Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (5): 322-327.doi: 10.12016/j.issn.2096-1456.2021.05.005

• Clinical Study • Previous Articles     Next Articles

Accuracy analysis of MRI in the depth of invasion assessment of tongue squamous cell carcinoma

LI Ming1(),NAN Xinrong2,YUAN Zhenying2,TANG Zhangui1   

  1. 1. Xiangya Stomatological Hospital, Central South University, Changsha 410000, China
    2. Department of Stomatology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2020-10-18 Revised:2020-12-01 Online:2021-05-20 Published:2021-03-08
  • Contact: Ming LI E-mail:limingq248@163.com
  • Supported by:
    National Natural Science Foundation of China(8167041124)

Abstract:

Objective To analyze the accuracy of the infiltrating depth of tongue squamous cell carcinoma measured by magnetic resonance imaging (MRI) using pathological sections under a light microscope to provide a clinical reference. Methods Seventy-three patients with tongue squamous cell carcinoma who visited the Department of Stomatology of the First Hospital of Shanxi Medical University and Xiangya Stomatological Hospital from January 2018 to September 2020 were selected. Preoperative MRI was performed to evaluate the infiltration depth of tongue squamous cell carcinoma, and intraoperative frozen pathological sections were used to confirm the infiltration depth of tongue squamous cell carcinoma measurement. Results The infiltration depth of tongue squamous cell carcinoma measured by T1-weighted imaging was 1.11 mm (95% CI=0.51-1.70; t=3.72; P < 0.001), and the correlation coefficient r was 0.95. The T2-weighted average overestimation was 2.17 mm (95% CI=1.32-3.02; t=5.10; P < 0.001), and the correlation coefficient was 0.92. The Bland-Altman plot showed good consistency between T1- and T2-weighted images and pathologic measurements. Conclusion The infiltration depth of tongue squamous cell carcinoma measured by MRI is more accurate, with an average overestimation of 1-2 mm compared with pathological measurements, and T1-weighted images are better than T2-weighted images.

Key words: squamous cell carcinoma, tongue squamous cell carcinoma, oral squamous cell carcinoma, oral cancer, tongue neoplasms, depth of invasion, magnetic resonance imaging, pathological examination

CLC Number: 

  • R78

Figure 1

Invasive depth of tongue squamous cell carcinoma measured by MRI a:coronal position measurement; and the normal mucosal wiring of the tumor closest to it was identified, and the distance between the line and deepest depth is the tumor depth of invasion; b: the transverse location measurement schematic diagram, and the measurement method is the same as in that figure la"

Figure 2

Schematic diagram measuring the pathological infiltration depth of tongue squamous cell carcinoma a-b: the yellow arrows represent the intersection point of the tumor and the closest basal membrane of normal mucosa on both sides under the microscope (HE, ×40); c: the yellow arrows represent the deepest point of tumor cell infiltration (HE, ×200); d: the yellow lines represent the depth of tongue squamous cell carcinoma infiltration (HE)"

Figure 3

BlandAltman map of the infiltration depth of tongue squamous cell carcinoma by T1- and T2-weighted imaging and pathologic measurements The solid line is the average difference, and the dotted line is the 95%LoA of the difference. The mean difference in the invasion depth between T1-weighted images and pathological measurements was 1.11 mm, and the mean difference between T2-weighted images and pathological measurements was 2.17 mm; DOI: depth of invasion"

Figure 4

Correlation between T1- and T2-weighted MRI and the depth of invasion measured by pathology The pearson correlation coefficient r between T1-weighted images and pathology was 0.95 (P < 0.001). The correlation coefficient r between T2-weighted imaging and pathology was 0.92 (P < 0.001); DOI: depth of invasion"

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