Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (7): 427-432.DOI: 10.12016/j.issn.2096-1456.2020.07.004
• Basic Study • Previous Articles Next Articles
CAO Shunshun,WANG Xiaolong(),SHU Chuanji,SHAO Jianjie
Received:
2019-03-15
Revised:
2020-01-02
Online:
2020-07-20
Published:
2020-06-04
Contact:
Xiaolong WANG
通讯作者:
汪晓龙
作者简介:
曹顺顺,主治医师,硕士,Email:3324851803@qq.com
基金资助:
CLC Number:
CAO Shunshun,WANG Xiaolong,SHU Chuanji,SHAO Jianjie. Inhibitory effect of celecoxib on Cal-27 tongue squamous cell carcinoma cell proliferation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 427-432.
曹顺顺,汪晓龙,舒传继,邵剑杰. 塞莱昔布对舌鳞癌细胞Cal-27增殖的抑制作用[J]. 口腔疾病防治, 2020, 28(7): 427-432.
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Figure 2 The effect of different concentrations of CELE on Cal-27 cell invasion (× 200) a: 10 μmol/L CELE group; b: 20 μmol/Lμmol/L CELE group; c: 40 μmol/L CELE group; d: the control group e: #: vs. the control group, P <0.05, ##: vs. the control group, P < 0.01; CELE: celecoxib
Figure 3 The effect of CELE on c-Myc, Cyclin D1 mRNA expression in Cal-27 cells #: vs. the control group, P < 0.05, ##: vs. the control group, P < 0.01; CELE: celecoxib
Figure 4 Effects of different concentrations of CELE on the expression of cell proliferation related proteins PTEN, p-Akt (Thr308), c-Myc and cyclin D1 in Cal-27 cells #: vs. the control group, P <0.05, ##: vs. the control group, P < 0.01; CELE: celecoxib; PTEN: phosphate and tension homology deleted on chromsome ten; p-AKT: phospho-protein kinase B
Figure 5 Effects of 40 μmol/L CELE on the expression of PTEN, p-Akt (Thr308), c-Myc and cyclin D1 in Cal-27 cells at different time #: vs. the control group, P <0.05, ##: vs. the control group, P < 0.01; CELE: celecoxib; PTEN: phosphate and tension homology deleted on chromsome ten; p-AKT: phospho-protein kinase B
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