Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (3): 194-197.DOI: 10.12016/j.issn.2096-1456.2021.03.009

• Review Articles • Previous Articles     Next Articles

Research progress on the role of T helper cells 17 and interleukin 17 in oral mucosal diseases

WANG Ziying1(),CHEN Xiaotao2()   

  1. 1. Xinjiang Medical University School of Stomatology, Urumqi 830001, China
    2. Department of Stomatology, The People′s Hospital of the Xinjiang Uygur Autonomous Region, Urumuqi 830001, China
  • Received:2020-06-12 Revised:2020-07-29 Online:2021-03-20 Published:2021-01-12
  • Contact: Xiaotao CHEN
  • Supported by:
    National Natural Science Foundation of China(81660185)

辅助性T细胞17与白细胞介素17在口腔黏膜疾病中的研究进展

王紫莹1(),陈晓涛2()   

  1. 1.新疆医科大学口腔医学院,新疆维吾尔自治区 乌鲁木齐(832000)
    2.新疆维吾尔自治区人民医院口腔科,新疆维吾尔自治区 乌鲁木齐(832000)
  • 通讯作者: 陈晓涛
  • 作者简介:王紫莹,硕士研究生在读,Emai:463685076@qq.com
  • 基金资助:
    国家自然科学基金(81660185)

Abstract:

T helper 17 (Th17) cells are a new type of CD4+ T helper cell. They participate in the immune and inflammatory response by secreting specific interleukin-17 (IL-17). In oral mucosal diseases, oral lichen planus (OLP), recurrent aphthous ulcer (RAU) and Behcet′s disease (BD) are associated with Th17 cells and IL-17. There were 17 kinds of proteins in the saliva of patients with OLP that could upregulate the expression of Th17 cells and induce the secretion of IL-17. IL-17 can stimulate epithelial cells, endothelial cells and fibroblasts to produce a variety of cytokines, such as IL-6, IL-8, granulocyte macrophage colony-stimulating factor and cell adhesion molecule-1, leading to the production and aggravation of inflammation. Th17/Tc17 cell-targeted therapy can significantly improve the clinical symptoms of OLP patients′ mucosa and skin. IL-17 can stimulate oral keratinocytes through the IL-17RA or IL-17RE receptor and produce proinflammatory effects in RAU. Th17 cells in the peripheral blood of BD patients are significantly increased, while Treg cells are significantly decreased.

Key words: T helper cells 17, interleukin 17, oral mucosal disease, oral lichen planus, oral ulcer, recurrent aphthous ulcer, Behcet′s disease, proinflammatory effect

摘要:

辅助性T细胞17(T helper cells 17,Th17)细胞是一种新的CD4+T辅助细胞,其通过分泌特有的白细胞介素17(interleukin 17,IL-17)参与机体免疫及炎性反应。在口腔黏膜疾病中,口腔扁平苔藓(oral lichen planus,OLP)、复发性阿弗他溃疡(recurrent aphthous ulcer,RAU)、白塞病(Behcet′s disease,BD)的发病均与Th17细胞、IL-17相关。OLP患者唾液中有17种与OLP发生相关的、可上调Th17细胞的表达及诱导IL-17分泌的蛋白质;IL-17通过刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子,如IL-6、IL-8、粒细胞-巨噬细胞集落刺激因子及细胞黏附分子1,致使炎症的产生及加重;Th17/Tc17细胞的靶向治疗可使OLP患者黏膜和皮肤的临床症状得到明显改善。IL-17可通过IL-17RA或IL-17RE受体刺激口腔角质细胞,在RAU中产生促炎作用。BD患者外周血中Th17细胞明显增高,而Treg细胞显著降低。

关键词: 辅助性T细胞17, 白细胞介素17, 口腔黏膜疾病, 口腔扁平苔藓, 口腔溃疡, 复发性阿弗他溃疡, 白塞病, 促炎作用

CLC Number: