Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (5): 334-339.DOI: 10.12016/j.issn.2096-1456.2021.05.007

• Review Articles • Previous Articles     Next Articles

Research progress on the Hippo-YAP signaling pathway mediated osteoimmunology in modulating implant osseointegration

ZHOU Anqi1(),LIU Jiayi1,JIA Yinan1,XIANG Lin2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-06-07 Revised:2020-11-24 Online:2021-05-20 Published:2021-03-08
  • Contact: Lin XIANG
  • Supported by:
    the National Natural Science Foundation of China(81701007);Fundamental Research Funds for the Central Universities(2018SCUH0006);Research Funding from West China School/Hospital of Stomatology Sichuan University(RCDWJS2020-6);Basic and Applied Basic Research Projects of West China Hospital of Stomatology of Sichuan University(RD-02-201902)

Hippo-YAP信号轴介导骨免疫调节种植体骨结合的研究进展

周安琪1(),刘佳怡1,贾懿楠1,向琳2()   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院,四川 成都(610041)
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科,四川 成都(610041)
  • 通讯作者: 向琳
  • 作者简介:周安琪,本科,Email: zhouaq0225@163.com
  • 基金资助:
    国家自然科学基金项目(81701007);中央高校基本科研业务费专项资金(2018SCUH0006);四川大学华西口腔医学院(华西口腔医院)科研经费资助项目(RCDWJS2020-6);四川大学华西口腔医院基础与应用基础研究项目(RD-02-201902)

Abstract:

Ideal osseointegration is intimately related to favorable osteoimmune properties around dental implants. An increasing number of in vitro and in vivo studies have indicated that the Hippo-YAP signaling pathway is involved in this biological process. In this article, the implicated roles of Hippo-YAP the signaling axis in peri-implant osteoimmunology were summarized by reviewing relevant evolving literature. The discrepancy concerning the Hippo-YAP signaling regulatory effect on osteogenesis and polarization direction were analyzed as well as propose the potential mechanism, which may be caused by the maturation of osteogenesis-related cells and heterogeneity of macrophages. More attention should be given to the requirements of promoting osteogenesis and patterns of regulating the immune microenvironment by Hippo-YAP in future studies.

Key words: osseointegration, bone repair, Hippo-YAP signaling pathway, osteoimmunology, implants, osteogenesis, bone remodeling, macrophages

摘要:

理想的骨结合与种植体周围良好的骨免疫特性密切相关,越来越多的体内外研究发现Hippo-YAP信号通路参与了这一生物学进程。本文就Hippo-YAP信号轴介导的种植体周骨免疫效应作一综述。目前研究表明,Hippo-YAP信号轴可能通过调节成骨相关细胞的成骨分化和巨噬细胞的极化方向影响种植体周骨免疫微环境,从而在调控种植体骨结合进程中发挥作用。此外,笔者还对Hippo-YAP信号在调控成骨相关细胞成骨行为和巨噬细胞极化方向中的作用差异分别进行了分析,这种差异可能与成骨相关细胞成熟度和巨噬细胞的异质性等因素有关。未来的研究可以更关注Hippo-YAP促进成骨的条件和调控免疫微环境的内在规律。

关键词: 骨结合, 骨修复, Hippo-YAP信号轴, 骨免疫, 种植体, 成骨, 骨重建, 巨噬细胞

CLC Number: