Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (4): 236-240.doi: 10.12016/j.issn.2096-1456.2020.04.006

• Cinical Study • Previous Articles     Next Articles

Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects

WANG Yamin1,ZHOU Zhen2(),DAO Junfeng3,CHEN Qiyue4,LIU Wenjing3,SONG Guangbao5   

  1. 1. Department of Periodontal Disease, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    2. Implant Center, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    3. Department of Prosthodontics, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    4. Department of Dental Pulp, Haizhu Hospital, Stomatological Hospital, Southern Medical University,Guangzhou 510280, China
    5. Stomatology, Southern Medical University Special Diagnosis Center, Guangzhou 510280, China
  • Received:2019-04-16 Revised:2019-07-18 Online:2020-04-20 Published:2020-03-31
  • Contact: Zhen ZHOU E-mail:chouzhen83@qq.com

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Abstract:

Objective To investigate the clinical effect of concentrated growth factor (CGF) applied in guided bone regeneration (GBR) for severe bone deficiency in the anterior maxilla. Methods Forty patients with bone defects in the anterior maxilla were chosen to be treated with GBR, 20 patients were treated with CGF applied in GBR as the observation group, and the other 20 patients were treated only with GBR as the control group. The evaluation of wound healing was performed after the operation, and bone augmentation was evaluated half a year after the operation. Results The first-stage healing rate of soft tissue wounds in the observation group was 100% and 75% in the control group, and the primary healing rate in the observation group was better than that in the control group (P=0.017). The changes in bone width of the observation group were （3.70 ± 0.28） mm, and those of the control group were （2.96 ± 0.16） mm. The bone augmentation in the observation group was higher than that in the control group (P=0.000). Conclusion CGF applied in GBR has a good effect on bone augmentation for severe bone deficiency in the anterior maxilla.

Key words: concentrated growth factor, tooth loss, anterior teeth, bone defect, bone increment, guided bone regeneration, dental implant, maxilla, wound healing

CLC Number: 

  • R78

Figure 1

Preparation of CGF a: extracting liquid CGF; b: generating CGF film; c: pressing CGF film;CGF: concentrated growth facto"

Figure 2

Application of CGF to guide bone regeneration in the maxillary anterior teeth a: exposure of the operation area; b: collagen membrane of the bone graft cover; c: CGF membrane of the cover; CGF: concentrated growth factor"

Figure 3

Application of CGF to guide bone regeneration and soft tissue healing a: healing was the primary intention in the observation group; b: healing was the secondary intention in the control group; CGF: concentrated growth factor"

Figure 4

The effect of CGF guided bone regeneration in the observation group was better than the control group a-c： effect of CGF-guided bone regeneration before, immediately after and 6 months after operation in the observation group; d-f： effect of guided bone regeneration before, immediately after and 6 months after the operation in the control group; CGF: concentrated growth factor"

Table 1

Alveolar ridge width before and after operation and bone augmentation in the two groups x ± s, mm"

Observation group Control group t P
Width of the alveolar ridge before operation 2.37 ± 0.35 2.42 ± 0.37 -0.41 0.688
Width of the alveolar ridge after operation 6.07 ± 0.38 5.38 ± 0.41 5.53 < 0.001
Variation of the bone width 3.70 ± 0.28 2.96 ± 0.16 10.01 < 0.001
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