Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (2): 73-80.doi: 10.12016/j.issn.2096-1456.2021.02.001

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Detection and significance of immune function in oral mucosa-associated diseases

WANG Anxun()   

  1. Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
  • Received:2020-02-09 Revised:2020-04-25 Online:2021-02-20 Published:2020-12-21
  • Contact: Anxun WANG E-mail:wang_anxun@aliyun.com
  • Supported by:
    grants from National Nature Science Foundation of China(NSFC81672659);Guangdong Basic and Applied Basic Research Foundation(2020A1515010291)

Abstract:

The evaluation of immune function plays an important role in the diagnosis, treatment and prognosis of many diseases. To date, immune function detection includes cellular immunity, humoral immunity, and inflammatory markers. In this paper, the application of immune function detection in the diagnosis, differential diagnosis and treatment monitoring of various diseases was discussed; then, the application value of immune function detection in the diagnosis and treatment of three common oral mucosa-related diseases, including recurrent aphthous ulcer (RAU), oral lichen planus (OLP), and oral squamous cell carcinoma (OSCC), were reviewed combined with the literature and our research. Our research found that RAU patients present abnormal humoral immune function and obvious inflammatory reactions, whereas OLP and OSCC patients present mild inflammatory reactions and more serious abnormal cellular and humoral immune function, so the combined detection of immune function has a certain guiding value for the diagnosis and treatment of these diseases. Moreover, in the future, it is necessary to carry out a study on large sample, multicenter and multiindex joint detection to better clarify the role of immune dysfunction in the pathogenesis of various diseases and its mechanism, to establish the corresponding diagnostic model and prognostic prediction model, to find more effective treatment methods.

Key words: recurrent aphthous ulcer, lichen planus, oral squamous cell carcinoma, oral mucosa, immunity, lymphocyte subsets, cellular immunity, humoral immunity, inflammation, biomarkers

CLC Number: 

  • R781.5
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