Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (12): 820-827.DOI: 10.12016/j.issn.2096-1456.2021.12.004

• Basic Study • Previous Articles     Next Articles

Correlation between HLA-DQB1 and HLA-DRB1 gene polymorphisms and caries: a systematic review and Meta-analysis

CHEN Yue1(),WU Zeyu2,3,MO Yanli1,JING Yinghao1,LIU Yishan1,3()   

  1. 1. Department of Pediatric Dentistry and Preventive Dentistry, The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University), Urumqi 830054, China
    2. Department of Cariology and Endodontics, the First Affiliated Hospital of Xinjiang Medical University (the Affiliated Stomatology Hospital of Xinjiang Medical University), Urumqi 830054 China
    3. Stomatology Disease Institute of Xinjiang Uyghur Autonomous Region, Urumqi 830054, China
  • Received:2021-04-08 Revised:2021-05-19 Online:2021-12-20 Published:2021-08-17
  • Contact: Yishan LIU
  • Supported by:
    National Natural Science Foundation of China(81560178)



  1. 1.新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科,新疆维吾尔自治区 乌鲁木齐(830054)
    2.新疆医科大学第一附属医院(附属口腔医院)牙体牙髓病科,新疆维吾尔自治区 乌鲁木齐(830054)
    3.新疆维吾尔自治区口腔医学研究所,新疆维吾尔自治区 乌鲁木齐(830054)
  • 通讯作者: 刘奕杉
  • 作者简介:陈越,医师,硕士研究生,Email:dentist-
  • 基金资助:


Objective Systematic evaluation of the correlation of HLA-DQB1 and HLA-DRB1 allele polymorphisms with caries, to provide reference for caries prevention and treatment. Methods Relevant literature published before December 2020 was searched in the Cochrane Library, PubMed, Embase, Web of Science, Scopus, CNKI, Wanfang, VIP, and CBM databases. Meta-analysis was performed using the R4.0.2 software to test for heterogeneity and evaluate the publication bias. Results In total,10 case-control studies were included with 564 people in the case group and 676 people in the control group. The results of the Meta-analysis show that: ① HLA-DQB1*02 (OR=0.52, 95%CI=0.29-0.93, P < 0.05) and HLA-DRB1*09 (OR=0.34, 95%CI=0.21-0.58, P < 0.05) are protective factors of dental caries; ② HLA-DRB1*13 (OR=2.96, 95%CI=2.03-4.33, P < 0.05) and HLA-DRB1*14 (OR=1.95, 95%CI=1.26-3.02, P < 0.05) alleles are risk factors for the development of dental caries. The results of the subgroup analysis are: HLA-DRB1*07 is a caries susceptibility factor in the Chinese population (OR=0.48, 95% CI=0.24-0.97, P < 0.05), while it is not statistically significant in the Brazilian and Turkish populations; HLA-DRB1*11 is a caries protective factor in the saliva group (OR=2.26, 95% CI=1.46-3.52, P < 0.05). 3.52, P < 0.001), while it is a caries susceptibility factor in the blood group (OR=0.09, 95% CI=0.12-0.34, P < 0.001). Conclusion HLA-DRB1*13 and HLA-DRB1*14 alleles are caries susceptibility genes, and HLA-DQB1*02 and HLA-DRB1*09 have protective effects on the caries development. HLA-DRB1*07 is a caries susceptibility gene in the Chinese population; HLA-DRB1*11 is a caries protective gene in the saliva group. Due to the limited sample size and quality of the included studies, more high-quality studies will be included later for verification.

Key words: dental caries, genetic susceptibility, gene polymorphism, HLA-DQB1, HLA-DRB1, systematic review, Meta-analysis, case-control study


目的 系统评价HLA-DQB1和HLA-DRB1等位基因多态性与龋病的相关性,为龋病防治提供参考。方法 在Cochrane Library、PubMed、Embase、Web of Science、Scopus、知网、万方、维普、中国生物医学文献数据库中检索2020年12月之前发表的相关文献。采用R4.0.2软件进行Meta分析,进行异质性检验,并评价发表偏倚。结果 共纳入10篇病例对照研究,病例组564例,对照组676例。Meta分析结果显示:① HLA-DQB1*02(OR=0.52,95%CI=0.29~0.93,P < 0.05)和HLA-DRB1*09(OR=0.34,95%CI=0.21~0.58,P < 0.05)等位基因是龋保护因素;② HLA-DRB1*13(OR=2.96,95%CI=2.03~4.33,P < 0.05)和HLA-DRB1*14(OR=1.95,95%CI=1.26~3.02,P < 0.05)等位基因是龋易感因素。亚组分析结果: HLA-DRB1*07在中国人群中是龋易感因素(OR=0.48,95%CI=0.24~0.97,P < 0.05),而在巴西人群、土耳其人群中均无统计学意义; HLA-DRB1*11在唾液组中为龋保护因素(OR=2.26,95%CI=1.46~3.52,P < 0.001),而在血液组中为龋易感因素(OR=0.09,95%CI=0.12~0.34,P < 0.001)。结论 HLA-DRB1*13和HLA-DRB1*14等位基因是龋易感因素,HLA-DQB1*02和HLA-DRB1*09是龋保护因素。HLA-DRB1*07在中国人群是龋易感因素;HLA-DRB1*11在唾液组中为龋保护因素。因纳入研究样本量及质量有限,待后期纳入更多高质量研究予以验证。

关键词: 龋病, 遗传易感性, 基因多态性, HLA-DQB1, HLA-DRB1, 系统评价, Meta分析, 病例对照研究

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