Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (2): 123-126.doi: 10.12016/j.issn.2096-1456.2020.02.012

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Research progress on the relationship between enamel-related gene polymorphisms and caries susceptibility

LIU Haotian1,LI Huihui1,LIU Shanshan2()   

  1. 1. Bengbu Medical College, Bengbu 233030, China
    2. Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
  • Received:2018-10-23 Revised:2019-10-09 Online:2020-02-20 Published:2020-02-25
  • Contact: Shanshan LIU E-mail:liushanshancan@163.com

Abstract:

Caries is a frequently occurring oral disease that is caused by chronic, progressive destruction of dental hard tissue. The enamel is the superficial layer of the tooth crown; enamel formation-related genes play an important role in the development of enamel, and enamel demineralization is a prerequisite for the occurrence of caries. Therefore, this paper reviewed the relationship between enamel-related gene polymorphisms and caries susceptibility and its possible mechanisms to provide new ideas for the prevention and treatment of caries. The results of a literature review showed that the gene polymorphisms related to enamel formation may increase or decrease susceptibility to caries by influencing the development and structure of enamel. For example, ENAM rs3796703 CT can increase the susceptibility to caries, and AMBN rs34538475 TT can reduce the susceptibility to caries. In the future, the detection and analysis of polymorphisms related to enamel formation that affect the structure or development of enamel may serve as a clinical method to evaluate the susceptibility of caries, which is of great significance for the early prevention and treatment of the disease.

Key words: enamel, enamel formation, amelogenin, ameloblastin, genetic, polymorphism, dental caries, susceptibility

CLC Number: 

  • R781.1

Table 1

The relationship between enamel-related gene polymorphisms and caries susceptibility"

References Published year Sample size (cases) Age (years) Correlation
Dewang et al [9] 2019 362 2~15 ENAM rs3796703 GA allele
decreases the susceptibility to dental caries
Wang et al [10] 2017 1005 0~4 ENAM rs3796703 CT allele
increases the susceptibility to dental caries
Gerreth et al [11] 2017 96 1~4 AMELX rs17878486 TT allele
increases the susceptibility to dental caries
AMBN rs34538475 TT allele
decreases the susceptibility to dental caries
Filho et al [12] 2017 184 4~7 MMP20 rs1784418 C > T allele
decreases the susceptibility to dental caries
Antunes et al [13] 2016 786 2~6 MMP20 rs1711437 AG allele
MMP9 rs17576 AG allele
increases the susceptibility to dental caries
Gerreth et al [14] 2016 96 1~4 ENAM rs12640848 AG allele
increased the susceptibility to dental caries
Abbasoğlu et al [15] 2015 259 4.6 ± 0.61 KLK4 rs198968 AG allele and GG allele
ENAM rs1264848 GG allele decreased the susceptibility to dental caries
Tannure et al [16] 2012 388 9.03 ± 2.75 MMP20 rs1784418 C > T allele
increases the susceptibility to dental caries
[1] 黄少宏, 李剑波, 范卫华 , 等. 广东省12~15岁人群恒牙龋病抽样调查报告(2015—2016年)[J]. 口腔疾病防治, 2017,25(11):697-701.
Huang SH, Li JB, Fan WH , et al. The Report on permanent dental caries in population aged 12 ~ 15 in Guangdong Province (2015-2016) through sampling survey[J]. J Prev Treat Stomatol Dis, 2017,25(11):697-701.
[2] 于世凤 . 口腔组织病理学[M]. 7版. 北京: 人民卫生出版社, 2012: 35-36.
Yu SF. Oral histopathology [M]. 7 th ed. Bei jing: People′s Medical Publishing House, 2012: 35-36.
[3] Guo J, Lyaruu DM, Takano Y , et al. Amelogenins as potential buffers during secretory-stage amelogenesis[J]. J Dent Res, 2015,94(3):412-420.
[4] Selvam SP, Ponniah I . Expression of ameloblastin in the human tooth germ and ameloblastoma[J]. Oral Dis, 2018,24(8):1538-1544.
[5] Daubert DM, Kelley JL, Udod YG , et al. Human enamel thickness and ENAM polymorphism[J]. Int J Oral Sci, 2016,8(2):93-97.
[6] Robinson C, Hudson J . Tuft protein: protein cross-linking in enamel development[J]. Eur J Oral Sci, 2011,119(Suppl 1):50-54.
[7] Yamazaki H, Tran B, Beniash E , et al. Proteolysis by MMP20 prevents aberrant mineralization in secretory enamel[J]. J Dent Res, 2019,98(4):468-475.
[8] Perez VA, Mangum JE, Hubbard MJ . Direct evidence that KLK4 is a hydroxyapatite-binding protein[J]. Biochem Biophys Res Commun, 2018,495(2):1896-1900.
[9] Dewang Divakar D, Alanazi SAS, Assiri MYA , et al. Association between ENAM polymorphisms and dental caries in children[J]. Saudi J Biol Sci, 2019,26(4):730-735.
[10] Wang MC, Qin M, Xia B . The association of enamelin, lactoferrin, and tumour necrosis factor alpha gene polymorphisms with high caries susceptibility in Chinese children under 4 years old[J]. Arch Oral Biol, 2017,80:75-81.
[11] Gerreth K, Zaorska K, Zabel M , et al. Chosen single nucleotide polymorphisms (SNPs) of enamel formation genes and dental caries in a population of Polish children[J]. Adv Clin Exp Med, 2017,26(6):899-905.
[12] Filho AV, Calixto MS, Deeley K , et al. MMP20 rs1784418 protects certain populations against caries[J]. Caries Res, 2017,51(1):46-51.
[13] Antunes LA, Antunes LS, Küchler EC , et al. Analysis of the association between polymorphisms in MMP2, MMP3, MMP9, MMP20, TIMP1, and TIMP2 genes with white spot lesions and early childhood caries[J]. Int J Paediatr Dent, 2016,26(4):310-319.
[14] Gerreth K, Zaorska K, Zabel M , et al. Association of ENAM gene single nucleotide polymorphisms with dental caries in Polishchildren[J]. Clin Oral Investig, 2016,20(3):631-636.
[15] Abbasoğlu Z, Tanboğa ⅰ, Küchler EC , et al. Early childhood caries is associated with genetic variants in enamel formation and immune response genes[J]. Caries Res, 2015,49(1):70-77.
[16] Tannure PN, Küchler EC, Lips A , et al. Genetic variation in MMP20 contributes to higher caries experience[J]. J Dent, 2012,40(5):381-386.
[17] Borilova Linhartova P, Deissova T, Musilova K , et al. Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children[J]. Clin Oral Investig, 2018,22(4):1873-1877.
[18] Shaffer JR, Carlson JC, Stanley BO , et al. Effects of enamel matrix genes on dental caries are moderated by fluoride exposures[J]. Hum Genet, 2015,134(2):159-167.
[19] Opydo-Szymaczeka J, Gerreth K, Borysewicz-Lewicka M , et al. Enamel defects and dental caries among children attending primary schools in Poznań, Poland[J]. Adv Clin Exp Med, 2018,27(11):1535-1540.
[20] Akkus A, Karasik D, Roperto R . Correlation between micro-hardness and mineral content in healthy human enamel[J]. J Clin Exp Dent, 2017,9(4):e569-e573.
[21] Halusic AM, Sepich VR, Shirley DC , et al. Calcium and Magnesium levels in primary tooth enamel and genetic variation in enamel formation genes[J]. Pediatr Dent, 2014,36(5):384-388.
[22] Pang L, Zhi Q, Zhuang P , et al. Variation in enamel formation genes influences enamel demineralization in vitro in a streptococcus mutans biofilm model[J]. Front Physiol, 2017,8:851.
[23] Bayram M, Deeley K, Reis MF , et al. Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions[J]. Eur J Oral Sci, 2015,123(5):327-334.
[24] Gerreth K, Zaorska K, Zabel M , et al. Significance of genetic variations in developmental enamel defects of primary dentition in Polish children[J]. Clin Oral Investig, 2018,22(1):321-329.
[25] Shahid M, Balto HA, Al-Hammad N , et al. Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis[J]. Eur J Med Genet, 2016,59(8):377-385.
[26] Kwak SY, Yamakoshi Y, Simmer JP , et al. MMP20 proteolysis of native amelogenin regulates mineralization in vitro[J]. J Dent Res, 2016,95(13):1511-1517.
[27] Yamakoshi Y, Simmer JP, Bartlett JD , et al. MMP20 and KLK4 activation and inactivation interactions in vitro[J]. Arch Oral Biol, 2013,58(11):1569-1577.
[28] Kim YJ, Seymen F, Kang J , et al. Candidate gene sequencing reveals mutations causing hypoplastic amelogenesis imperfecta[J]. Clin Oral Investig, 2019,23(3):1481-1487.
[29] Kim YJ, Kim YJ, Kang J , et al. A novel AMELX mutation causes hypoplastic amelogenesis imperfecta[J]. Arch Oral Biol, 2017,76:61-65.
[30] Lu T, Li M, Xu X , et al. Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders[J]. Int J Oral Sci, 2018,10(3):26.
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