Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (5): 322-326.DOI: 10.12016/j.issn.2096-1456.2020.05.010

• Review Articles • Previous Articles     Next Articles

Research progress on animal models of oral mucositis caused by radiotherapy and chemotherapy

ZOU Xiaolong1,CHEN Yuan1,WANG Yan1,WANG Jiantao2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    2. State key Laboratory of Biotherapy & Department of Lung Cancer Center and Department of Radiation Oncology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2019-02-15 Revised:2019-11-23 Online:2020-05-20 Published:2020-04-24
  • Contact: Jiantao WANG

放化疗性口腔黏膜炎动物模型研究进展

邹晓龙1,陈媛1,王艳1,王建涛2()   

  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院,四川 成都(610041)
    2. 生物治疗国家重点实验室 四川大学华西医院肺癌中心 四川大学华西医院放疗中心,四川 成都(610041)
  • 通讯作者: 王建涛
  • 作者简介:邹晓龙,学士,Email: 1498181973@qq.com
  • 基金资助:
    国家自然科学基金项目(81600864,四川省卫计委基金普及项目18PJ186)

Abstract:

Inflammation of the oral mucosa induced by radiotherapy and/or chemotherapy may cause pain, difficulty speaking and swallowing, an increased risk of local and systemic infections, and even interrupt cancer treatment, which can seriously affect a patient′s quality of life. The pathogenesis of oral mucositis is complicated. There is still a lack of prevention and treatment modalities for oral mucositis in the clinic. Animal models play a vital role in exploring the pathogenesis of oral mucositis and developing better prevention and treatment methods. This article reviews the current research progress on the establishment and assessment of animal models of oral mucositis. The literature review results showed that animal models of oral mucositis have been established, such as mouse, rat, and gold hamster models. In the replication of animal models, radiotherapy-induced oral mucositis is generally induced by local single-dose or fractionated irradiation using X-ray equipment, either alone or in combination with the chemotherapy drugs 5-fluorouracil or cisplatin; cesium can also be used used as a radioactive source for local irradiation. Oral mucositis induced by the chemotherapy drug 5-fluorouracil alone is generally mild, so 5-fluorouracil was combined with mechanical trauma or acetic acid. The main methods for assessing oral mucositis are gross observation as well as histopathological observation.

Key words: oral mucositis, radiotherapy, chemotherapy, animal model, assessment, mouse, rat, 5-fluorouracil, cesium

摘要:

由放疗和(或)化疗诱发的口腔黏膜炎症,可能导致患者疼痛、说话吞咽困难、局部和全身感染风险增高,甚至中断抗癌治疗,严重影响患者生活质量。放化疗性口腔黏膜炎的发病机制复杂而且防治较为困难,而动物模型在探究放化疗性口腔黏膜炎的发病机制以及探索更好的防治方法中发挥了重要作用,本文就以现有的放化疗性口腔黏膜炎动物模型的复制及评估方法予以综述。文献复习结果表明,国内外采用小鼠、大鼠、金仓鼠等动物来复制动物模型;放疗诱发的口腔黏膜炎的诱导方法有仅采用X射线设备对动物进行局部单剂量照射或局部分割照射,或照射时辅助使用化疗药物5-氟尿嘧啶或顺铂,也可以采用 137铯作为放射源进行局部照射;单纯使用化疗药物5-氟尿嘧啶诱发的口腔黏膜炎一般症状较轻,因此多采用5-氟尿嘧啶联合机械刺激或乙酸进行诱导;评估放化疗性口腔黏膜炎的方法主要为大体样本观察及组织病理学观察。

关键词: 口腔黏膜炎, 放疗, 化疗, 动物模型, 评估方法, 小鼠, 大鼠, 5-氟尿嘧啶,

CLC Number: