Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (4): 284-288.doi: 10.12016/j.issn.2096-1456.2021.04.011

• Review Articles • Previous Articles    

Research progress on the application of antibacterial titanium alloys in stomatology

FAN Dongyang1,2,3(),WANG Qiang4,ZHOU Yijun2,LI Siwen1,2,3,FENG Xu5,LIU Chunran2,CUI Jiasen2,SUN Hongchen2()   

  1. 1. Department of General Dentistry, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
    2. Department of Oral Pathology, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
    3. Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110002, China
    4. Department of Dental Materials, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
    5. Department of Orthodontics, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
  • Received:2020-07-08 Revised:2020-10-17 Online:2021-04-20 Published:2021-02-26
  • Contact: Hongchen SUN E-mail:1018692729@qq.com;hcsun@mail.jlu.edu.cn
  • Supported by:
    National Key Research and Development Program of China(2016YFC1102800);Science and Technology Project of Liaoning Province(2018225059)

Abstract:

Currently, titanium alloys are widely used in the field of stomatology; however, owing to long-term exposure to a complex microbial environment, dental plaques easily form on the surface of the materials, affecting the use efficiency and the service life of the materials. The antibacterial titanium alloy is a new kind of titanium alloy with antimicrobials added through surface modification or overall modification. Based on the location of antibacterial agents in titanium alloy materials, antibacterial titanium alloys can be divided into coating and alloy types. The antibacterial effect of coated antibacterial titanium alloy is good, but the disadvantage is that most of the coatings are not wear-resistant. The widely-used antibacterial agent of the alloy type is metal elements, which can be evenly distributed in the alloy, and the antibacterial properties are stable and long-lasting. Based on whether antibacterial agents can be released, antibacterial titanium alloys can be further divided into active antibacterial and passive antibacterial types. Active antibacterial type titanium alloys can release loaded antibacterial agents, and the antibacterial effect is more obvious, but the release duration of antibacterial agents is relatively short. Passive antibacterial titanium alloys exhibit an antibacterial effect by contact sterilization or inhibition of bacterial adhesion instead of releasing antibacterial agents. The antibacterial titanium alloy can inhibit the adhesion of bacteria on the surface of the material and prolong the service life of oral orthodontic appliances, implants and titanium plates. Moreover, the mechanical properties of the titanium alloy after antibacterial modification are not significantly affected, and the addition of antibacterial agents such as hydroxyapatite can increase the osteogenic function of the material. Therefore, the alloy has good application prospects in the fields of dental implant, orthodontic treatment and oral and maxillofacial surgery. However, most of the current studies on antibacterial titanium alloys are in vitro experiments, and their long-term clinical effects and antibacterial mechanisms are still unclear and need further study.

Key words: titanium alloy, biofilm, adhesion, antibacterial property, antibacterial modification, antimicrobial, controlled release, alloy, coating, hydroxyapatite, chitosan, copper ions, anionic

CLC Number: 

  • R78
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