Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (2): 119-123.DOI: 10.12016/j.issn.2096-1456.2021.02.009

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The relationship between Candida albicans infection and oral cancer

SHI Yangyang(),ZHOU Xuedong,CHENG Lei,REN Biao()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-07-07 Revised:2020-10-01 Online:2021-02-20 Published:2020-12-21
  • Contact: Biao REN
  • Supported by:
    grants from National Natural Science Foundation of China(81870778)


时洋洋[Author]) AND 1[Journal]) AND year[Order])" target="_blank">时洋洋(),周学东[Author]) AND 1[Journal]) AND year[Order])" target="_blank">周学东,程磊[Author]) AND 1[Journal]) AND year[Order])" target="_blank">程磊,任彪[Author]) AND 1[Journal]) AND year[Order])" target="_blank">任彪()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科,四川 成都(610041)
  • 通讯作者: 任彪
  • 作者简介:时洋洋,学士,Email:
  • 基金资助:


Oral cancer is one of the most common cancers that occur in the head and neck and can seriously affect the life span and living standard of oral cancer patients. Candida albicansC. albicans) is the most common opportunistic pathogenic fungus in the oral cavity, shows pathogenicity and easily causes Candida infection when the host′s immune function is low. Recent studies have shown that C. albicans infection is closely related to oral cancer. This paper reviews the epidemiology of C. albicans infection in oral cancer patients, the influence of C. albicans infection on the occurrence and development of oral cancer and research on its mechanism. Existing studies have shown an increased risk of C. albicans infection in oral cancer patients, while C. albicans infection may promote the occurrence and development of oral cancer through mechanisms such as damaging the oral epithelium; producing carcinogens, including nitrosamine and acetaldehyde; and inducing a chronic inflammatory response and T helper cell 17 immune response. However, these mechanisms are still relatively superficial and lack sufficient direct evidence. In the future, additional in-depth studies are still needed to further clarify the cancer-promoting mechanisms of C. albicans and provide new ideas for the prevention and treatment of oral cancer.

Key words: Candida albicans, Candida albicans, oral cancer, oral cancer, oral epithelial injury, oral epithelial injury, nitrosamines, nitrosamines, acetaldehyde, acetaldehyde, chronic inflammatory, chronic inflammatory, T helper cell 17 immune response, T helper cell 17 immune response



关键词: 白色念珠菌, 白色念珠菌, 口腔癌, 口腔癌, 口腔上皮损伤, 口腔上皮损伤, 亚硝胺, 亚硝胺, 乙醛, 乙醛, 慢性炎症, 慢性炎症, 辅助性T细胞17免疫反应, 辅助性T细胞17免疫反应

CLC Number: