Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects

doi:10.12016/j.issn.2096-1456.2020.04.006

Abstract

Abstract:

Objective To investigate the clinical effect of concentrated growth factor (CGF) applied in guided bone regeneration (GBR) for severe bone deficiency in the anterior maxilla. Methods Forty patients with bone defects in the anterior maxilla were chosen to be treated with GBR, 20 patients were treated with CGF applied in GBR as the observation group, and the other 20 patients were treated only with GBR as the control group. The evaluation of wound healing was performed after the operation, and bone augmentation was evaluated half a year after the operation. Results The first-stage healing rate of soft tissue wounds in the observation group was 100% and 75% in the control group, and the primary healing rate in the observation group was better than that in the control group (P=0.017). The changes in bone width of the observation group were （3.70 ± 0.28） mm, and those of the control group were （2.96 ± 0.16） mm. The bone augmentation in the observation group was higher than that in the control group (P=0.000). Conclusion CGF applied in GBR has a good effect on bone augmentation for severe bone deficiency in the anterior maxilla.

Key words: concentrated growth factor, tooth loss, anterior teeth, bone defect, bone increment, guided bone regeneration, dental implant, maxilla, wound healing

摘要：

目的评价浓缩生长因子（concentrated growth factor,CGF）应用于上颌前牙区唇侧骨缺损引导骨再生（guided bone regeneration,GBR）的效果。方法选取上颌前牙区单牙缺失伴唇侧水平向骨缺损40例,随机分为观察组和对照组各20例。观察组使用浓缩生长因子+骨粉+胶原膜行引导骨再生术;对照组使用骨粉+胶原膜行常规引导骨再生术。术后行软组织愈合评估,术后半年评价骨增量的效果。结果观察组软组织伤口一期愈合率为100%,对照组为75%,观察组高于对照组,差异具有统计学意义（P=0.017）。观察组术后半年骨宽度增加量为（3.70 ± 0.28）mm,对照组为（2.96 ± 0.16）mm,观察组骨增量大于对照组,差异具有统计学意义（P=0.000）。结论 CGF能促进上颌前牙区骨缺损引导骨再生术的成骨量。

关键词: 浓缩生长因子, 牙缺失, 前牙, 骨缺损, 骨增量, 引导骨再生, 牙种植, 上颌骨, 伤口愈合

CLC Number:

WANG Yamin,ZHOU Zhen,DAO Junfeng,CHEN Qiyue,LIU Wenjing,SONG Guangbao. Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(4): 236-240.

王亚敏,周震,刀俊峰,陈祈月,刘文静,宋光保. 浓缩生长因子应用于上颌前牙区骨缺损引导骨再生的效果评价[J]. 口腔疾病防治, 2020, 28(4): 236-240.

Figures/Tables 5

Figure 1 Preparation of CGF a: extracting liquid CGF; b: generating CGF film; c: pressing CGF film;CGF: concentrated growth facto

Figure 2 Application of CGF to guide bone regeneration in the maxillary anterior teeth a: exposure of the operation area; b: collagen membrane of the bone graft cover; c: CGF membrane of the cover; CGF: concentrated growth factor

Figure 3 Application of CGF to guide bone regeneration and soft tissue healing a: healing was the primary intention in the observation group; b: healing was the secondary intention in the control group; CGF: concentrated growth factor

Figure 4 The effect of CGF guided bone regeneration in the observation group was better than the control group a-c： effect of CGF-guided bone regeneration before, immediately after and 6 months after operation in the observation group; d-f： effect of guided bone regeneration before, immediately after and 6 months after the operation in the control group; CGF: concentrated growth factor

Table 1 Alveolar ridge width before and after operation and bone augmentation in the two groups x ± s, mm

	Observation group	Control group	t	P
Width of the alveolar ridge before operation	2.37 ± 0.35	2.42 ± 0.37	-0.41	0.688
Width of the alveolar ridge after operation	6.07 ± 0.38	5.38 ± 0.41	5.53	< 0.001
Variation of the bone width	3.70 ± 0.28	2.96 ± 0.16	10.01	< 0.001

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