Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (11): 771-775.doi: 10.12016/j.issn.2096-1456.2021.11.008

• Review Articles • Previous Articles     Next Articles

Research progress in the treatment of oral submucous fibrosis with traditional Chinese medicine and Western medicine

XIAO Ting(),TANG Zhangui()   

  1. Department of Oral and Maxillofacial Surgery, Xianya Stomatology Hospital, Xiangya School of Stomatology, Central South University, Changsha 410078, China
  • Received:2021-03-10 Revised:2021-03-20 Online:2021-11-20 Published:2021-07-20
  • Contact: Zhangui TANG E-mail:1341096929@qq.com;tangzhangui@aliyun.com
  • Supported by:
    National Natural Science Foundation of China(81671003)

Abstract:

Oral submucous fibrosis is a chronic, occult and progressive potentially malignant disease that seriously affects the oral function and quality of life of patients. The oral burning sensation and limitation of mouth opening are the main reasons for patients to see a doctor. At present, the main treatment for oral submucosal fibrosis is still drug therapy. To provide ideas and references for the clinical treatment of oral submucosal fibrosis, this article reviews the mechanism, therapeutic effect and characteristics of common Chinese and Western medicine in the treatment of oral submucosal fibrosis. The results of the literature review show that salvia miltiorrhiza, aloe, lycopene, curcumin and other traditional Chinese medicine and Western medicine are effective in the treatment of oral submucosal fibrosis; in addition, Taohong Siwu Decoction combined with Western medicine and other combinations of traditional Chinese and Western medicine are effective and reduce side effects, and clinicians can choose appropriate drugs according to the patient’s main symptoms and general condition. In the future, researchers can study more combinations of traditional Chinese and Western medicine to treat oral submucosal fibrosis.

Key words: oral submucous fibrosis, potentially malignant disease, burning sensation, limitation of mouth opening, treatment, traditional Chinese medicine, salvia miltiorrhiza, Western medicine, triamcinolone acetonide, combination of traditional Chinese and Western medicine

CLC Number: 

  • R78
[1] Peng Q, Li HY, Chen J, et al. Oral submucous fibrosis in Asian countries[J]. J Oral Pathol Med, 2020, 49(4):294-304. doi: 10.1111/jop.12924.
doi: 10.1111/jop.v49.4
[2] Shih YH, Wang TH, Shieh TM, et al. Oral submucous fibrosis: a review on etiopathogenesis, diagnosis, and therapy[J]. Int J Mol Sci, 2019, 20(12):22. doi: 10.3390/ijms20122940.
doi: 10.3390/ijms20010022
[3] Zheng S, Deng Z, Chen F, et al. Synergistic antioxidant effects of petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: role of Akt/Nrf2 pathway[J]. J Food Sci, 2020, 85(6):1752-1763. doi: 10.1111/1750-3841.15153.
doi: 10.1111/jfds.v85.6
[4] Johny J, Bhagvandas S, Mohan S, et al. Comparison of efficacy of lycopene and lycopene-hyaluronidase combination in the treatment of oral submucous fibrosis[J]. J Pharm Bioallied Sci, 2019, 11(6):S260-S264. doi: 10.4103/JPBS.JPBS_6_19.
[5] Gupta N, Kalaskar A, Kalaskar R. Efficacy of lycopene in management of oral submucous fibrosis-a systematic review and meta-analysis[J]. J Oral Biol Craniofac Res, 2020, 10(4):690-697. doi: 10.1016/j.jobcr.2020.09.004.
doi: 10.1016/j.jobcr.2020.09.004
[6] Gupta S, Ghosh S, Gupta S, et al. Effect of curcumin on the expression of p53, transforming growth factor-beta, and inducible nitric oxide synthase in oral submucous fibrosis: a pilot study[J]. J Investig Clin Dent, 2017, 8(4):e12252. doi: 10.1111/jicd.12252.
doi: 10.1111/jicd.2017.8.issue-4
[7] Chen W, Tuladhar A, Rolle S, et al. Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1[J]. Toxicol Appl Pharmacol, 2017, 329:58-66. doi: 10.1016/j.taap.2017.05.027.
doi: 10.1016/j.taap.2017.05.027
[8] Piyush P, Mahajan A, Singh K, et al. Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: a randomized controlled trial[J]. Oral Dis, 2019, 25(1):73-79. doi: 10.1111/odi.12947.
doi: 10.1111/odi.2019.25.issue-1
[9] Rai A, Kaur M, Gombra V, et al. Comparative evaluation of curcumin and antioxidants in the management of oral submucous fibrosis[J]. J Investig Clin Dent, 2019, 10(4):e12464. doi: 10.1111/jicd.12464.
[10] Liu J, Chen F, Wei Z, et al. Evaluating the efficacy of pentoxifylline in the treatment of oral submucous fibrosis: a meta-analysis[J]. Oral Dis, 2018, 24(5):706-716. doi: 10.1111/odi.12715.
doi: 10.1111/odi.12715 pmid: 28737007
[11] Sadaksharam J, Mahalingam S. Evaluation of oral pentoxifylline in the management of oral submucous fibrosis - an ultrasonographic study[J]. Contemp Clin Dent, 2017, 8(2):200-204. doi: 10.4103/ccd.ccd_1192_16.
doi: 10.4103/ccd.ccd_1192_16
[12] Bhadage CJ, Umarji HR, Shah K, et al. Vasodilator isoxsuprine alleviates symptoms of oral submucous fibrosis[J]. Clin Oral Investig, 2013, 17(5):1375-1382. doi: 10.1007/s00784-012-0824-z.
doi: 10.1007/s00784-012-0824-z
[13] Singh U. Efficacy and safety of intralesional Xantinol Nicotinate in the treatment of various stages of oral submucous fibrosis[J]. J Clin Diagn Res, 2016, 10(10):ZC34-ZC37. doi: 10.7860/jcdr/2016/20138.8639.
[14] Ehrchen JM, Roth J, Barczyk-Kahlert K. More than suppression: glucocorticoid action on monocytes and macrophages[J]. Front Immunol, 2019, 10:2028. doi: 10.3389/fimmu.2019.02028.
doi: 10.3389/fimmu.2019.02028 pmid: 31507614
[15] Desai VC, Shirsand SB, Malpani A, et al. Evaluation of mucoadhesive dexamethasone sodium phosphate gel in the treatment of arecoline-induced oral submucous fibrosis in wister albino rats: a cross-sectional study[J]. Indian J Dent Res, 2020, 31(5):685-693. doi: 10.4103/ijdr.IJDR_685_19.
doi: 10.4103/ijdr.IJDR_685_19
[16] Mostafa MG, Khan JA, Ahmed S, et al. Comparison between efficacy of combined use of hyaluronidise and triamcinolone versus hyaluronidise, triamcinolone acetonide and oral colchicine in the treatment of oral submucous fibrosis[J]. Mymensingh Med J, 2021, 30(1):79-84.
[17] Warnakulasuriya S, Kerr AR. Oral submucous fibrosis: a review of the current management and possible directions for novel therapies[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016, 122(2):232-241. doi: 10.1016/j.oooo.2016.02.020.
doi: 10.1016/j.oooo.2016.02.020
[18] More CB, Jatti Patil D, Rao NR. Medicinal management of oral submucous fibrosis in the past decade- a systematic review[J]. J Oral Biol Craniofac Res, 2020, 10(4):552-568. doi: 10.1016/j.jobcr.2020.08.004.
doi: 10.1016/j.jobcr.2020.08.004
[19] Arakeri G, Rai KK, Boraks G, et al. Current protocols in the management of oral submucous fibrosis: an update[J]. J Oral Pathol Med, 2017, 46(6):418-423. doi: 10.1111/jop.12583.
doi: 10.1111/jop.2017.46.issue-6
[20] Panigrahi R, Maheshwari A. A prospective, randomized double blind study comparing intralesional triamcinolone acetonide and hyaluronidase combination versus triamcinolone acetonide alone in the treatment of oral submucosal fibrosis[J]. J Pharm Biomed Sci, 2014, 4(4):365-370.
[21] Sachdev PK, Freeland-Graves J, Beretvas SN, et al. Zinc, copper, and iron in oral submucous fibrosis: a meta-analysis[J]. Int J Dent, 2018, 2018. doi: 10.1155/2018/3472087.
[22] Maher R, Aga P, Johnson NW, et al. Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan[J]. Nutr Cancer, 1997, 27(1):41-47. doi: 10.1080/01635589709514499.
pmid: 8970180
[23] Wu C, Chen W, Ding H, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regionsin vivo andin vitro[J]. Life Sci, 2019, 239:116881. doi: 10.1016/j.lfs.2019.116881.
doi: 10.1016/j.lfs.2019.116881
[24] 翦新春, 郑廉, 朱蓉, 等. 曲安奈德和丹参酮注射液治疗口腔黏膜下纤维化的效果评价[J]. 中华口腔医学杂志, 2017, 52(1):16-21. doi: 10.3760/cma.j.issn.1002-0098.2017.01.004.
Jian XC, Zheng L, Zhu R, et al. Clinical effectiveness of salvianolic acid B and triamcinolone acetonide in treatment of oral submucous fibrosis[J]. Chin J Stomatol, 2017, 52(1):16-21. doi: 10.3760/cma.j.issn.1002-0098.2017.01.004.
[25] Xie H, Guo JC, Tan BY, et al. Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis a meta-analysis of randomized controlled trials[J]. Medicine, 2019, 98(27):7. doi: 10.1097/md.0000000000016339.
[26] Singh V, Agrawal U, Humtsoe EL, et al. Use of aloe vera and turmeric paste as a supplementary medicine in oral submucosal fibrosis: a pilot study[J]. Indian J Otolaryngol Head Neck Surg, 2019, 71:883-886. doi: 10.1007/s12070-019-01599-w.
doi: 10.1007/s12070-019-01599-w
[27] Anuradha A, Patil B, Asha VR. Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis-a clinical study[J]. J Oral Pathol Med, 2017, 46(1):50-55. doi: 10.1111/jop.12463.
doi: 10.1111/jop.12463 pmid: 27314762
[28] Rajbhoj AN, Kulkarni TM, Shete A, et al. A Comparative study to evaluate efficacy of curcumin and aloe Vera gel along with oral physiotherapy in the management of oral submucous fibrosis: a randomized clinical trial[J]. Asian Pac J Cancer Prev, 2021, 22(S1):107-112. doi: 10.31557/apjcp.2021.22.S1.107.
doi: 10.31557/APJCP.2021.22.S1.107
[29] Sarkar P, Stefi RV, Pasupuleti M, et al. Antioxidant molecular mechanism of adenosyl homocysteinase from cyanobacteria and its wound healing process in fibroblast cells[J]. Mol Biol Rep, 2020, 47(3):1821-1834. doi: 10.1007/s11033-020-05276-y.
doi: 10.1007/s11033-020-05276-y
[30] Shetty P, Shenai P, Chatra L, et al. Efficacy of spirulina as an antioxidant adjuvant to corticosteroid injection in management of oral submucous fibrosis[J]. Indian J Dent Res, 2013, 24(3):347-350. doi: 10.4103/0970-9290.118001.
doi: 10.4103/0970-9290.118001
[31] Yuan G, Han A, Wu J, et al. Bao Yuan decoction and Tao Hong Si Wu decoction improve lung structural remodeling in a rat model of myocardial infarction: possible involvement of suppression of inflammation and fibrosis and regulation of the TGF-β1/Smad3 and NF-κB pathways[J]. Biosci Trends, 2018, 12(5):491-501. doi: 10.5582/bst.2018.01242.
doi: 10.5582/bst.2018.01242
[32] 孙燕. 中西医联合治疗口腔黏膜下纤维化的疗效[J]. 全科口腔医学电子杂志, 2016, 3(9):44-45. doi: 10.16269/j.cnki.cn11-9337/r.2016.09.028.
Sun Y. Efficacy of combination of traditional Chinese and western medicine in the treatment of oral submucosal fibrosis[J]. Elect J General Stomatol, 2016, 3(9):44-45. doi: 10.16269/j.cnki.cn11-9337/r.2016.09.028.
[33] 王景博, 韦春珠, 潘茂华, 等. 活血化瘀方剂对重型颅脑损伤大鼠Wnt/β-连环蛋白信号通路表达的影响[J]. 中华危重病急救医学, 2020, 32(9):1101-1106. doi: 10.3760/cma.j.cn121430-20200615-00470.
Wang JB, Wei CZ, Pan MH, et al. Effect of Huoxue Huayu decoction on Wnt/β-catenin signal pathway expression in rats with severe traumatic brain injury[J]. Chin Crit Care Med, 2020, 32(9):1101-1106. doi: 10.3760/cma.j.cn121430-20200615-00470.
[34] 李元聪. 活血化瘀解毒法治疗口腔黏膜下纤维化60例[J]. 中医药导报, 2012, 18(3):86-87. doi: 10.13862/j.cnki.cn43-1446/r.03.043.
Li YC. The method of promoting blood circulation, removing blood stasis and detoxification was used to treat 60 cases of oral submucosal fibrosis[J]. Guid J Tradit Chin Med Pharm, 2012, 18(3):86-87. doi: 10.13862/j.cnki.cn43-1446/r.03.043.
[35] 刘一平. 中药内服和局部封闭治疗口腔黏膜下纤维变性46例疗效观察[J]. 新中医, 2006, 38(6):54-55. doi: 10.13457/j.cnki.jncm.2006.06.029.
Liu YP. Oral administration of traditional Chinese medicine and local blocking in the treatment of oral submucosal fibrosis: a clinical observation of 46 cases[J]. J New Chin Med, 2006, 38(6):54-55. doi: 10.13457/j.cnki.jncm.2006.06.029.
[36] 蔡鑫嘉, 黄俊辉, 姚志刚, 等. 丹参联合曲安奈德局部注射治疗口腔黏膜下纤维性变的meta分析[J]. 口腔疾病防治, 2018, 26(6):374-378. doi: 10.12016/j.issn.2096-1456.2018.06.007.
Cai XJ, Huang JH, Yao ZG, et al. Treatment of oral submucous fibrosis with local injection of salvia miltiorrhiza combined with triamcinolone ace tonide: a meta analysis[J]. J Prev Treat Stom Dis, 2018, 26(6):374-378. doi: 10.12016/j.issn.2096-1456.2018.06.007.
[37] Alam S, Ali I, Giri KY, et al. Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013, 116(6):717-724. doi: 10.1016/j.oooo.2013.08.003.
doi: 10.1016/j.oooo.2013.08.003
[1] CHEN Jing,CHEN Wenchuan. Research progress on tetrabutylammonium dihydrogen trifluoride as a substitute for hydrofluoric acid used for porcelain surface treatment [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(9): 629-633.
[2] LIU Li,ZHOU Yan,ZHANG Daling,WANG Yuanyuan. Two methods of treatment for skeletal Class Ⅲ malocclusion on airway changes before and after clinical research [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(8): 541-547.
[3] ZHANG Ying,HU Dandan,HUANG Haoning,LUO Xiaoping. Effect of different treatments of highly translucent zirconia on the bonding strength between zirconia and veneering porcelain [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 456-461.
[4] LAI Zhanwen,HU Ziyang,PAN Xiao,HAO Yanqing,LIN Zitong. Evaluation of temporomandibular joint space and condylar morphology in patients with anterior open-bite based on cone-beam CT [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 468-473.
[5] ZHANG Weilong,WU Wanqi,LIAO Shanhua,ZOU Junbin,ZHAN Xuzheng,LIN Jie. Fabrication of guide and removal of fiber post by tetrahedron positioning technology at the chair side: a case report and literature review [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 479-484.
[6] WANG Anxun. Diagnosis and treatment of benign condylar hyperplasia [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(6): 361-367.
[7] YAN Xingquan,NAN Xinrong,ZHANG Zejun,ZHANG Qi. Outcomes of surgical treatment of 29 patients with stages Ⅱ-Ⅲ bisphosphonate-related osteonecrosis of the jaw [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(6): 395-399.
[8] JIAN Xinchun,GAO Xing. Etiology, pathogenesis, diagnosis and treatment of oral submucous fibrosis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(4): 217-225.
[9] WANG Min,JIANG Nan,ZHU Songsong. A novel biomimetic micro/nano hierarchical interface of titanium enhances adhesion, proliferation and osteogenic differentiation of bone marrow mesenchymal cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(4): 226-233.
[10] DENG Yujie,YANG Xiaobin,CHEN Hao,LAI Jinhuan,ZHOU Miao. 1 429 cases treated with nitrous oxide inhalation sedation in dental clinic: a retrospective study [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(4): 249-253.
[11] WANG Chenwei,SUN Fangfang,YANG Chuncheng,DING Ling,CHEN Xi,ZHANG Jiaqi,WU Guofeng. Effects of concentrated sulfuric acid etching durations on the shear bond strength between polyether-ketone-ketone and dentin [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(3): 151-156.
[12] CHEN Zece,LONG Qian,GUAN Xiaoyan,LIU Jianguo. Research progress on microRNA-21 in regulating osteoclast and osteogenic differentiation in orthodontic treatment [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(3): 211-216.
[13] CHEN Shuang,XUE Xin,JIN Xing′ai,LIU Yingqun. Effect of dentin surface treatments on the bond strength of resin-modified glass ionomer cement [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(2): 130-134.
[14] ZHENG Jiawei,ZHAO Zeliang. Progress in evidence-based research on the clinical treatment of infantile hemangioma and vascular malformations [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(11): 721-732.
[15] WANG Tianqi,DU Qing,XIE Weili. Preparation and antibacterial properties of a copper-niobium coating on a titanium surface by a microarc oxidation-microwave hydrothermal method [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(11): 733-739.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. journal1, 2016, 24(1): 58 -60 .
[2] Juan LI,Ting HUANG,Wen XUE,Hai-yan LI. Clinical efficacy of basic periodontal therapy combined with local medication for erosive oral lichen planus[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(3): 162 -165 .
[3] Ming CHEN,Xi CHEN,Zhen-ting ZHANG. The precision comparison of the denture occlusal plane preparation by the occlusal plane plate between experienced and newly-graduated dentists[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(3): 173 -176 .
[4] Zhong-juan TAN,Yue-ping ZHAO,Yuan-yuan LUO. The research progress of dental pulp regeneration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(6): 374 -377 .
[5] Lan LIAO, Lijun ZENG. Updated research on digitalization in aesthetic restoration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 409 -414 .
[6] Yan-mei DONG. Causes and management of post-treatment apical periodontitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(10): 561 -566 .
[7] LI Chun,LI Yan-hong,LIU Juan. Application of probiotics for dental caries prevention in children[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(9): 558 -560 .
[8] Mingyu SUN, Hanjiang WU. Research progresses in occult lymph node metastasis of oral squamous cancer[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(1): 61 -65 .
[9] Qian-qian HAN,Zhao LIU,Li JIANG,Hui-yi TANG,Xiao-na LI. Effects of LMK-235 on osteoblast/odontoblast differentiation in hPDLCs[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(7): 390 -394 .
[10] Nu MI,Ying GUO,Xiao-yu YANG. Clinical evaluation of anterior teeth aesthetic restoration with thin porcelain laminate veneer[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(10): 589 -593 .
This work is licensed under a Creative Commons Attribution 3.0 License.