Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (10): 668-672.doi: 10.12016/j.issn.2096-1456.2020.10.010

• Review Articles • Previous Articles     Next Articles

Research progress on periodontal regeneration of replanted teeth after complete avulsion

GAO Juan1(),ZUO Wen1,WANG Xuan1,2()   

  1. 1. Department of Pediatric Dentistry and Oral Protection, the First Affiliated Hospital of Xinjiang Medical University, Affiliated Stomatological Hospital of Xinjiang Medical University, Urumqi 830000, China
    2. Xinjiang Uygur Autonomous Region Institution of Stomatology, Urumqi 830000, China
  • Received:2019-10-27 Revised:2020-03-01 Online:2020-10-20 Published:2020-09-01
  • Contact: Xuan WANG E-mail:572827269@qq.com;wangjieqiu126@sina.com

Abstract:

Complete avulsion of teeth are one of the most serious traumatic dental injuries. The preferred treatment is tooth replantation. When teeth usually cannot be treated in time, the periodontal membrane on the root surface becomes necrotic , and the success rate of replantation is greatly reduced. How to use seed cells, growth factors and scaffold materials to promote periodontal tissue regeneration, improve periodontal membrane healing of replanted teeth, and achieve successful replantation of completely dislocated teeth is an urgent problem. Periodontal ligament stem cells (PDLSCs) express stem cell markers, have the potential to undergo multicellular differentiation and have important application value in periodontal tissue regeneration and repair. Fibroblast growth factor-2 (FGF-2), basic fibroblast growth factor (bFGF), lysobisphosphatidic acids (LPA) and other related regulatory factors promote periodontal tissue regeneration. Seed cells combined with scaffold materials can promote periodontal tissue regeneration and repair periodontal tissue defects. At present, studies have shown that PDLSCs and other seed cells have the potential for periodontal tissue regeneration and have been widely studied in experimental animal models of periodontitis and bone defects. However, there are few reports on the application of replanted teeth after complete avulsion, and its mechanism is not clear. In this paper, the research progress of periodontal tissue regeneration after total dislocation replantation is reviewed. We expect to apply periodontal tissue regeneration research to the replantation of fully dislocated teeth to achieve periodontal membrane healing of fully dislocated replanted teeth to provide a theoretical basis for future clinical work.

Key words: traumatic dental injuries, completely avulsion teeth, tooth replantation, periodontal healing, periodontal ligament regeneration, stem cells, periodontal ligament stem cells, related regulatory factors, fibroblast growth factor-2, lysobisphosphatidic acids, scaffolds

CLC Number: 

  • R78
[1] Flores MT, Andersson L, Andreasen JO, et al. Guidelines for the management of traumatic dental injuries. I. Fractures and luxations of permanent teeth[J]. Endod Topics, 2006, 14(1): 102-110. [2]
[2] Bratteberg M, Thelen DS, Klock KS, et al. Traumatic dental injuries-prevalence and severity among 16-year-old pupils in western Norway[J]. Dent Traumatol, 2018,34(3):144-150.
doi: 10.1111/edt.12399 pmid: 29569840
[3] Hegde R, Agrawal G. Prevalence of traumatic dental injuries to the permanent anterior teeth among 9-to 14-year-old schoolchildren of Navi Mumbai(Kharghar-Belapur region), India[J]. Int J Clin Pediatr Dent, 2017,10(2):177-182.
doi: 10.5005/jp-journals-10005-1430 pmid: 28890619
[4] Hasanuddin S, Reddy JS. Sequelae of delayed replantation of maxillary permanent incisors after avulsion: a case series with 24-month follow-up and clinical review[J]. J Indian Soc Pedod Prev Dent, 2018,36(4):410-416.
doi: 10.4103/JISPPD.JISPPD_187_18 pmid: 30324935
[5] Seo BM, Miura M, Gronthos S, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament[J]. Lancet, 2004,364(9429):149-155.
doi: 10.1016/S0140-6736(04)16627-0 pmid: 15246727
[6] Iwasaki K, Komaki M, Akazawa K, et al. Spontaneous differentiation of periodontal ligament stem cells into myofibroblast during ex vivo expansion[J]. J Cell Physiol, 2019,234(11):20377-20391.
doi: 10.1002/jcp.28639 pmid: 30963561
[7] 叶青松, 王晓燕. 牙源性干细胞储存和临床应用的研究进展[J]. 口腔疾病防治, 2018,26(1):15-25.
Ye QS, Wang XY. Research progress of odontogenic stem cell storage and clinical application[J]. J Prev Treat Stomatol Dis, 2018,26(1):15-25.
[8] Bakopoulou A, About I. Stem cells of dental origin: current research trends and key milestones towards clinical application[J]. Stem Cells Int, 2016(2016):4209891.
[9] Jin Q, Yuan K, Lin W, et al. Comparative characterization of mesenchymal stem cells from human dental pulp and adipose tissue for bone regeneration potential[J]. Artif Cells Nanomed Biotechnol, 2019,47(1):1577-1584.
doi: 10.1080/21691401.2019.1594861 pmid: 31027424
[10] Sang-Joun Y, Jung-Seok L, Ui-Won J, et al. Effect of fibroblast growth factor on injured periodontal ligament and cementum after tooth replantation in dogs[J]. J Periodontal Implant, 2015,45(3):111-119.
[11] Kang W, Liang Q, Du L, et al. Sequential application of bFGF and BMP-2 facilitates osteogenic differentiation of human periodontal ligament stem cells[J]. J Periodontal Res, 2019,54(4):424-434.
doi: 10.1111/jre.12644 pmid: 30851068
[12] Xu M, Wei X, Fang J, et al. Combination of SDF-1 and bFGF promotes bone marrow stem cell-mediated periodontal ligament regeneration[J]. Biosci Rep, 2019, 39(12): BSR20190785.
doi: 10.1042/BSR20191301 pmid: 31803921
[13] Aikawa S, Hashimoto T, Kano K, et al. Lysophosphatidic acid as a lipid mediator with multiple biological actions[J]. J Biochem, 2015,157(2):81-89.
doi: 10.1093/jb/mvu077 pmid: 25500504
[14] Kim BC, Song JI, So KH, et al. Effects of lysophosphatidic acid on human periodontal ligament stem cells from teeth extracted from dental patients[J]. J Biomed Res, 2019,33(2):122-130.
doi: 10.7555/JBR.32.20170123 pmid: 31010961
[15] Cerutis DR, Weston MD, Alnouti Y, et al. A major human oral lysophosphatidic acid species, LPA 18∶1, regulates novel genes in human gingival fibroblasts[J]. J Periodontol, 2015,86(5):713-725.
doi: 10.1902/jop.2015.140592 pmid: 25660500
[16] Sugaya T, Tomita M, Motoki Y, et al. Influence of enamel matrix derivative on healing of root surfaces after bonding treatment and intentional replantation of vertically fractured roots[J]. Dent Traumatol, 2016,32(5):397-401.
doi: 10.1111/edt.12270 pmid: 26996758
[17] Zou R, Wan W, Li J, et al. Combining enamel matrix proteins with mechanical stimuli potentiates human periodontal ligament fibroblasts proliferation and periodontium remodeling[J]. Histol Histopathol, 2018,33(8):825-833.
doi: 10.14670/HH-11-978 pmid: 29485179
[18] Narazaki M, Kishimoto T, et al. The two-faced cytokine IL-6 in host defense and diseases[J]. Int J Mol Sci, 2018,19(11):3528.
[19] Liu OS, Xu JJ, Ding G, et al. Periodontal ligament stem cells regulate B lymphocyte function via programmed cell death protein1[J]. Stem Cells, 2013,31(7):1371-1382.
doi: 10.1002/stem.1387 pmid: 23553748
[20] Zhang D, Chia C, Jiao X, et al. D-mannose induces regulatory T cells and suppresses immunopathology[J]. Nat Med, 2017,23(9):1036-1045.
doi: 10.1038/nm.4375 pmid: 28759052
[21] Guo L, Hou Y, Song L, et al. D-mannose enhanced immunomodulation of periodontal ligament stem cells via inhibiting IL-6 secretion[J]. Stem Cells Int, 2018,2018:7168231.
doi: 10.1155/2018/7168231 pmid: 30271438
[22] Hashemi-Beni B, Khoroushi M, Foroughi MR, et al. Tissue engineering:dentin-pulp complex regeneration approaches[J]. Tissue Cell, 2017,49(5):552-564.
doi: 10.1016/j.tice.2017.07.002 pmid: 28764928
[23] Yang JM, Yang KI, Lee KH, et al. Effects of platelet-rich plasma on tooth replantation in dogs:a histologic and histomorphometric analysis[J]. J Periodontal Implant Sci, 2018,48(4):224-235.
doi: 10.5051/jpis.2018.48.4.224 pmid: 30202606
[24] Du J, Mei S, Guo L, et al. Platelet-rich fibrin/aspirin complex promotes alveolar bone regeneration in periodontal defect in rats[J]. J Periodontal Res, 2018,53(1):47-56.
doi: 10.1111/jre.12485 pmid: 28862325
[25] Nagy K, Láng O, Láng J, et al. A novel hydrogel scaffold for periodontal ligament stem cells[J]. Interv Med Appl Sci, 2018,10(3):162-170.
doi: 10.1556/1646.10.2018.21 pmid: 30713756
[1] MA Lingzhi,SHI Jiaozhuang,GE Wenbin,ZHANG Kun,YU Bing,LIU Yali. Effect of miR-21 on the proliferation and osteogenic differentiation of human periodontal ligament stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(9): 569-574.
[2] XU Hongwei,HAN Bing. Research progress in mechanical strength enhancement methods of jaw tissue engineering scaffolds [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(9): 600-606.
[3] CHEN Songling,ZHU Shuangxi. The role of the membrane of the maxillary sinus in space osteogenesis under the sinus floor after elevation of the sinus floor [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(8): 477-486.
[4] QIN Qing,SONG Yang,LIU Jia,LI Qiang. Effects of casein kinase 2 interacting protein-1 on the osteogenic differentiation ability of human periodontal ligament stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 421-426.
[5] LIU Huimin,LI Xiangwei. Research progress of scaffolds for promoting the vascularization of regenerated dental pulp [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 200-204.
[6] YE Qingsong, HU Fengting, LUO Lihua, Maria Troulis. Research and application of stem cell-derived exosomes in regenerative medicine [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(1): 1-10.
[7] LIAO Chunhui,LI Mingfei,YE Jinmei,PENG Wei,CHEN Songling. The regulatory mechanisms of IGF1 in the osteogenic differentiation of canine MSMSCs via BMP2-Smad1/5 signaling pathway [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(1): 16-23.
[8] LIU Ying,YANG Jing,LI Yazhen,YAN Xiao,ZHANG Qiang,REN Dapeng,YANG Fang,YUAN Xiao,GUO Qingyuan. Effects of silencing the HIF-1α gene on the expression of BSP and osterix in rat BMMSCs under tension [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(5): 287-292.
[9] HU Huiting,YU Fenglin,ZHAO Yueping. Research progress on the factors influencing the biological characteristics of dental pulp stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(4): 268-272.
[10] XU Xiongcheng,ZHONG Quan,LUO Kai. Application of 3D printing technology in preparation of scaffolds for periodontal tissue regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(3): 189-193.
[11] HE Hongzhi,MA Dandan. Research progress on exosomes derived from dental pulp stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(10): 652-657.
[12] YIN Xiaoping,XIONG Huacui,CHEN Ke,HUANG Ying,XU Shuaimei. The effects of leptin on osteogenesis/odontogenic related gene expression of human apical papillary stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(1): 23-29.
[13] Qiaoli NIU, Yiming LI, Yanyan SONG, Chenxi LI, Jin ZHAO. Effects of different concentrations of MTA on the proliferation and differentiation of stem cells from the apical papilla [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 491-495.
[14] Jing ZHANG, Shuangxi ZHU, Qiong RONG, Wei PENG, Xiang LI, Songling CHEN. Role of miR-27a in the osteogenic differentiation of beagle maxillary sinus membrane stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 484-490.
[15] Xuening GU, Jiamiao QUAN, Yuqing GUO, Song LI. cAMP-responsive-element-binding protein promotes the differentiation of human stem cells from the apical papilla via inhibition of the TGF-β1 pathway [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 428-433.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!
This work is licensed under a Creative Commons Attribution 3.0 License.