Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (9): 609-612.doi: 10.12016/j.issn.2096-1456.2019.09.012

• Review Articles • Previous Articles    

Research progress on the therapeutic effect of traditional Chinese medicine on fluorosis

SHI Chunling,LIU Yi()   

  1. Fengtian Dental Clinic, School of Stomatology, China Medical University, Shenyang 110013, China
  • Received:2018-07-14 Revised:2019-04-19 Online:2019-09-20 Published:2019-09-20
  • Contact: Yi LIU E-mail:liuyi256@126.com

Abstract:

Fluoride is an important trace element in the human body and has active chemical properties, but its safety range is narrow. Excessive intake of fluoride can easily lead to fluorosis and various metabolic disorders, mainly manifested as dental fluorosis and skeletal fluorosis. In recent years, an increasing number of scholars have studied traditional Chinese medicine (TCM) because of its long history, few side effects, convenient oral administration and abundant resources. This paper reviews the current research. The results of the literature review show that traditional Chinese medicine, such as asparagus, cistanche deserticola and quercetin, can effectively prevent and treat fluorosis diseases that affected soft and hard tissues of the body due to is antioxidant properties. Moreover, the protective effect of TCM on fluoride-excreting organs of the body can further restore the fluoride-excreting ability of the body and reduce the damage caused by excessive fluoride on tissues as well as reduce fluoride in tissues by combining with excessive fluoride in the body. TCM can effectively improve the pain and joint dysfunction caused by skeletal fluorosis. Traditional Chinese medicine has important value in the prevention and treatment of fluorosis by enhancing immunity, promoting metabolism, eliminating fluoride in vivo, and improving the self-regulation mechanism to prevent fluoride toxic damage in the body.

Key words: fluorosis, dental fluorosis, skeletal fluorosis, traditional Chinese medicine, curcumin, quercetin, epimedium, oxidative stress

CLC Number: 

  • R78
[1] 刘永林, 马培, 雒昆利 , 等. 1991-2012年中国地方性氟中毒病情动态变化[J]. 重庆师范大学学报(自然科学版), 2016,33(2):142-151.
[2] 张建明, 李剑波, 范卫华 , 等. 广东省12岁人群氟牙症抽样调查报告(2015-2016年)[J]. 口腔疾病防治, 2018,26(4):218-221.
[3] Gitte SV, Sabat R, Kamble K . Epidemiological survey of fluorosis in a village of Bastar division of Chhattisgarh state, India[J]. Int J Med Public Health, 2015,5(3):232.
[4] 任建萍 . 中药疗法在中度氟骨症患者肢体关节功能中的改善效果观察[J]. 中国地方病防治杂志, 2018,33(2):156-158.
[5] Hamza RZ, El-Shenawy NS, Ismail HA . Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat[J]. J Basic Clin Physiol Pha, 2015,26(3):237-251.
[6] Zhao L, Li J, Su J , et al. LS8 cell apoptosis induced by NaF through p-ERK and p-JNK--a mechanism study of dental fluorosis[J]. Acta Odontol Scand, 2016,74(7):539-549.
[7] Bronckers AL, Donacian ML . Magnesium, pH regulation and modulation by mouse ameloblasts exposed to fluoride[J]. Bone, 2017,94:56-64.
[8] Lakhani N, Vandana LK . Microhardness of nonfluorosed and fluorosed dental cementum: an in vitro study[J]. SRM J Res Dent Sci, 2017,8(2):74-77.
[9] Mousny M, Omelon S, Wise L , et al. Fluoride effects on bone formation and mineralization are influenced by genetics[J]. Bone, 2008,43(6):1067-1074.
[10] Everett ET . Fluoride’s effects on the formation of teeth and bones, and the influence of genetics[J]. J Dent Res, 2011,90(5):552-560.
[11] Kheradpisheh Z, Mirzaei M, Mahvi AH , et al. Impact of drinking water fluoride on human thyroid hormones: a case-control study[J]. Sci Rep, 2018,8(1):2674.
[12] Sarkar C, Pal S . Ameliorative effect of resveratrol against fluoride-induced alteration of thyroid function in male wistar rats[J]. Biol Trace Elem Res, 2014,162(1/3):278-287.
[13] Abbas M, Siddiqi MH, Khan KA , et al. Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus[J]. Toxicol Rep, 2017,4:450-454.
[14] 颉晓玲, 胡兰文, 张晓薇 , 等. 氟中毒患者机体T细胞亚群及Th1/Th2细胞因子的分析[J]. 现代检验医学杂志, 2012,27(6):83-85.
[15] 秦俊法, 陈磐华 . 中国的中药微量元素研究Ⅰ. 微量元素: 一切中药的基本成分[J]. 广东微量元素科学, 2010,17(11):1-18.
[16] 王小平, 李立红 . 抗氟中毒方剂中微量元素含量分析[J]. 微量元素与健康研究, 2001,18(4):43-44.
[17] 孙秀娟, 于燕妮, 肖宇明 . 丹蓝仙硼疗氟胶囊对氟中毒大鼠骨保护蛋白配体和巨噬细胞集落刺激因子基因及其蛋白表达水平的影响[J]. 中华病理学杂志, 2010,39(10):695-700.
[18] Inkielewicz-Stepniak I, Radomski MW, Wozniak M . Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells[J]. Food Chem Toxicol, 2012,50(3/4):583-589.
[19] 白兴卫 . 苁蓉片用于地方性氟中毒治疗临床观察[J]. 内蒙古中医药, 2013,32(21):24-25.
[20] Hamza RZ. El-Shenawy NS, Ismail HA . Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat[J]. J Basic Clin Physiol Pha, 2015,26(3):237-251.
[21] Nageshwar M, Sudhakar K, Reddy N , et al. Neuroprotective effects of curcumin on sodium fluoride induced behavioral and enzymatic changes in brain and muscles of rat[J]. J Environ Biol, 2017,38:675-681.
[22] Adedara IA, Abolaji AO, Idris UF , et al. Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats[J]. Chem Biol Interact, 2016,261(1):1-10.
[23] Balaji B, Kumar EP, Kumar A . Evaluation of standardized Bacopa monniera extract in sodium fluoride-induced behavioral, biochemical, and histopathological alterations in mice[J]. Toxicol Ind Health, 2015,31(1):18-30.
[24] Miltonprabu S, Thangapandiyan S . Epigallocatechin gallate potentially attenuates fluoride induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats[J]. J Trace Elem Med Biol, 2015,29:321-335.
[25] 王飞清, 李艳菊, 王宁 , 等. 天门冬对氟中毒大鼠机体氧化应激的影响[J]. 时珍国医国药, 2017,28(8):1862-1863.
[26] Yadav N, Sharma S, Kp S , et al. Protective role of diet supplements Spirulina and Tamarind fruit pulp on kidney in sodium fluoride exposed swiss albino mice: histological and biochemical indices[J]. Indian J Exp Biol, 2016,54(1):44.
[27] 郭生琼, 喻茂娟, 申惠鹏 , 等. 复方中药对慢性氟中毒大鼠氟骨症的骨形态计量学影响[J]. 现代预防医学, 2016,43(8):1471-1475.
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