Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (2): 99-105.DOI: 10.12016/j.issn.2096-1456.2021.02.005

• Clinical Study • Previous Articles     Next Articles

Meta-analysis of the effect of platelet-rich fibrin in alveolar ridge preservation

DONG Jingbo(),LI Zhenzhen,LIU Chenxi,SHI Peikai()   

  1. Department of Oral and maxillofacial surgery, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University,Shijiazhuang 050017, China
  • Received:2020-08-31 Revised:2020-09-17 Online:2021-02-20 Published:2020-12-21
  • Contact: Peikai SHI
  • Supported by:
    grants from Hebei Provincial Government Subsidizes the Training of Excellent Clinical Medical Talents and Basic Research Projects(2017043639-2)



  1. 河北医科大学口腔医学院·口腔医院口腔颌面外科,河北省口腔医学重点实验室,河北省口腔疾病临床医学研究中心,河北 石家庄(050017)
  • 通讯作者: 石培凯
  • 作者简介:董静博,硕士研究生在读,Email:
  • 基金资助:


Objective To evaluate the effect of platelet-rich fibrin (PRF) on alveolar ridge preservation after tooth extraction. Methods Randomized controlled trials (RCTs) published before August 25, 2020 about the use of PRF after tooth extraction were searched through the PubMed, Embase, Cochrane Library, HowNet, Wanfang, CBM databases and clinical trial registration centers in China and the United States. Outcome indicators included in the studies included dry socket occurrence, alveolar bone resorption in the horizontal and vertical directions, and the percentage of new bone. Meta-analysis was conducted with Review Manager Version 5.3 software. Results A total of 706 studies were retrieved. After screening, 8 studies were analyzed quantitatively. Meta-analysis results showed that PRF could reduce the absorption of alveolar bone after tooth extraction, which reduced the horizontal bone mass (WMD=-0.71, 95% CI=-1.11 to -0.32, P < 0.05) and buccal (WMD=-1.38, 95% CI =-1.87 to -0.88, P < 0.05) and lingual sides (WMD=-0.49, 95% CI=-0.92 to -0.06, P < 0.05) and increased the percentage of new bone (SMD=1.24, 95% CI =0.25 to 2.23, P < 0.05). However, there was no significant difference in preventing the occurrence of dry socket (RD < 0.01, 95% CI=-0.05 to 0.04, P=0.95) and reducing bone absorption in the vertical direction of mesial (WMD=-0.11, 95% CI=-1.17 to 0.95, P=0.84) and distal (WMD=-0.66, 95% CI=-1.93 to 0.60, P=0.30) alveolar ridge after tooth extraction. Conclusion Using PRF alone after tooth extraction can effectively preserve bone mass in the horizontal direction of the alveolar ridge and the vertical direction of the buccal and lingual sides.

Key words: platelet-rich fibrin, platelet-concentrate, tooth socket, alveolar bone absorption, socket preservation, alveolar ridge preservation, randomized controlled trials, meta-analysis


目的 评价拔牙后使用富血小板纤维蛋白(platelet-rich fibrin,PRF)在位点保存中的效果。方法 检索Pubmed、Embase、Cochrane library、知网、万方、CBM数据库及中国、美国临床试验注册中心2020年8月25日前发表的有关拔牙后使用PRF的随机对照临床试验(randomized controlled trials,RCTs),纳入研究的结局指标包括干槽症、水平和垂直方向牙槽骨吸收、新生骨百分比,应用Review Manager 5.3版软件进行meta分析。结果 共检索到文献706篇,经筛选后纳入11篇研究,其中8篇定量分析,meta分析结果显示拔牙后使用PRF能减少牙槽骨的吸收,其中减少水平骨量(WMD=-0.71,95%CI=-1.11~-0.32,P < 0.05),颊侧垂直骨量(WMD=-1.38,95%CI =-1.87~-0.88,P < 0.05)、舌侧垂直骨量(WMD=-0.49,95% CI=-0.92~-0.06,P < 0.05) 的吸收,而且提高了新生骨百分比(SMD=1.24,95% CI=0.25~2.23,P < 0.05),但在预防术后干槽症发生(RD < 0.01,95%CI=-0.05~0.04,P=0.95)及减少牙槽窝近中(WMD=-0.11,95% CI =-1.17~0.95,P=0.84)、远中(WMD=-0.66,95% CI=-1.93~0.60,P=0.30) 垂直方向骨吸收上差异无统计学意义。结论 拔牙后单纯使用PRF,可有效保存牙槽嵴水平方向及颊舌侧垂直方向的骨量。

关键词: 富血小板纤维蛋白, 浓缩血小板, 牙槽窝, 牙槽骨吸收, 位点保存, 牙槽嵴保存, 临床随机对照试验, meta分析

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