Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (12): 859-864.doi: 10.12016/j.issn.2096-1456.2021.12.010

• Review Articles • Previous Articles    

Research progress on the relationship between IL-37 and periodontitis

ZHENG Xu(),XIE Chen,GAO Chang,GUO Zhuling()   

  1. Department of Stomatology, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China
  • Received:2020-12-09 Revised:2021-06-15 Online:2021-12-20 Published:2021-08-17
  • Contact: Zhuling GUO E-mail:524118902@qq.com;604569033@qq.com
  • Supported by:
    National Natural Science Foundation of China(81660270);Scientific Research Projects of Higher Education in Hainan Province(Hnky2020ZD-19);Hainan Provincial Health Industry Research Project(19A200062)

Abstract:

Periodontitis is the inflammation of periodontal tissue caused by dental plaque, which absorbs the alveolar bone and cementum. The immune response triggered by CD4+T cells is the key factor for the aggravation of periodontitis. The activation of dendritic cells and the receptor activator of the NF-κB ligand (RANKL) pathway is an important link in the alveolar bone resorption of periodontal tissue. Pro-inflammatory factors such as interferon-γ (IFN-γ), tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β) also play important roles in the development of periodontitis. Interleukin-37(IL-37), which is a newly discovered cytokine in the IL-1 family, has five shear variants from a to e, among which the clover β-structure encoded by exon 4 plays an important role in the binding of cytokines and the corresponding receptors. IL-37 has strong anti-inflammatory and inhibition of autoimmunity, can enter the nucleus with the help of caspase-1 and bind with Smad proteins to regulate the transcription of pro-inflammatory genes. Extracellular IL-37 can bind to IL-18 binding protein and inhibit the production of pro-inflammatory factors. IL-37 can inhibit the progression of periodontitis by inhibiting the RANKL signaling pathway, inhibiting the proliferation and differentiation of dendritic cells and CD4+T cells, binding to Smad proteins, and releasing pro-inflammatory factors such as IFN-γ and TNF-α. The IL-37 concentration in periodontal tissue can indicate the progression of periodontitis. Few studies have described the interaction between the anti-inflammatory factor IL-37 and periodontitis. Thus, in this paper, the structure and function of IL-37 and the related factors between IL-37 and periodontitis will be reviewed.

Key words: IL-37, periodontitis, immune response, CD4+T cells, dendritic cells, Smads protein, receptor activator of NF-κB ligand, interferon-γ, tumor necrosis factor-α

CLC Number: 

  • R78

Figure 1

The anti-inflammatory effects of IL-37 through intracellular and extracellular pathways IL-1R8: interleukin-1 receptor 8; IL-18BP: interleukin-18 binding protein; IL-18Rα: interleukin-18 receptor α; TLR: toll-like receptor; TNF-α: tumor necrosis factor-α; IFN-γ: interferon-γ"

Figure 2

IL-37 inhibits proliferation and differentiation of dendritic cells and CD4+T cells TLR4: toll-like receptor 4; RANKL: receptor activator of NF-κB ligand; Foxp3: forked head transcription factor 3; TGF-β: transforming growth factor-β; IL: interleukin"

Figure 3

IL-37 delays alveolar bone resorption through inhibiting the RANKL pathway RANKL: receptor activator of NF-κB ligand; RANK: receptor activator of NF-κB; IL: interleukin"

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