Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (11): 627-633.doi: 10.12016/j.issn.2096-1456.2016.11.002

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Arginine-containing desensitization toothpaste for dentin hypersensitivity: a Meta analysis

NIU Ying-Hui,LI Sha,Ma-Li-Ya-Mu-Gu-Li PATAER,ZHAO Jin()   

  1. Department of Endodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
  • Received:2016-08-03 Revised:2016-08-22 Online:2016-11-20 Published:2016-11-20
  • Contact: Jin ZHAO E-mail:merryljin@sina.com

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Abstract:

Objective Meta analysis was used to evaluate and compare the efficacy of treatment of dentin hypersensitivity with arginine desensitization toothpaste and commonly used desensitization toothpaste. Methods A computerized search of Wanfang, PubMed, web of science, and Cochrane library databases was performed, and a manual retrieval was supplemented. Randomized control trials (RCT) about arginine-containing desensitization toothpaste for dentine hypersensitivity were collected, then data extraction and quality assessment were performed by 2 raters independently. Meta-analysis was carried out by RevMan 5.3 software. Results A total of 7 RCTs were included. All the results were evaluated by the tactile sensitivity test and the air blast test. The mean and standard deviation of each treatment group were analyzed by the random effects model. Meta-analysis results showed there was statistical significance in the therapeutic effects between arginine-containing desensitization toothpaste and potassium-containing desensitization toothpaste(tactile sensitivity test to evaluate: SMD = 1.83, 95% CI BP, 2.58], P ＜ 0.05; cold air assessment: SMD = -1.19, 95% CI [-1.69, -0.69], P ＜ 0.05); However, there was no statistical significance between arginine-containing desensitization toothpaste and strontium-containing desensitization toothpaste (tactile sensitivity test to evaluate: SMD = 0.68, 95% CI [-1.59, 2.96], P ＞ 0.05; cold air assessment: SMD = -0.94, 95% CI [-2.28, 0.40], P ＞ 0.05). Conclusion It shows that arginine-containing desensitization toothpaste has greater effects than potassium-containing desensitization toothpaste for dentin hypersensitivity, but no better effects than strontium-containing desensitization toothpaste.

Key words: Arginine-containing desensitization toothpaste, Dentin hypersensitivity, Systematic review, Meta-analysis, Randomized controlled trial

CLC Number: 

  • R781.2

Figure 1

Retrieval process"

Table 1

Basic characteristics of the studies included in Meta analysis"

纳入研究 例数 （T/C） 干预措施 检测措施 随访时间（周） 研究结果
对照组 试验组
Ayad 2009 38/39 精氨酸 钾盐 探诊、空气检测 8 第2/4/8周时精氨酸>钾盐
Docimo 2009 40/40 精氨酸 钾盐 探诊、空气检测 8 第2/4/8周时精氨酸>钾盐
Docimo 2009 40/40 精氨酸 钾盐 探诊、空气检测 8 第2/4/8周时精氨酸>钾盐
Docimo 2011 50/50 精氨酸 钾盐 探诊、空气检测 8 第2/4/8周时精氨酸>钾盐
Kakar 2012 46/42 精氨酸 钾盐 探诊、空气检测 8 第2/4/8周时精氨酸>钾盐
Hughes 2010 39/39 精氨酸 锶盐 探诊、空气检测 8 第2/4/8周时精氨酸 = 锶盐
Schiff 2011 61/60 精氨酸 锶盐 探诊、空气检测 8 第8周时精氨酸>锶盐

Table 2

Quality evaluation of the included studies"

纳入研究 随机方法 分配隐藏 盲法 失访 基线情况 质量等级
Ayad 2009 未说明 未说明 双盲 无 一致 B
Docimo 2009 未说明 未说明 双盲 无 一致 B
Docimo 2009 未说明 未说明 双盲 无 一致 B
Docimo 2011 未说明 未说明 双盲 无 一致 B
Kakar 2012 计算机随机 不透光信封密封 双盲 无 一致 A
Hughes 2010 随机数字表 未说明 双盲 描述 一致 B
Schiff 2011 随机数字表 未说明 双盲 描述 一致 B

Figure 2

Results of Meta analysis of comparison of the results of detection of contact pressure between arginine desensitization toothpaste and toothpaste containing potassium"

Figure 3

Results of Meta analysis of comparison of cold air blowing test results between arginine desensitization toothpaste and toothpaste containing potassium"

Figure 4

Results of Meta analysis of comparison of the results of detection of contact pressure between arginine desensitization toothpaste and toothpaste containing strontium"

Figure 5

Results of Meta analysis of comparison of cold air blowing test results between arginine desensitization toothpaste and toothpaste containing strontium"

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