Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (10): 711-715.DOI: 10.12016/j.issn.2096-1456.2021.10.011

• Review Articles • Previous Articles     Next Articles

Research progress on the reconstruction of mandibular defects in adolescents

BIN Zhiwen1(),WANG Fang2,HOU Jinsong2()   

  1. 1. Department of Stomatology, Guilin Second People’s Hospital, Gunlin 541001, China
    2. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China
  • Received:2021-02-23 Revised:2021-04-20 Online:2021-10-20 Published:2021-06-23
  • Contact: Jinsong HOU
  • Supported by:
    National Natural Science Foundation of China(81874128)



  1. 1.广西桂林市第二人民医院口腔科,广西壮族自治区 桂林(541001)
    2.中山大学光华口腔医学院·附属口腔医院口腔颌面外科,广东 广州(510055)
  • 通讯作者: 侯劲松
  • 作者简介:宾志文,副教授,硕士,Emal:
  • 基金资助:


Mandibular defects in adolescents are mostly caused by surgical resection of benign and malignant tumors, trauma and jaw inflammation. The reconstruction of mandibular defects in adolescents is challenging. In addition to solving the problem of jaw reconstruction in adults, some clinical factors, including the influence of surgery on the growth of donor and recipient areas, the long-term effects of reconstruction, and the outcome of bone grafts, must also be considered. At present, the main reconstructive methods include autogenous bone grafts and distraction osteogenesis. Autogenous bone grafts are still the gold standard due to their long-term effects. Favorable growth potential after repair was shown in adolescent cases of mandibular reconstruction with fibula flap. Normal occlusion was restored, and a long-term stable effect was achieved in cases of condylar reconstruction with costal cartilage. The safety and clinical effects of distraction osteogenesis have been confirmed, but the long-term effects of large-scale mandibular defects are still uncertain. In addition, other tissue engineering techniques also have good application prospects for the repair and reconstruction of adolescent mandible defects, but more in-depth basic research and more extensive clinical trials should be performed to verify the efficacy.

Key words: adolescent, mandibular defect, mandibular reconstruction, oral and maxillofacial, vascularized free tissue flap, bone graft, distraction osteogenesis, bone tissue engineering



关键词: 青少年, 下颌骨缺损, 下颌骨重建, 口腔颌面, 血管化游离组织瓣, 骨移植, 牵张成骨, 骨组织工程

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