Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (8): 510-513.doi: 10.12016/j.issn.2096-1456.2020.08.006

• Cinical Study • Previous Articles     Next Articles

Clinical report of cheek mass after injection and filling of hyaluronic acid in the cheek

LI Ming1,YAN Xingquan2,NAN Xinrong1,2()   

  1. 1. School of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2. Department of Stomatology, The First Hospital, Shanxi Medical University, Taiyuan 030001, China
  • Received:2019-10-30 Revised:2020-04-13 Online:2020-08-20 Published:2020-07-15
  • Contact: Xinrong NAN E-mail:xr_nan@sina.com

Abstract:

Objective To investigate the clinical characteristics, differential diagnosis and treatment of cheek mass caused by hyaluronic acid injection. Methods From March 2014 to December 2018, data from 5 patients with cheek masses caused by cosmetic fillings admitted to the First Hospital of Shanxi Medical University were collected, and their clinical, imaging, surgical and pathological features were summarized. Results All 5 patients were young females with a history of facial hyaluronic acid filling injection. Their clinical features were buccal and facial nodular masses, all of which were treated with surgery. The pathological report was fibrous adipose tissue with fat necrosis, and chronic inflammatory cell infiltration was observed in the interstitium. After the operation, the face shape was basically symmetrical, and there were no symptoms such as infection, limited mouth opening or facial paralysis. Conclusion The injection of facial hyaluronic acid may cause complications of nodular masses in the cheek, and intraoral resection is an effective treatment with good prognosis.

Key words: hyaluronic acid, filling injection, complications, cheek mass, fibrous adipose tissue, fat necrosis, chronic inflammatory

CLC Number: 

  • R78

Table 1

Clinical data of 5 patients"

Number Age(year) Sex HA injection history Mass site Symptom Clinical sign
Injection time Drug brand
1 36 Female 4 years ago Unknown Right cheek Right cheek mass with pain Mass is medium texture; sticky and haphalgesia
2 28 Female 3 years ago Unknown Left cheek Left cheek mass; no obvious discomfort Mass is soft texture; no adhesion and haphalgesia
3 30 Female 1 year ago Unknown Bilateral cheek Bilateral cheek mass; no obvious discomfort Mass is soft texture; no adhesion and haphalgesia
4 25 Female 3 years ago Unknown Left cheek Left cheek mass; no obvious discomfort Mass is medium texture; no adhesion and haphalgesia
5 34 Female 1 year ago Unkown Bilateral cheek Bilateral cheek mass; no obvious discomfort Mass is soft texture; no adhesion and haphalgesia

Figure 1

MRI, intraoperative tumor status and pathological biopsy of cheek mass a: MRI in the coronal position; b: cross-sectional MRI, white square shows a space-occupying lesion in the left buccal region, and the mass has unclear boundaries of surrounding tissue; c: intraoperative masses were observed to be adherent to the buccal fat pad, with clear boundaries to the muscles and submucosal surrounding tissues; d: the mass was approximately 3.5 cm long, yellow in color and medium in texture with shape irregularities; e: pathological section of the mass (HE × 40), black arrow shows a large number of fat cells with a small amount of inflammatory cells; f: pathological section of the mass (HE × 400), black arrow shows adipocyte intercellular hybrid foam cells"

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