Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (9): 598-601.doi: 10.12016/j.issn.2096-1456.2019.09.010

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Research progress of probiotics in the prevention and treatment of oral infectious diseases

LI Jiatong1,ZHOU Xuedong1,XU Xin1,WANG Yan2()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Deparment of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-09-09 Revised:2019-04-26 Online:2019-09-20 Published:2019-09-20
  • Contact: Yan WANG E-mail:1522965266@qq.com

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Abstract:

Oral infectious diseases include caries, periodontal disease, halitosis, candidiasis albicans and so on. Over the past few decades, probiotics have mainly been studied in the field of the gastrointestinal tract. In recent years, probiotics have begun to be used in the prevention and treatment of various oral diseases and have become a new field in the research of oral disease prevention and control technology. This paper reviews the research progress of probiotics applied in the prevention and treatment of various oral infectious diseases. A review of the literature shows that probiotics can prevent and cure dental caries by inhibiting the growth of Streptococcus mutans and competing with them for nutrition and attachment sites. Probiotics not only inhibit periodontal pathogens and reduce the production of sulfide, they also regulate the body’s immune function to alleviate halitosis and periodontal inflammation. Probiotics can inhibit periodontal caries by inhibiting them. Probiotics can inhibit them mycelial growth of Candida albicans and interfere with its adherence, thus playing a role in the prevention and treatment of oral candidiasis. Current studies have shown that probiotics play an auxiliary role in the treatment of caries, periodontitis, halitosis and oral candidiasis. However, the mechanism of probiotics in the prevention and treatment of oral infectious diseases is still unclear, and the safety of probiotics remains to be further studied. In the future, oral probiotics should be studied with reference to intestinal probiotics to better work to prevent and treat oral diseases.

Key words: probiotics, lactobacillus, oral infectious disease, oral microbial ecology, dental caries, periodontitis, halitosis, oral candidiasis

CLC Number: 

  • R78

Table 1

Common oral probiotics"

乳杆菌属 双歧杆菌属 其它
嗜酸乳杆菌
干酪乳杆菌
卷曲乳杆菌
保加利亚乳杆菌
发酵乳杆菌
加氏乳杆菌		 两岐双歧杆菌
短双歧杆菌
婴儿双歧杆菌
长双歧杆菌
链状双歧杆菌
 布拉酵母菌
乳酸乳球菌乳脂亚种
粪肠球菌
唾液链球菌嗜热亚种
中间链球菌
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