Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (8): 535-539.doi: 10.12016/j.issn.2096-1456.2020.08.011

• Review Articles • Previous Articles     Next Articles

Research progress of sonodynamic therapy in the field of stomatology

XU Bin,BI Liangjia()   

  1. Department of Stomatology, the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001, China
  • Received:2019-04-07 Revised:2020-03-13 Online:2020-08-20 Published:2020-07-15
  • Contact: Liangjia BI E-mail:Biliangjia66@163.com

Abstract:

Sonodynamic therapy (SDT) is a cutting-edge method for the biological effects of ultrasound combined with sound-sensitive agents. In recent years, SDT has been a concern of experts and scholars in the oral field, and a series of experimental studies has been carried out. We will introduce the progress of SDT in the field of stomatology from three aspects: the therapeutic mechanism of SDT, the application of SDT in the oral field, and the current situation and future of SDT in the treatment of oral diseases. It is currently believed that singlet oxygen theory, cavitation effects, and induction of apoptosis are the main therapeutic mechanisms. The research of SDT on oral disease prevention mainly focuses on oral tumors (especially squamous cell carcinoma and osteosarcoma) and infectious diseases (such as periodontitis, maxillofacial infection, and oral mucosal disease). Although the current research is still in the experimental stage, with the continuous exploration of sonosensitizers and nanotechnology, SDT will provide great help for the clinical prevention and treatment of oral diseases in the future.

Key words: sonodynamic therapy, ultrasound, sonosensitizer, singlet oxygen theory, cavitation effects, apoptosis, periodontitis, oral tumor, oral mucosal disease, nanoparticles

CLC Number: 

  • R781.05
[1] Liu RG, Zhang QY, Lang YH, et al. Sonodynamic therapy, a treatment developing from photodynamic therapy[J]. Photodiagnosis Photodyn Ther, 2017,19:159-166.
doi: 10.1016/j.pdpdt.2017.06.003 pmid: 28606724
[2] Qian XQ, Zheng YY, Chen Y. Micro/nanoparticle-augmented sonodynamic therapy(SDT): breaking the depth shallow of photoactivation[J]. Adv Mater, 2016,28(37):8097-8129.
doi: 10.1002/adma.201602012 pmid: 27384408
[3] Onyango AN. Endogenous generation of singlet oxygen and ozone in human and animal tissues: mechanisms, biological significance, and influence of dietary components[J]. Oxid Med Cell Longev, 2016,2016:2398573.
doi: 10.1155/2016/2398573 pmid: 27042259
[4] Wang XJ, Meng GQ, Zhang S, et al. A reactive1O2-responsive combined treatment system of photodynamic and chemotherapy for cancer [J]. Sci Rep, 2016,6:29911.
doi: 10.1038/srep29911 pmid: 27443831
[5] Li XS, Gao L, Zheng LB, et al. The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamictherapy in THP-1 macrophages[J]. Int J Nanomedicine, 2015,10:821-838.
doi: 10.2147/IJN.S75398 pmid: 25653524
[6] Schiffer A, Gardner MN, Lynn RH, et al. A new apparatus to induce lysis of planktonic microbial cells by shock compression, cavitation and spray[J]. R Soc Open Sci, 2017,4(3):160939.
[7] Wood AK, Sehgal CM. A review of low-intensity ultrasound for cancer therapy[J]. Ultrasound Med Biol, 2015,41(4):905-928.
doi: 10.1016/j.ultrasmedbio.2014.11.019 pmid: 25728459
[8] Wang XB, Wang P, Zhang K, et al. Initiation of autophagy and apoptosis by sonodynamic therapy in murine leukemia L1210 cells[J]. Toxicol In Vitro, 2013,27(4):1247-1259.
[9] Zheng XF, Wu JR, Shao Q, et al. Apoptosis of THP-1 macrophages induced by pseudohypericin-mediated sonodynamic therapy through the mitochondria-caspase pathway[J]. Cell Physiol Biochem, 2016,38(2):545-557.
pmid: 26828938
[10] Yumita N, Watanabe T, Chen FS, et al. Induction of apoptosis by functionalized fullerene-based sonodynamic therapy in HL-60 cells[J]. Anticancer Res, 2016,36(6):2665-2674.
pmid: 27272775
[11] Huang GP, Chen SW, Dai CH, et al. Effects of ultrasound on microbial growth and enzyme activity[J]. UltrasonSonochem, 2017,37:144-149.
[12] Goertz DE. An overview of the influence of therapeutic ultrasound exposures on the vasculature: high intensity ultrasound and microbubble-mediated bioeffects[J]. Int J Hyperthermia, 2015,31(2):134-144.
pmid: 25716770
[13] Hersh DS, Kim AJ, Winkles JA, et al. Emerging applications of therapeutic ultrasound in neuro-oncology: moving beyond tumor ablation[J]. Neurosurgery, 2016,79(5):643-654.
doi: 10.1227/NEU.0000000000001399 pmid: 27552589
[14] Zhang QY, Bao CX, Cai XJ, et al. Sonodynamic therapy-assisted immunotherapy: a novel modality for cancer treatment[J]. Cancer Sci, 2018,109(5):1330-1345.
pmid: 29575297
[15] Trendowski M. Using the promise of sonodynamic therapy in the clinical setting against disseminated cancers[J]. Chemother Res Pract, 2015,2015:316015.
doi: 10.1155/2015/316015 pmid: 26380110
[16] 崔海东, 吕岩红, 曹斌, 等. 低强度超声联合原卟啉IX诱导人舌鳞癌SAS细胞凋亡作用的研究[J]. 口腔医学研究, 2011,27(7):580-582.
Cui HD, Lv YH, Cao B , et al. Low-intensity ultrasound combined with protoporphyrin IX induced apoptosis on human tongue cancer cell Line SAS[J]. J Oral Sci Res, 2011,27(7):580-582.
[17] Lv YH, Zheng JH, Zhou Q, et al. Antiproliferative and apoptosis-inducing effect of exo-protoporphyrin IX based sonodynamic therapy on human oral squamous cell carcinoma[J]. Sci Rep, 2017,7:40967.
doi: 10.1038/srep40967 pmid: 28102324
[18] Fan HX, Li HX, Liu GY, et al. Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts[J]. J Exp Clin Cancer Res, 2017,36(1):163.
doi: 10.1186/s13046-017-0633-y pmid: 29157266
[19] Li HX, Yang D, Chen H, et al. Effects of low-intensity ultrasound combined with low-dose carboplatin in an orthotopic hamster model of tongue cancer: a preclinical study[J]. Oncol Rep, 2018,39(4):1609-1618.
doi: 10.3892/or.2018.6262 pmid: 29436690
[20] Moosavi Nejad S, Takahashi H, Hosseini H, et al. Acute effects of sono-activated photocatalytic titanium dioxide nanoparticles on oral squamous cell carcinoma[J]. Ultrason Sonochem, 2016,32:95-101.
doi: 10.1016/j.ultsonch.2016.02.026 pmid: 27150750
[21] Canaves G, Ancona A, Raccca L, et al. Nanoparticle-assisted ultrasound: a special focus on sonodynamic therapy against cancer[J]. Chem Eng J, 2018,340:155-172.
doi: 10.1016/j.cej.2018.01.060
[22] Carina V, Costa V, Sartori M, et al. Adjuvant biophysical therapies in osteosarcoma[J]. Cancers (Basel), 2019 , 11(3):348.
doi: 10.3390/cancers11030348
[23] Li YN, Zhou Q, Hu Z, et al. 5-Aminolevulinic acid-based sonodynamic therapy induces the apoptosis of osteosarcoma in mice[J]. PLoS One, 2015,10(7):e0132074.
doi: 10.1371/journal.pone.0132074 pmid: 26161801
[24] Liu B, Wang DJ, Liu BM, et al. The influence of ultrasound on the fluoroquinolones antibacterial activity[J]. Ultrason Sonochem, 2011,18(5):1052-1056.
doi: 10.1016/j.ultsonch.2011.02.001 pmid: 21353619
[25] Harris F, Dennison SR, Phoenix DA. Sounding the death knell for microbes[J]. Trends in Molecular Medicine, 2014,20:363-367.
pmid: 24928236
[26] Zhuang DS, Han JL, Bi LJ, et al. Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-indued periodontitis in rats[J]. Drug Des Dev Ther, 2015,6(9):2545-2551.
[27] Nakonechny F, Nisnevitch M, Nitzan Y, et al. Sonodynamic excitation of rose bengal for eradication of gram-positive and gram-negative bacteria[J]. Biomed Res Int, 2013,11(19):684-930.
[28] Wan GY, Liu Y, Chen BW, et al. Recent advances of sonodynamic therapy in cancer treatment[J]. Cancer Biol Med, 2016,13(3):325-338.
doi: 10.20892/j.issn.2095-3941.2016.0068 pmid: 27807500
[29] Seil JT, Webster TJ. Antibacterial effect of zinc oxide nanoparticles combined with ultrasound[J]. Nanotechnology, 2012,23(49):495101-495109.
pmid: 23149720
[30] Costley D, Nesbitt H, Ternan N, et al. Sonodynamic inactivation of Gram-positive and Gram-negative bacteria using a rose bengal-antimicrobial peptide conjugate[J]. Int J Antimicrob Ag, 2017,49(1):31-36.
doi: 10.1016/j.ijantimicag.2016.09.034
[31] Shevchenko SN, Burkhardt M, Sheval EV, et al. Antimicrobial effect of biocompatible silicon nanoparticles activated by therapeutic ultrasound[J]. Langmuir, 2017,33(10):2603-2609.
pmid: 28211702
[32] Xu C, Dong J, Ip M, et al. Sonodynamic action of chlorin e6 on Staphylococcus aureus and Escherichia coli[J]. Ultrasonics, 2016,64(1):54-57.
doi: 10.1016/j.ultras.2015.07.010
[33] Alves F, Pavarina AC, Mima EGO, et al. Antimicrobial sonodynamic and photodynamic therapies against Candida albicans[J]. Biofouling, 2018,34(4):357-367.
doi: 10.1080/08927014.2018.1439935 pmid: 29671631
[34] Yang M, Xie S, Adhikari VP, et al. The synergistic fungicidal effect of low-frequency and low-intensity ultrasound with amphotericin B-loaded nanoparticles on C. albicans in vitro[J]. Int J Pharm, 2018,542(1-2):232-241.
doi: 10.1016/j.ijpharm.2018.03.033 pmid: 29559330
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