Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (4): 236-240.DOI: 10.12016/j.issn.2096-1456.2020.04.006

• Cinical Study • Previous Articles     Next Articles

Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects

WANG Yamin1,ZHOU Zhen2(),DAO Junfeng3,CHEN Qiyue4,LIU Wenjing3,SONG Guangbao5   

  1. 1. Department of Periodontal Disease, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    2. Implant Center, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    3. Department of Prosthodontics, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    4. Department of Dental Pulp, Haizhu Hospital, Stomatological Hospital, Southern Medical University,Guangzhou 510280, China
    5. Stomatology, Southern Medical University Special Diagnosis Center, Guangzhou 510280, China
  • Received:2019-04-16 Revised:2019-07-18 Online:2020-04-20 Published:2020-03-31
  • Contact: Zhen ZHOU

浓缩生长因子应用于上颌前牙区骨缺损引导骨再生的效果评价

王亚敏1,周震2(),刀俊峰3,陈祈月4,刘文静3,宋光保5   

  1. 1. 南方医科大学口腔医院牙周病科,广东 广州(510280)
    2. 南方医科大学口腔医院种植中心,广东 广州(510280)
    3. 南方医科大学口腔医院修复科,广东 广州(510280)
    4. 南方医科大学口腔医院海珠院区牙体牙髓科,广东 广州(510280)
    5. 南方医科大学口腔医院特诊中心, 广东 广州(510280)
  • 通讯作者: 周震
  • 作者简介:王亚敏,主治医师,硕士,Email:28525791@qq.com
  • 基金资助:
    广东省医学科研基金项目(A2017074);广东省自筹经费类科技计划项目(2017ZC0124);广东省医学科研基金项目(B2018119)

Abstract:

Objective To investigate the clinical effect of concentrated growth factor (CGF) applied in guided bone regeneration (GBR) for severe bone deficiency in the anterior maxilla. Methods Forty patients with bone defects in the anterior maxilla were chosen to be treated with GBR, 20 patients were treated with CGF applied in GBR as the observation group, and the other 20 patients were treated only with GBR as the control group. The evaluation of wound healing was performed after the operation, and bone augmentation was evaluated half a year after the operation. Results The first-stage healing rate of soft tissue wounds in the observation group was 100% and 75% in the control group, and the primary healing rate in the observation group was better than that in the control group (P=0.017). The changes in bone width of the observation group were (3.70 ± 0.28) mm, and those of the control group were (2.96 ± 0.16) mm. The bone augmentation in the observation group was higher than that in the control group (P=0.000). Conclusion CGF applied in GBR has a good effect on bone augmentation for severe bone deficiency in the anterior maxilla.

Key words: concentrated growth factor, tooth loss, anterior teeth, bone defect, bone increment, guided bone regeneration, dental implant, maxilla, wound healing

摘要:

目的 评价浓缩生长因子(concentrated growth factor,CGF)应用于上颌前牙区唇侧骨缺损引导骨再生(guided bone regeneration,GBR)的效果。方法 选取上颌前牙区单牙缺失伴唇侧水平向骨缺损40例,随机分为观察组和对照组各20例。观察组使用浓缩生长因子+骨粉+胶原膜行引导骨再生术;对照组使用骨粉+胶原膜行常规引导骨再生术。术后行软组织愈合评估,术后半年评价骨增量的效果。结果 观察组软组织伤口一期愈合率为100%,对照组为75%,观察组高于对照组,差异具有统计学意义(P=0.017)。观察组术后半年骨宽度增加量为(3.70 ± 0.28)mm,对照组为(2.96 ± 0.16)mm,观察组骨增量大于对照组,差异具有统计学意义(P=0.000)。结论 CGF能促进上颌前牙区骨缺损引导骨再生术的成骨量。

关键词: 浓缩生长因子, 牙缺失, 前牙, 骨缺损, 骨增量, 引导骨再生, 牙种植, 上颌骨, 伤口愈合

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