Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (12): 804-808.doi: 10.12016/j.issn.2096-1456.2019.12.011

• Review Articles • Previous Articles     Next Articles

The role of vitamin D and its analogues in the treatment of oral mucosal diseases and periodontal diseases

WU Qian,WANG Jian,NIU Li,YANG Xue,TANG Xiaolin()   

  1. Department of Periodontics, School of Stomatology, China Medical University, Shenyang 110002 , China
  • Received:2018-09-23 Revised:2019-07-17 Online:2019-12-20 Published:2019-12-30
  • Contact: Xiaolin TANG E-mail:xltang@cmu.edu.cn

Abstract:

Vitamin D is an essential nutrient in the body. In recent years, increasing attention has been paid to its role in regulating immunity and anti-inflammatory effects. However, the application of vitamin D in vivo may produce some side effects, such as hypercalcemia and hypercalciuria. Some analogs of vitamin D obtained through molecular modification can reduce the side effects while retaining a similar regulatory action as that of vitamin D. The supplementation of vitamin D or the use of vitamin D analogs may contribute to the prevention and treatment of immune inflammatory diseases. This article reviews the role of vitamin D and its analogues in the prevention and treatment of oral mucosal diseases and periodontal diseases. The literature review results show that vitamin D and its analogues can protect the integrity of the oral mucosal barrier, prevent or delay the occurrence of oral lichen planus, and provide a reference value for the prevention and treatment of periodontitis.

Key words: vitamin D, analogues, calcium and phosphorus metabolism, vitamin D receptor, hypercalcemia, hypercalciuria, immunity, inflammation

CLC Number: 

  • R78
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