Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (10): 638-641.doi: 10.12016/j.issn.2096-1456.2019.10.005

• Cinical Study • Previous Articles     Next Articles

Clinical study of the treatment effects of direct current iontophoresis of triamcinolone acetonide on oral submucous fibrosis

PENG Haiyan1,JIANG Xiaowen1,2(),FU Zhimin2,HUANG Huaqin1,CHEN Jinyong1   

  1. 1. The department of stomatology, the First Peoples’ hospital of Chenzhou City, the South Medical University, Chenzhou 423000, China;
    2. Institute of translation madicine, University of China South, Chenzhou 423000, China
  • Received:2019-05-18 Revised:2019-08-25 Online:2019-10-20 Published:2019-10-20
  • Contact: Xiaowen JIANG E-mail:jxw0927@163.com

Abstract:

Objective To observe the clinical effects of direct current iontophoresis (DCI) of triamcinolone acetonide (TA) on treatment of oral submucous fibrosis. Methods Fifty-one patients were randomly divided in group A (n=25), which underwent local submucous injection with TA (20 mg for each side) once a week for 8 weeks, and group B (n=26), which underwent local TA administration by DCI (20 mg for each side) for 8 weeks, follow-up was performed 12 weeks after treatment. The distances between the upper and lower central incisors were recorded. The visual analogue scale (VAS) was used to evaluate the pain caused by the two treatments. The Oral Health Impact Profile (OHIP)-14 was used to assess the entire effect of treatments. Results At 8 weeks of treatment, the mouth opening was increased by 3.25 ± 0.77 mm in group A and 3.76 ± 0.88 mm in group B (P< 0.05). At 20 weeks after treatment, the mouth opening was increased by 2.61 ± 0.62 mm in group A and 2.53 ± 0.52 mm in group B (P > 0.05). After the first treatment, the VAS score of group A was 7.88 ± 0.80, and the VAS score of group B was 2.47 ± 0.64, resulting in a statistically significant difference (P< 0.001). After the last treatment, the VAS score was 7.29 ± 0.53 in group A and 1.77 ± 0.48 in group B, resulting in a statistically significant difference (P< 0.001). The VAS scores of the two groups were decreased after treatment, and the difference between groups was statistically significant (P< 0.001). The OHIP-14 score of patients in group A before treatment was 31.44 ± 2.55, while that in group B was 32.04 ± 2.20 (P > 0.05). At 20 weeks after treatment, the score in group A was 13.52 ± 3.31 and that in group was 12.04 ± 2.84 (P > 0.05). The OHIP-14 scores of the two groups were significantly decreased before and after treatment, and the difference between groups was statistically significant (P< 0.001). Conclusion The results suggest that local TA administration by DCI might be a promising method for treatment in the early and middle disease periods in OSF patients.

Key words: oral submucous fibrosis, triamcinolone acetonide, direct current iontophoresis, visual analogue scale, oral health impact profile

CLC Number: 

  • R781.5

Figure 1

The photographs of the patients in the two groups during treatment"

Table 1

The result of the increasing degree of mouth opening between two groups at 8 weeks of treatment and 12 weeks after treatment"

治疗前
开口度
治疗第8
周 开口度
治疗后12周开口度 治疗第8周
开口增加值
治疗后12周开口增加值
A组
B组
t
P
25.11 ± 1.73
26.05 ± 1.77
-1.935
0.059
28.36 ± 1.82
29.76 ± 1.91
-2.686
0.010
27.72 ± 1.75
28.54 ± 1.71
-1.678
0.100
3.25 ± 0.77
3.76 ± 0.88
-2.018
0.034
2.61 ± 0.62
2.53 ± 0.52
0.498
0.621
[1] Ray JG, Chatterjee R, Chaudhuri K . Oral submucous fibrosis: a global challenge. Rising incidence, risk factors, management, and research priorities[J]. Periodontol 2000, 2019,80(1):200-212.
[2] Peng Q, Li HY, Chen J , et al. Oral submucous fibrosis in Asian countries[J]. J Oral Pathol Med, 2019: 12924.
[3] 杨博, 符梦凡, 唐瞻贵 . 槟榔碱涂擦对颊黏膜活检术后SD大鼠生存的影响[J]. 口腔疾病防治, 2019,27(7):423-427.
[4] Choudhari SS, Kulkarni DG, Patankar S , et al. Angiogenesis and fibrogenesis in oral submucous fibrosis: a viewpoint[J]. J Contemp Dent Pract, 2018,2(19):242-245.
[5] Panta P, Sarode SC, Sarode GS , et al. New directions for oral submucous fibrosis research: whole evaluation for holistic rehabilitation[J]. J Contemp Dent Pract, 2018,19(8):901-903.
[6] Arakeri G, Rai KK, Boraks G , et al. Current protocols in the management of oral submucous fibrosis: an update[J]. J Oral Pathol Med, 2017,46(6):418-423.
[7] Tp B, Ag TG, Varghese M , et al. Evaluation of therapeutic efficacy of different treatment modalities in oral submucous fibrosis:a comparative study[J]. J Contemp Dent Pract, 2019,20(3):390-394.
[8] Arakeri G, Rai KK, Hunasgi S , et al. Oral submucous fibrosis: an update on current theories of pathogenesis[J]. J Oral Pathol Med, 2017,46(6):406-412.
[9] Biradar SB, Munde AD, Biradar BC , et al. Oral submucous fibrosis: a clinico-histopathological correlational study[J]. J Cancer Res Ther, 2018,14(3):597-603.
[10] 龚振东, 房付春, 刘丽燕 , 等. 半导体激光联合白芍总苷胶囊治疗糜烂型口腔扁平苔藓的临床效果[J]. 口腔疾病防治, 2018,26(11):38-42.
[11] Re K, Patel S, Gandhi J , et al. Clinical utility of hyperbaric oxygen therapy in dentistry[J]. Med Gas Res, 2019,9(2):93-100.
[12] Dani VB, Patel SH . The effectiveness of therapeutic ultrasound in patients with oral submucosal fibrosis[J]. Indian J Cancer, 2018,55(3):248-250.
[13] Cordery SF, Husbands SM, Bailey CP , et al. Simultaneous transdermal delivery of buprenorphine hydrochloride and naltrexone hydrochloride by iontophoresis[J]. Mol Pharm, 2019,16(6):2808-2816.
[14] Giri TK, Chakrabarty S, Ghosh B . Transdermal reverse iontophoresis: a novel technique for therapeutic drug monitoring[J]. J Control Release, 2017,246:30-38.
[15] 蔡鑫嘉, 黄俊辉, 姚志刚 , 等. 丹参联合曲安奈德局部注射治疗口腔黏膜下纤维性变的meta分析[J]. 口腔疾病防治, 2018,26(6):374-378.
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