Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (3): 189-194.DOI: 10.12016/j.issn.2096-1456.2020.03.010

• Review Articles • Previous Articles     Next Articles

Research progress on the effect of pH-sensitive drug delivery systems on oral microorganisms

PENG Xinyu1,PENG Xian2,CHENG Lei1()   

  1. 1. Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-11-12 Revised:2019-01-11 Online:2020-03-20 Published:2020-03-20
  • Contact: Lei CHENG



  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科,四川 成都(610041)
    2. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心,四川 成都(610041)
  • 通讯作者: 程磊
  • 作者简介:彭鑫钰,医师,在读硕士研究生,Email:
  • 基金资助:


Microorganisms are closely related to the occurrence and development of common oral diseases. Due to the unique physiological and anatomical characteristics of the oral cavity, locally introduced antibacterial drugs cannot be maintained in the effective concentration range under the effect of saliva erosion. Therefore, to enhance the retention and bioavailability of antibacterial drugs in biofilms, some scholars designed pH sensitive drug delivery systems with the fact that the pH value of oral biofilm is lower than the physiological pH value. This article reviews the research reports of a pH-sensitive drug delivery system in the oral cavity and elaborates its application in oral diseases such as dental caries, endodontic disease, periapical disease, peri-implant diseases, and oral candidiasis. Literature review Results show that the pH-sensitive drug delivery system loaded with antibacterial drugs could be used for the control of oral microorganisms with excellent pH sensitivity and antibacterial properties, especially in the application of acid-producing bacteria such as Streptococcus mutans for the prevention and treatment of dental caries. However, the research of pH-sensitive drug delivery systems in the oral cavity is still limited to basic research,and in clinical applications, it still faces many challenges, such as a complex design and synthesis, difficulties with lasting effects and eliminating drug-resistance and persistent bacteria. Further optimization of pH sensitive systems, as well as animal experiments and in vivo studies will be the focus of future research.

Key words: pH sensitive drug delivery, drug delivery system, nanoparticles, oral microorganisms, acid-producing bacteria, Streptococcus mutans, drug-resistance bacteria, biofilms



关键词: pH敏感载药, 药物递送系统, 纳米粒子, 口腔微生物, 产酸菌, 变异链球菌, 耐药菌, 生物膜

CLC Number: