Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (9): 598-601.DOI: 10.12016/j.issn.2096-1456.2019.09.010

• Review Articles • Previous Articles     Next Articles

Research progress of probiotics in the prevention and treatment of oral infectious diseases

LI Jiatong1,ZHOU Xuedong1,XU Xin1,WANG Yan2()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Deparment of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-09-09 Revised:2019-04-26 Online:2019-09-20 Published:2019-09-20
  • Contact: Yan WANG

益生菌防治口腔感染性疾病的研究进展

李佳桐1,周学东1,徐欣1,王艳2()   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科,四川 成都 (610041)
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院儿童口腔科,四川 成都 (610041)
  • 通讯作者: 王艳
  • 作者简介:李佳桐,医师,硕士研究生在读,Email: 1522965266@qq.com
  • 基金资助:
    国家自然科学基金项目(81771099);国家自然科学基金项目(81600864);四川省科技计划项目(2016JY0006);口腔疾病研究国家重点实验室四川大学自主研究课题(SKLOD201705);四川大学华西口腔医院青年科学研究基金(2015-11)

Abstract:

Oral infectious diseases include caries, periodontal disease, halitosis, candidiasis albicans and so on. Over the past few decades, probiotics have mainly been studied in the field of the gastrointestinal tract. In recent years, probiotics have begun to be used in the prevention and treatment of various oral diseases and have become a new field in the research of oral disease prevention and control technology. This paper reviews the research progress of probiotics applied in the prevention and treatment of various oral infectious diseases. A review of the literature shows that probiotics can prevent and cure dental caries by inhibiting the growth of Streptococcus mutans and competing with them for nutrition and attachment sites. Probiotics not only inhibit periodontal pathogens and reduce the production of sulfide, they also regulate the body’s immune function to alleviate halitosis and periodontal inflammation. Probiotics can inhibit periodontal caries by inhibiting them. Probiotics can inhibit them mycelial growth of Candida albicans and interfere with its adherence, thus playing a role in the prevention and treatment of oral candidiasis. Current studies have shown that probiotics play an auxiliary role in the treatment of caries, periodontitis, halitosis and oral candidiasis. However, the mechanism of probiotics in the prevention and treatment of oral infectious diseases is still unclear, and the safety of probiotics remains to be further studied. In the future, oral probiotics should be studied with reference to intestinal probiotics to better work to prevent and treat oral diseases.

Key words: probiotics, lactobacillus, oral infectious disease, oral microbial ecology, dental caries, periodontitis, halitosis, oral candidiasis

摘要:

口腔感染性疾病常见有龋病、牙周病、白色念珠菌病等。过去几十年,益生菌的研究主要集中在胃肠道领域。近年来,益生菌开始应用于各种口腔疾病的防治,成为口腔疾病防治技术研究的新兴领域,本文对益生菌应用于各类口腔感染性疾病防治的研究进展进行综述。文献复习结果表明,益生菌可通过抑制变异链球菌生长及与其竞争营养和附着位点达到防治龋病的目的;益生菌不仅可以抑制牙周致病菌,减少硫化物的产生,还可调节机体免疫功能从而减轻口臭及牙周炎症;益生菌可通过抑制白色念珠菌的菌丝生长并干扰其黏附,在口腔念珠菌病的防治中发挥作用。目前研究显示益生菌对龋病、牙周病、口臭及口腔念珠菌病有一定的辅助作用,但益生菌在防治口腔感染性疾病过程中的作用机制尚不明确,安全性也有待进一步研究,今后可参考肠道益生菌的研究进行口腔益生菌的研究,使益生菌更好地服务于口腔疾病的防治中。

关键词: 益生菌, 乳酸杆菌, 口腔感染性疾病, 口腔微生态, 龋病, 牙周病, 口臭, 口腔念珠菌病

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