Abstract:

Cyclophilin A (CypA) is the first foldable enzyme in human cells that has peptidyl proliferase-trans isomerase activity and has a strong proinflammatory effect. CD147 can act as the signal receptor of CypA. The interaction of the two through cell-surface heparin binding activates extracellular regulated protein kinases (ERK1/2) and nuclear factor kappa-B (NF-κB) signaling pathways in macrophages and increases the expression of MMPs and other inflammatory factors. The CypA/CD147 interaction regulates inflammation, promotes the inflammatory response and bone resorption and is involved in the pathological processes of a variety of systemic diseases. CypA and CD147 may take part in the chemotaxis of inflammatory cells, increase white blood cell infiltration in tissues, and increase CypA and CD147 expression in periodontitis gum tissue and gingival groove liquid with inflammation, prompting their interaction to promote the progression of periodontitis. However, the specific function of the signaling pathways in the periodontitis mechanism still requires further elucidation.

Key words: cyclophilin A, CD147, matrix metalloproteinase, cytokines, chemotaxis, immunological effect, periodontitis

摘要：

亲环蛋白A（cyclophilin A,CypA）是人类细胞中首个发现具有肽基脯氨酸顺反异构酶活性的折叠酶,具有强大的促炎作用;CD147可以作为CypA的信号受体;二者通过细胞表面肝素结合,相互作用后可启动巨噬细胞中细胞外调节蛋白激酶（extracellular regulated protein kinases,ERK1/2）和核因子κB（nuclear factor kappa-B,NF-κB）信号途径,增加基质金属蛋白酶（matrix metalloproteinase,MMPs）及其他炎症因子的表达。CypA/CD147的相互作用对炎症有调节作用,包括促进炎症反应和骨质吸收,并可参与多种全身疾病的病理过程。CypA和CD147可参与炎症细胞的趋化作用,增加炎症组织中白细胞的浸润,在牙周炎牙龈组织及龈沟液中的CypA及CD147表达随着炎症加重而增多,提示二者的相互作用促进牙周炎的进展,但该信号通路在牙周炎中的具体作用机制还有待进一步研究。

关键词: 亲环蛋白A, CD147, 基质金属蛋白酶, 细胞因子, 趋化作用, 免疫效应, 牙周炎