Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (7): 485-489.DOI: 10.12016/j.issn.2096-1456.2021.07.009

• Review Articles • Previous Articles     Next Articles

Research progress on the correlation between interleukin-18 and chronic periodontitis

SHAN Chao1,2(),WANG Tingting1,2,ZHAO Jin1,2,3()   

  1. 1. Xinjiang Medical University, Urumqi 830011, China
    2. Department of Endodontics, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi 830054, China
    3. Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi 830011, China
  • Received:2020-07-19 Revised:2020-10-16 Online:2021-07-20 Published:2021-04-19
  • Contact: Jin ZHAO
  • Supported by:
    National Natural Science Foundation of China(81760194);Graduate Student Scientific Research Innovation Project of Autonomous region(XJ2019G180);Key Research and Development Projects of Autonomous Region(2016B03049-1)



  1. 1.新疆医科大学,新疆维吾尔自治区 乌鲁木齐(830011)
    2.新疆医科大学第一附属医院(附属口腔医院)牙体牙髓科,新疆维吾尔自治区 乌鲁木齐(830054)
    3.新疆维吾尔自治区口腔医学研究所,新疆维吾尔自治区 乌鲁木齐(830011)
  • 通讯作者: 赵今
  • 作者简介:单超,硕士研究生,Email:
  • 基金资助:


Chronic periodontitis is an infectious disease caused by plaque as the initiating factor. Clinically, it manifests as irreversible loss of hard tissue, leading to the destruction of surrounding periodontal tissue, including the deep periodontal pocket, loss of attachment, and finally, tooth loss. Interleukin-18 (IL-18) can promote inflammation and regulate immune function and plays an important role in mediating the host immune response and inflammatory response. An increase in IL-18 in vivo can induce the production of interferon and inflammatory factors, such as interleukin, tumor necrosis factor and matrix metalloproteinase, thus mediating the dual reaction of immunity and inflammation. These inflammatory factors are involved in the occurrence and development of chronic periodontitis. Many clinical studies have shown that the levels of IL-18 in serum, saliva, gingival crevicular fluid and gingival tissue samples of patients with chronic periodontitis may be positively correlated with the severity of periodontitis; however, as a candidate gene, IL-18 is involved in the susceptibility polymorphism of periodontitis. Understanding how to quantify the level of IL-18 in clinical studies and apply it to diagnostic tools and new sites identified by new methods (genome-wide association studies and omics research) will also deepen our understanding of the pathogenesis of IL-18 in chronic periodontitis and provide new ideas for future precision medicine and the formulation of personalized programs. In this paper, the structure, biological function and association between IL-18 and periodontitis are reviewed.

Key words: chronic periodontitis, interleukin-18, interferon-γ, adaptive immunity, inflammation, transcriptional level, gene polymorphism



关键词: 慢性牙周炎, 白细胞介素-18, 干扰素-γ, 适应性免疫, 炎症反应, 转录水平, 基因多态性

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