apical cyst [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(5): 300-303.
[9] YANG Ting,ZHANG Wanting,LI Beibei,DONG Ying,CAO Hongfei,ZHAO Jin. Distribution of oral Streptococcus mutans and its correlation with dental caries in children of Bortala Mongolian Autonomous Prefecture [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(4): 219-225.
[10] GUO Xiao,DU Xinmei,CHENG Lei,ZHOU Xuedong,LI Mingyun. Research progress on the function and metabolism of d-alanine in bacteria [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(4): 264-267.
[11] XU Xiongcheng,ZHONG Quan,LUO Kai. Application of 3D printing technology in preparation of scaffolds for periodontal tissue regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(3): 189-193.
[12] ZHU Yanxia,Gegen tana. Research progress of IL-33/ST2 signaling pathway in bone metabolism [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(3): 202-204.
[13] ZHANG Fan,REN Weiwei,GUAN Qin,ZHAO Hui,LI Shouhong. The management of dental fear symptoms in children in a coparticipation model [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(2): 104-106.
[14] WANG Ye,LIN Xiaoping. Research progress on the common risk factors and related mechanisms of periodontitis and osteoporosis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(12): 794-798.
[15] WANG Min, GE Song. Research progress on the T cell receptor CDR3 spectral sequence of periodontitis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(12): 799-803.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Hong-chang LAI,Jun-yu SHI. Maxillary sinus floor elevation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(1): 8 -12 .
[2] Pin ZHOU, Yang-fei LI. MRI study of temporomandibular joint disc position in asymptomatic volunteers[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(4): 239 -244 .
[3] Xinxin XIA, Fang FANG, Lijuan CHENG. Shaping ability of Pathfile and WaveOne in simulated root canals[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(6): 365 -368 .
[4] Yuanhong LI, Xinyi FANG, Yu QIU, Lei CHENG. Experimental study on the effects of green tea on salivary flow rate and pH value[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(9): 560 -564 .
[5] Chengzhang LI. Masticatory muscles in occlusion[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(12): 755 -760 .
[6] . [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(1): 1 .
[7] Zhirong WU, Shiguang Huang. Research progress on the etiology, clinical examination and treatment of peri-implantitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(6): 401 -405 .
[8] Xiaowu YAO, Shisheng CHEN, Zizheng LU, Minxiao LIN. Clinical report and literature review on the amyloidosis of salivary glands[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 533 -536 .
[9] Lan LIAO, Lijun ZENG. Updated research on digitalization in aesthetic restoration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 409 -414 .
[10] Yu LU, Chengxia LIU, Zhongjun LIU. Role of TRAF6 in inflammatory responses of human osteoblast-like cells with Enterococcusfaecalis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(7): 420 -425 .

Copyright © Editorial Board of Journal of Prevention and Treatment for Stomatological Diseases

This work is licensed under a Creative Commons Attribution 3.0 License.

Address:Guangzhou City Jiangnan Road South 366, Editorial office ofJournal of Prevention and Treatment for Stomatological Diseases, zip code: 510280　Fax:020-34304115　E-mail：kqjbfz@vip.126.com

Supported by:Beijing Magtech

This work is licensed under a Creative Commons Attribution 3.0 License.