Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (11): 787-792.doi: 10.12016/j.issn.2096-1456.2021.11.011

• Review Articles • Previous Articles    

Research progress on the regulatory mechanism of estrogen in periodontal ligament cells repair and the reconstruction of periodontal tissue

LI Qi1(),WANG He2,HUANG Zijun1,HAN Qianqian3()   

  1. 1. Stomatological College of Zhaoqing Medical College, National Application Technology Collaborative Innovation Center of Primary Medical Service, Zhaoqing 526020, China
    2. Department of Endodontics Periodontal, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    3. Department of Periodontal, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
  • Received:2021-03-17 Revised:2021-04-03 Online:2021-11-20 Published:2021-07-20
  • Contact: Qianqian HAN E-mail:Licy13@163.com;hanqianqian04@163.com
  • Supported by:
    National Natural Science Foundation of China(82000994);Guangdong Medical Research Foundation(A2018066)

Abstract:

Periodontium regeneration and repair is a controversial and difficult point in the treatment of periodontosis. The proliferation, differentiation, migration and adhesion of periodontal ligament cells and the dynamic relationship between periodontal ligament cells and their extracellular matrix proteins are the basis of periodontium morphological reconstruction, functional maintenance and tissue repair. This article reviews the mechanism of estrogen-regulated periodontal membrane fine repair and periodontal tissue reconstruction to provide the basis for follow-up research on the treatment of periodontitis and the promotion of periodontal tissue repair and reconstruction by exogenous estrogen-mediated periodontal membranes. Under the regulation of certain concentrations of estrogen, the proliferation and differentiation ability of periodontal ligament stem cells (PDLSCs) and bone mesenchymal stem cells (BMSCs) to other periodontal ligament cells were enhanced. At the same time, PDLSCs, BMSCs, human periodontal ligament fibroblasts (HPLFSs), osteoblasts and cementoblasts synthesized and secreted collagen I (COLI), osteopontin (OPN), bone sialoprotein (BSP) and osteocalcin (OCN) into the extracellular matrix. They interact with fibronectin (FN) and cementum attachment protein (CAP) in the extracellular matrix to form a variety of chain complexes and regulate each other, thus promoting the growth, migration, adhesion and fibrosis of periodontal ligament cells, repairing the collagen fiber skeleton of the periodontal ligament and adhering the two ends to the new cementum and the inherent alveolar bone.

Key words: estrogen, periodontal ligament stem cells, periodontal ligament fibroblasts, cementoblasts, osteoblasts, osteoclasts, bone mesenchymal stem cells, collagen I, osteopontin, bone sialoprotein, osteocalcin

CLC Number: 

  • R781.4

Figure 1

Mechanistic model of the periodontal ligament cells and extracellular matrix proteins in periodontal tissue repair and reconstruction under estrogen regulation BMSCs: bone mesenchymal stem cells; PDLSCs: periodontal ligament stem cells; HPLFs: human periodontal ligament fibroblasts; OCN: osteocalcin; BSP: bone sialoprotein; OPN: osteopontin; COLI: collagen I; FN: fibronectin; CAP: cementum attachment protein"

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