Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (6): 417-421.DOI: 10.12016/j.issn.2096-1456.2021.06.010

• Review Articles • Previous Articles     Next Articles

Bleeding after tooth extraction in patients receiving anticoagulation/antiplatelet therapy

HUANG Jinxia(),SHI Haitao,PAN Jian()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-03-02 Revised:2020-12-09 Online:2021-06-20 Published:2021-04-12
  • Contact: Jian PAN
  • Supported by:
    grants from Sichuan Academic and Technical Leader Training Foundation(2017-A);Sichuan Cadres Health Care Project(川干研2019-901);Research and Develop Program, West China Hospital of Stomatology Sichuan University(LCYJ2019-1)



  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院口腔颌面外科,四川 成都(610041)
  • 通讯作者: 潘剑
  • 作者简介:黄金霞,医师,硕士研究生,Email:
  • 基金资助:


Tooth extraction in patients receiving anticoagulation/antiplatelet therapy is often considered contraindicated by many oral and maxillofacial surgeons because of a higher risk of postoperative bleeding. Multiple factors contribute to postoperative bleeding, but there is no consensus. Based on recent literature, this article reviews factors related to bleeding after tooth extraction in patients receiving anticoagulation/antiplatelet therapy. The literature review indicates that patients taking antiplatelet drugs have a lower postoperative bleeding risk than patients taking anticoagulant drugs. Prescription of anticoagulants together with non-steroidal anti-inflammatory drugs, selective serotonin inhibitors or serotonin-norepinephrine inhibitors increases the risk of bleeding, so does preoperative antibiotic use increase. In addition, systemic diseases such as diabetes, history of infection at the extraction site, and greater surgical trauma are associated with a higher risk of postoperative bleeding. At present, it is generally believed that it is safe and feasible to use different hemostatic measures after tooth extraction and to rationally apply different hemostatic measures after surgery. More prospective controlled trials are needed in the future to establish an assessment system for patients undergoing anticoagulation/antiplatelet therapy under different conditions during tooth extraction.

Key words: anticoagulants, antiplatelet drugs, nonsteroidal anti-inflammatory drugs, antidepressants, antibiotics, tooth extraction, postoperative hemorrhage, coagulation markers, international normalized ratio



关键词: 抗凝药物, 抗血小板药物, 非甾体类抗炎药, 抗抑郁药, 抗生素, 拔牙术, 术后出血, 凝血指标, 国际标准化比

CLC Number: