Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (2): 118-122.doi: 10.12016/j.issn.2096-1456.2020.02.011

• Review Articles • Previous Articles     Next Articles

Application of Indocyanine green in visual treatment of oral cancer

ZHANG Yu,JI Tong()   

  1. Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People′s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2018-12-08 Revised:2019-10-09 Online:2020-02-20 Published:2020-02-25
  • Contact: Tong JI E-mail:jitongjitong@foxmail.com

Abstract:

Indocyanine green (ICG) is a fluorescence indicator characterized by low trauma, a long effect time, low cytotoxicity, and high imaging resolution. It has been widely used in biomedical applications. However, ICG is not widely used in the treatment of oral cancer. This article reviews the application of ICG in the diagnosis and treatment of oral cancer. The results of a literature review showed that in the diagnosis and treatment of oral cancer, ICG mainly plays a role through the enhanced permeability and retention (EPR) effect of fluorescent substances and in coupling with various tumor-specific antibodies. For tumor visualization, ICG can focus on the primary tumor and lymph node metastasis by coupling the specific tumor antibodies and the EPR effect to guide the complete resection of the primary tumor and the determination of neck lymphadenectomy. In the reconstruction of the oral, head and neck regions, semi-quantitative measurement of ICG fluorescence intensity can be used to design a guide for a vascularized flap during the operation, for early detection of flap crisis after the operation, and to guide clinical flap exploration opportunities. In nonsurgical treatments of oral cancer, such as photothermal therapy and photodynamic therapy, ICG, as an important component of photosensitive nanomaterials, has attracted the attention of many scholars. ICG has good application prospects in the resection, reconstruction, visualization and nonsurgical treatment of oral cancer.

Key words: indocyanine green, oral cancer, tumor visualization, free vascularized flap, reconstruction, fluorography, photodynamic therapy, sequential combined treatment

CLC Number: 

  • R78
[1] Chen W, Zheng R, Baade PD , et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016,66(2):115-132.
[2] Yang J, Tao HS, Cai W , et al. Accuracy of actual resected liver volume in anatomical liver resections guided by 3-dimensional parenchymal staining using fusion indocyanine green fluorescence imaging[J]. J Surg Oncol, 2018,118(7):1081-1087.
[3] Chatterjee A, Krishnan NM, Van Vliet MM , et al. A comparison of free autologous breast reconstruction with and without the use of laser-assisted indocyanine green angiography: a cost-effectiveness analysis[J]. Plast Reconstr Surg, 2013,131(5):693e-701e.
[4] Acerbi F, Broggi M, Eoli M , et al. Fluorescein-guided surgery for grade IV gliomas with a dedicated filter on the surgical microscope: preliminary results in 12 cases[J]. Acta Neurochir (Wien) 2013,155(7):1277-1286.
[5] Wang C, Wang Z, Zhao T , et al. Optical molecular imaging for tumor detection and image-guided surgery[J]. Biomaterials, 2018,157:62-75.
[6] Rosenthal EL, Warram JM, de Boer E , et al. Safety and tumor specificity of Cetuximab-IRDye800 for surgical navigation in head and neck cancer[J]. Clin Cancer Res, 2015,21(16):3658-3666.
[7] Day KE, Sweeny L, Kulbersh B , et al. Preclinical comparison of near-infrared-labeled cetuximab and panitumumab for optical imaging of head and neck squamous cell carcinoma[J]. Mol Imaging Biol, 2013,15(6):722-729.
[8] Maeda H . Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity[J]. Adv Drug Deliv Rev, 2015,91:3-6.
[9] Schaafsma BE, Mieog JS, Hutteman M , et al. The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery[J]. Adv Drug Deliv Rev, 2011,104(3):323-332.
[10] Scholl P, Byers RM, Batsakis JG , et al. Microscopic cut-through of cancer in the surgical treatment of squamous carcinoma of the tongue. Prognostic and therapeutic implications[J]. Am J Surg. 1986,152(4):354-360.
[11] Liao CT, Chang JT, Wang HM , et al. Analysis of risk factors of predictive local tumor control in oral cavity cancer[J]. Ann Surg Oncol, 2008,15(3):915-922.
[12] Mahjoub A, Morales-Restrepo A, Fourman MS , et al. Tumor resection guided by intraoperative indocyanine green dye fluorescence angiography results in negative surgical margins and decreased local recurrence in an orthotopic mouse model of osteosarcoma[J]. Ann Surg Oncol, 2019,26(3):894-898.
[13] Ito A, Ohta M, Kato Y , et al. A Real-time near-infrared fluorescence imaging method for the detection of oral cancers in mice using an indocyanine green-labeled podoplanin antibody[J]. Technol Cancer Res Treat, 2018,17:1533-1538.
[14] KleinJan GH, van Werkhoven E, van den Berg NS , et al. The best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes[J]. Eur J Nucl Med Mol Imaging, 2018,45(11):1915-1925.
[15] van den Berg NS, Brouwer OR, Klop WM , et al. Concomitant radio-and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-(99m)Tc-nanocolloid[J]. Eur J Nucl Med Mol Imaging, 2012,39(7):1128-1136.
[16] Christensen A, Juhl K, Charabi B , et al. Feasibility of real-time near-infrared fluorescence tracer imaging in sentinel node biopsy for oral cavity cancer patients[J]. Ann Surg Oncol, 2016,23(2):565-572.
[17] Almadori G, Rigante M, Bussu F , et al. Impact of microvascular free flap reconstruction in oral cavity cancer: our experience in 130 cases[J]. Acta Otorhinolaryngol Ital, 2015,35(6):386-393.
[18] Moyer HR, Losken A . Predicting mastectomy skin flap necrosis with indocyanine green angiography: the gray area defined[J]. Plast Reconstr Surg, 2012,129(5):1043-1048.
[19] Newman MI, Samson MC, Tamburrino JF , et al. Intraoperative laser-assisted indocyanine green angiography for the evaluation of mastectomy flaps in immediate breast reconstruction[J]. J Reconstr Microsurg, 2010,26(7):487-492.
[20] Beckler AD, Ezzat WH, Seth R , et al. Assessment of fibula flap skin perfusion in patients undergoing oromandibular reconstruction: comparison of clinical findings, fluorescein, and indocyanine green angiography[J]. JAMA Facial Plast Surg, 2015,17(6):422-426.
[21] Eguchi T, Kawaguchi K, Basugi A , et al. Intraoperative real-time assessment of blood flow using indocyanine green angiography after anastomoses in free-flap reconstructions[J]. Br J Oral Maxillofac Surg, 2017,55(6):628-630.
[22] Bui DT, Cordeiro PG, Hu QY , et al. Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps[J]. Plast Reconstr Surg, 2007,119(7):2092-2100.
[23] Betz CS, Zhorzel S, Schachenmayr H , et al. Endoscopic measurements of free-flap perfusion in the head and neck region using red-excited indocyanine green: preliminary results[J]. J Plast Reconstr Aesthet Surg, 2009,62(12):1602-1608.
[24] Rao L, Bu LL, Ma L , et al. Platelet-facilitated photothermal therapy of head and neck squamous cell carcinoma[J]. Angew Chem Int Ed Engl, 2018,57(4):986-991.
[25] Nam J, Son S, Ochyl LJ , et al. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer[J]. Nat Commun, 2018,9(1):1074.
[26] Ren S, Cheng X, Chen M , et al. Hypotoxic and rapidly metabolic PEG-PCL-C3-ICG nanoparticles for fluorescence-guided photothermal/photodynamic therapy against OSCC[J]. ACS Appl Mater Interfaces, 2017,9(37):31509-31518.
[27] Ma Y, Liu X, Ma Q , et al. Near-infrared nanoparticles based on indocyanine green-conjugated albumin: a versatile platform for imaging-guided synergistic tumor chemo-phototherapy with temperature-responsive drug release[J]. Onco Targets Ther, 2018,11:8517-8528.
[28] Cai X, Liu B, Pang M , et al. Interfacially synthesized Fe-soc-MOF nanoparticles combined with ICG for photothermal/photodynamic therapy[J]. Dalton Trans, 2018,47(45):16329-16336.
[29] Xue P, Hou M, Sun L , et al. Calcium-carbonate packaging magnetic polydopamine nanoparticles loaded with indocyanine green for near-infrared induced photothermal/photodynamic therapy[J]. Acta Biomate, 2018,81:242-255.
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