Journal of Prevention and Treatment for Stomatological Diseases ›› 2022, Vol. 30 ›› Issue (3): 212-216.DOI: 10.12016/j.issn.2096-1456.2022.03.009

• Review Articles • Previous Articles     Next Articles

Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma

TANG Xiaoyi1(), ZHANG Pan1, WANG Kaiyan2, NIU Lina2(), JIAO Kai3(), XIAO Yuhong1()   

  1. 1. Department of Oral Surgery, 920th Hospital of Joint Logistics Support Force/Kunming Medical University, Kunming 650032, China
    2. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China
    3. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Oral Mucosa, School of Stomatology, the Fourth Military Medical University, Shaanxi 710032, China
  • Received:2021-02-03 Revised:2021-03-13 Online:2022-03-20 Published:2021-12-09
  • Contact: NIU Lina, JIAO Kai, XIAO Yuhong
  • Supported by:
    National Natural Science Foundation of China(81870787)

线粒体功能与口腔鳞状细胞癌关系的研究进展

唐笑怡1(), 张攀1, 王凯燕2, 牛丽娜2(), 焦凯3(), 肖玉鸿1()   

  1. 1.中国人民解放军联勤保障部队第九二〇医院口腔外科 昆明医科大学教学医院,云南 昆明(650032)
    2.军事口腔医学国家重点实验室 口腔疾病国家临床医学研究中心 陕西省口腔疾病重点实验室 第四军医大学口腔医院修复科,陕西 西安(710032)
    3.军事口腔医学国家重点实验室 口腔疾病国家临床医学研究中心 陕西省口腔疾病国际联合研究中心 第四军医大学口腔医院黏膜病科,陕西 西安(710032)
  • 通讯作者: 牛丽娜,焦凯,肖玉鸿
  • 作者简介:唐笑怡,硕士研究生,Email: 670075980@qq.com
  • 基金资助:
    国家自然科学基金项目(81870787)

Abstract:

Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. In recent years, the incidence rate has been increasing. Mitochondria are dynamic organelles involved in various cell behaviors in eukaryotic cells. Mitochondrial dysfunction is closely related to tumor development. As a switch that determines cancer cell death, targeting mitochondria has become the focus of OSCC treatment. This article reviews the relationship between mitochondria and tumorigenesis and development, OSCC treatment, and cisplatin resistant OSCC. Current studies have found that mitochondrial dysfunction promotes cell carcinogenesis, and the mitochondrial morphology and function of cancer cells are significantly changed. The increase of mitochondrial fission improves the invasiveness of cancer cells, and mitophagy dysfunction can induce cancer cell apoptosis. The emergence of drugs and the development of nanotechnology in targeted drug delivery systems have opened up new methods for targeting mitochondria to treat OSCC, reducing the side effects of systemic medication. The cisplatin resistance of OSCC is generated through the mitochondrial pathway, and the mitochondrial function and mutation mechanism of mitochondrial DNA are clarified in order to provide new ideas for targeting mitochondria to treat cisplatin resistant OSCC.

Key words: oral squamous cell carcinoma, tumor, mitochondria, mitochondrial DNA, mitochondrial dysfunction, mitophagy, cell apoptosis, cisplatin resistance

摘要:

口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是头颈部常见的恶性肿瘤,近来发病率呈逐年上升的趋势。线粒体是真核细胞中参与多种细胞行为的动态细胞器,线粒体功能障碍与肿瘤发展关系密切,作为决定癌细胞死亡的开关,靶向线粒体已成为OSCC治疗的重点。本文对线粒体与肿瘤发生发展、OSCC治疗以及顺铂耐药性OSCC的关系进行综述。目前研究发现:线粒体功能障碍促进细胞癌变,癌细胞的线粒体形态及功能均发生显著改变;线粒体裂变的增加提高癌细胞的侵袭性,线粒体自噬功能失调可诱导癌细胞凋亡;新型药物的出现以及定向药物递送系统纳米技术的发展开拓了靶向线粒体治疗OSCC的新方法,降低了全身用药的副作用;OSCC的顺铂耐药性通过线粒体途径产生,明确线粒体功能及线粒体DNA的突变机制,为靶向线粒体治疗顺铂耐药性OSCC提供新思路。

关键词: 口腔鳞状细胞癌, 肿瘤, 线粒体, 线粒体DNA, 线粒体功能障碍, 线粒体自噬, 细胞凋亡, 顺铂耐药性

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