Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (12): 793-800.doi: 10.12016/j.issn.2096-1456.2021.12.001

• Expert Commentary • Previous Articles     Next Articles

New progress in the pathogenesis of traumatic temporomandibular joint ankylosis

HU Kaijin(),MA Zhen,WANG Yiming,DENG Tiange()   

  1. State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Air Force Medical University, Xi’an 710032, China
  • Received:2021-05-06 Revised:2021-06-15 Online:2021-12-20 Published:2021-08-17
  • Contact: Kaijin HU,Tiange DENG E-mail:hukaijin2015@126.com;dtgyszc@163.com
  • Supported by:
    National Natural Science Foundation of China(81970954)

Abstract:

Traumatic temporomandibular joint ankylosis refers to fibrous or bony fusion between the condyle and the glenoid fossa. It can cause problems with mouth-opening limitations, mastication difficulties, obstructive sleep apnea and hypopnea syndrome. When traumatic temporomandibular joint ankylosis occurs during childhood, it can cause facial asymmetry, micrognathia, and malocclusion, which significantly affect the physical and mental health. Once temporomandibular joint ankylosis occurs, it will be refractory and recurrent. The pathogenesis of temporomandibular joint ankylosis has not been completely elucidated and has always been a research hotspot in the oral and maxillofacial fields. In this paper, worldwide research was conducted, and the pathogenesis of traumatic temporomandibular joint ankylosis was clarified, such as “damage of condyle”,“disc displacement or rupture”,“damage to the glenoid fossa” and “lateral pterygoid muscle distraction”. The relative pathogenesis hypotheses were summarized, such as “hematoma organization” and “lateral pterygoid muscle distraction osteogenesis”. The related pathogenesis of traumatic temporomandibular joint ankylosis was discussed based on the latest cytology and molecular biology research.

Key words: trauma, temporomandibular joint, ankylosis, pathogenesis, mandibular condyle, articular disc, glenoid fossa, lateral pterygoid muscle, animal model, mesenchymal stem cells, macrophages

CLC Number: 

  • R78

Figure 1

Pathogenesis of temporomandibular joint ankylosis"

[1] Acri TM, Shin K, Seol D, et al. Tissue engineering for the temporomandibular joint[J]. Adv Healthc Mater, 2019, 8(2):e1801236. doi: 10.1002/adhm.201801236.
[2] Deng TG, Liu CK, Wu LG, et al. Association between maximum mouth opening and area of bony fusion in simulated temporomandibular joint bony ankylosis[J]. Int J Oral Maxillofac Surg, 2020, 49(3):369-376. doi: 10.1016/j.ijom.2019.06.030.
doi: 10.1016/j.ijom.2019.06.030
[3] Meng F, Liu Y, Hu K, et al. A comparative study of the skeletal morphology of the temporo-mandibular joint of children and adults[J]. J Postgrad Med, 2008, 54(3):191-194. doi: 10.4103/0022-3859.40960.
pmid: 18626165
[4] Chouinard AF, Kaban LB, Peacock ZS. Acquired abnormalities of the temporomandibular joint[J]. Oral Maxillofac Surg Clin North Am, 2018, 30(1):83-96. doi: 10.1016/j.coms.2017.08.005.
doi: 10.1016/j.coms.2017.08.005
[5] Resnick CM. Temporomandibular joint reconstruction in the growing child[J]. Oral Maxillofac Surg Clin North Am, 2018, 30(1):109-121. doi: 10.1016/j.coms.2017.08.006.
doi: 10.1016/j.coms.2017.08.006
[6] Agarwal B, Yadav P, Roychoudhury A, et al. Does bilateral gap arthroplasty increase the severity of obstructive sleep apnea in patients with temporomandibular joint ankylosis?[J]. J Oral Maxillofac Surg, 2021, 79(6):1344. doi: 10.1016/j.joms.2021.01.015.
[7] Yan YB, Zhang Y, Gan YH, et al. Surgical induction of TMJ bony ankylosis in growing sheep and the role of injury severity of the glenoid fossa on the development of bony ankylosis[J]. J Craniomaxillofac Surg, 2013, 41(6):476-486. doi: 10.1016/j.jcms.2012. 03.011.
doi: 10.1016/j.jcms.2012.03.011
[8] De Roo N, Van Doorne L, Troch A, et al. Quantifying the outcome of surgical treatment of temporomandibular joint ankylosis: a systematic review and meta-analysis[J]. J Craniomaxillofac Surg, 2016, 44(1):6-15. doi: 10.1016/j.jcms.2015.08.019.
doi: 10.1016/j.jcms.2015.08.019
[9] Bathi RJ, Taneja N, Parveen S. Rheumatoid arthritis of TMJ--a diagnostic dilemma?[J]. Dent Update, 2004, 31(3):167-170. doi: 10.12968/denu.2004.31.3.167.
doi: 10.12968/denu.2004.31.3.167
[10] Galié M, Candotto V, Elia G, et al. Temporomandibular joint ankylosis after early mandibular distraction osteogenesis: a new syndrome?[J]. J Craniofac Surg, 2017, 28(5):1185-1190. doi: 10.1097/SCS.0000000000003612.
doi: 10.1097/SCS.0000000000003612
[11] Movahed R, Mercuri LG. Management of temporomandibular joint ankylosis[J]. Oral Maxillofac Surg Clin North Am, 2015, 27(1):27-35. doi: 10.1016/j.coms.2014.09.003.
doi: 10.1016/j.coms.2014.09.003
[12] Valentini V, Vetrano S, Agrillo A, et al. Surgical treatment of TMJ ankylosis: our experience (60 cases)[J]. J Craniofac Surg, 2002, 13(1):59-67. doi: 10.1097/00001665-200201000-00013.
doi: 10.1097/00001665-200201000-00013
[13] Ma D, Zhang S, Pang C, et al. The Application of intraoperative computed tomography in surgical management of temporomandibular joint ankylosis[J]. J Oral Maxillofac Surg, 2021, 79(1): 90.e1-90.e7. doi: 10.1016/j.joms.2020.09.002.
doi: 10.1016/j.joms.2020.09.002
[14] Xia L, Zhang Y, An J, et al. Evaluating the remodeling of condyles reconstructed by transport distraction osteogenesis in the treatment of temporomandibular joint ankylosis[J]. J Craniomaxillofac Surg, 2020, 48(5):494-500. doi: 10.1016/j.jcms.2020.03.004.
doi: 10.1016/j.jcms.2020.03.004
[15] Xia L, He Y, An J, et al. Condyle-preserved arthroplasty versus costochondral grafting in paediatric temporomandibular joint ankylosis: a retrospective investigation[J]. Int J Oral Maxillofac Surg, 2019, 48(4):526-533. doi: 10.1016/j.ijom.2018.07.018.
doi: 10.1016/j.ijom.2018.07.018
[16] Wang HL, Zhang PP, Meng L, et al. Preserving the fibrous layer of the mandibular condyle reduces the risk of ankylosis in a sheep model of intracapsular condylar fracture[J]. J Oral Maxillofac Surg, 2018, 76(9):1951.e1-e24. doi: 10.1016/j.joms.2018.05.01.
doi: 10.1016/j.joms.2018.05.018
[17] Tuncel U, Kostakoglu N, Turan A, et al. The use of temporalis muscle graft, fresh and cryopreserved amniotic membrane in preventing temporomandibular joint ankylosis after discectomy in rabbits[J]. J Craniomaxillofac Surg, 2014, 42(8):1868-1876. doi: 10.1016/j.jcms.2014.07.005.
doi: 10.1016/j.jcms.2014.07.005 pmid: 25218148
[18] Zavodovskaya R, Vapniarsky N, Garcia T, et al. Intra- and extra-articular features of temporomandibular joint ankylosis in the cat (felis catus)[J]. J Comp Pathol, 2020, 175:39-48. doi: 10.1016/j.jcpa.2019.12.006.
doi: S0021-9975(19)30524-9 pmid: 32138841
[19] Liu CK, Meng FW, Tan XY, et al. Clinical and radiological outcomes after treatment of sagittal fracture of mandibular condyle (SFMC) by using occlusal splint in children[J]. Br J Oral Maxillofac Surg, 2014, 52(2):144-148. doi: 10.1016/j.bjoms.2013.10.007.
doi: 10.1016/j.bjoms.2013.10.007
[20] Vincent AG, Ducic Y, Kellman R. Fractures of the mandibular condyle[J]. Facial Plast Surg, 2019, 35(6):623-626. doi: 10.1055/s-0039-1700888.
doi: 10.1055/s-0039-1700888 pmid: 31783418
[21] He D, Ellis E, Zhang Y. Etiology of temporomandibular joint ankylosis secondary to condylar fractures: the role of concomitant mandibular fractures[J]. J Oral Maxillofac Surg, 2008, 66(1):77-84. doi: 10.1016/j.joms.2007.08.013.
[22] 邓天阁, 王磊, 刘平, 等. 颞下颌关节强直动物模型中最大张口度与强直严重程度关系研究[J]. 中国实用口腔科杂志, 2020, 13(12):730-737. doi: 10.19538/j.kq.2020.12.006.
Deng TG, Wang L, Liu P, et al. Correlations between maximum mouth opening and severity of traumatic temporomandibular joint bone ankylosis in the sheep model[J]. Chin J Pract Stomatol, 2020, 13(12):730-737. doi: 10.19538/j.kq.2020.12.006.
[23] Ouyang N, Zhu X, Li H, et al. Effects of a single condylar neck fracture without condylar cartilage injury on traumatic heterotopic ossification around the temporomandibular joint in mice[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2018, 125(2):120-125. doi: 10.1016/j.oooo.2017.10.008.
doi: 10.1016/j.oooo.2017.10.008
[24] Anyanechi CE. Temporomandibular joint ankylosis caused by condylar fractures: a retrospective analysis of cases at an urban teaching hospital in Nigeria[J]. Int J Oral Maxillofac Surg, 2015, 44(8):1027-1033. doi: 10.1016/j.ijom.2015.05.003.
doi: 10.1016/j.ijom.2015.05.003
[25] Marji FP, Anstadt E, Davit A, et al. Pediatric mandibular condylar fractures with concomitant cervical spine injury: a treatment protocol for prevention of temporomandibular joint ankylosis[J]. J Craniofac Surg, 2020, 31(3):e248-e250. doi: 10.1097/SCS.0000000000006178.
doi: 10.1097/SCS.0000000000006178
[26] Pihut M, Gorecka M, Ceranowicz P, et al. The efficiency of anterior repositioning splints in the management of pain related to temporomandibular joint disc displacement with reduction[J]. Pain Res Manag, 2018: 9089286. doi: 10.1155/2018/9089286.
[27] Yan G, Zhou Q, Yang M. A new method to reposition the displaced articular disc for a patient with comminuted condylar fracture[J]. J Craniofac Surg, 2019, 30(4):e373-e376. doi: 10.1097/SCS.0000000000005384.
doi: 10.1097/SCS.0000000000005384
[28] Wang HL, Liu H, Shen J, et al. Removal of the articular fibrous layers with discectomy leads to temporomandibular joint ankylosis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2019, 127(5):372-380. doi: 10.1016/j.oooo.2018.12.002.
doi: 10.1016/j.oooo.2018.12.002
[29] He D, Cai Y, Yang C. Analysis of temporomandibular joint ankylosis caused by condylar fracture in adults[J]. J Oral Maxillofac Surg, 2014, 72(4): 763.e1-9. doi: 10.1016/j.joms.2013.12.015.
doi: 10.1016/j.joms.2013.12.015
[30] He D, Yang X, Wang F, et al. Acute trauma induced disc displacement without reduction and its sequelae[J]. Sci Rep, 2016, 6:32684. doi: 10.1038/srep32684.
doi: 10.1038/srep32684
[31] Liu CK, Liu P, Meng FW, et al. The role of the lateral pterygoid muscle in the sagittal fracture of mandibular condyle (SFMC) healing process[J]. Br J Oral Maxillofac Surg, 2012, 50(4):356-360. doi: 10.1016/j.bjoms.2011.05.015.
doi: 10.1016/j.bjoms.2011.05.015
[32] Meng FW, Hu KJ, Kong L, et al. Morphological evaluation of temporomandibular joint after open and closed treatment of type B diacapsular condylar fractures in sheep[J]. Ann Anat, 2009, 191(3):288-293. doi: 10.1016/j.aanat.2008.12.002.
doi: 10.1016/j.aanat.2008.12.002
[33] Nanthini C, Sathasivasubramanian S, Arunan M. Temporomandibular joint changes in oral submucous fibrosis--a magnetic resonance imaging study[J]. J Clin Exp Dent, 2018, 10(7):e673-e680. doi: 10.4317/jced.54643.
[34] Miyamoto H, Kurita K, Ogi N, et al. Effect of limited jaw motion on ankylosis of the temporomandibular joint in sheep[J]. Br J Oral Maxillofac Surg, 2000, 38(2):148-153. doi: 10.1054/bjom.1999.0206.
doi: 10.1054/bjom.1999.0206
[35] Mohanty S, Kohli S, Dabas J, et al. Fate of the coronoid process after coronoidotomy and its effect on the interincisal opening: a clinical and radiologic assessment[J]. J Oral Maxillofac Surg, 2017, 75(6):1263-1273. doi: 10.1016/j.joms.2017.01.012.
doi: 10.1016/j.joms.2017.01.012
[36] Zhu F, Zhi Y, Xu X, et al. Interpositional arthroplasty of post-traumatic temporomandibular joint ankylosis: a modified method[J]. J Craniomaxillofac Surg, 2021, 49(5):373-380. doi: 10.1016/j.jcms.2021.01.032.
doi: 10.1016/j.jcms.2021.01.032
[37] Ferretti C, Bryant R, Becker P, et al. Temporomandibular joint morphology following post-traumatic ankylosis in 26 patients[J]. Int J Oral Maxillofac Surg, 2005, 34(4):376-381. doi: 10.1016/j.ijom.2004.09.003.
doi: 10.1016/j.ijom.2004.09.003
[38] Yan YB, Duan DH, Zhang Y, et al. The development of traumatic temporomandibular joint bony ankylosis: a course similar to the hypertrophic nonunion?[J]. Med Hypotheses, 2012, 78(2):273-276. doi: 10.1016/j.mehy.2011.10.044.
doi: 10.1016/j.mehy.2011.10.044
[39] Meng FW, Zhao JL, Hu KJ, et al. A new hypojournal of mechanisms of traumatic ankylosis of temporomandibular joint[J]. Med Hypotheses, 2009, 73(1):92-93. doi: 10.1016/j.mehy.2009.01.024.
doi: 10.1016/j.mehy.2009.01.024
[40] Wu D, Yang XJ, Cheng P, et al. The lateral pterygoid muscle affects reconstruction of the condyle in the sagittal fracture healing process: a histological study[J]. Int J Oral Maxillofac Surg, 2015, 44(8):1010-1015. doi: 10.1016/j.ijom.2015.02.004.
doi: 10.1016/j.ijom.2015.02.004
[41] Deng TG, Liu CK, Liu P, et al. Influence of the lateral pterygoid muscle on traumatic temporomandibular joint bony ankylosis[J]. BMC Oral Health, 2016, 16(1):62. doi: 10.1186/s12903-016-0220-1.
doi: 10.1186/s12903-016-0220-1
[42] 李国威, 刘昌奎, 刘平, 等. 大鼠三叉神经运动核-翼外肌投射通路的解剖学研究[J]. 中华口腔医学杂志, 2020, 55(4):259-263. doi: 10.3760/cma.j.cn112144-20191129-00427.
doi: 10.3760/cma.j.cn112144-20191129-00427 pmid: 32268626
Li GW, Liu CK, Liu P, et al. Anatomical study of rat trigeminal motor nucleus-lateral pterygoid muscle projection pathway[J]. Chin J Stomatol, 2020, 55(4):259-263. doi: 10.3760/cma.j.cn112144-20191129-00427.
doi: 10.3760/cma.j.cn112144-20191129-00427 pmid: 32268626
[43] Yan YB, Liang SX, Shen J, et al. Current concepts in the pathogenesis of traumatic temporomandibular joint ankylosis[J]. Head Face Med, 2014, 10:35. doi: 10.1186/1746-160X-10-35.
doi: 10.1186/1746-160X-10-35
[44] Pajarinen J, Lin T, Gibon E, et al. Mesenchymal stem cell-macrophage crosstalk and bone healing[J]. Biomaterials, 2019, 196:80-89. doi: 10.1016/j.biomaterials.2017.12.025.
doi: S0142-9612(17)30834-7 pmid: 29329642
[45] Gibon E, Lu L, Goodman SB. Aging, inflammation, stem cells, and bone healing[J]. Stem Cell Res Ther, 2016, 7:44. doi: 10.1186/s13287-016-0300-9.
doi: 10.1186/s13287-016-0300-9
[46] He LH, Xiao E, Duan DH, et al. Osteoclast deficiency contributes to temporomandibular joint ankylosed bone mass formation[J]. J Dent Res, 2015, 94(10):1392-1400. doi: 10.1177/0022034515 599149.
doi: 10.1177/0022034515599149 pmid: 26250572
[47] Kitaori T, Ito H, Schwarz EM, et al. Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model[J]. Arthritis Rheum, 2009, 60(3):813-823. doi: 10.1002/art.24330.
doi: 10.1002/art.v60:3
[48] Shinohara K, Greenfield S, Pan H, et al. Stromal cell-derived factor-1 and monocyte chemotactic protein-3 improve recruitment of osteogenic cells into sites of musculoskeletal repair[J]. J Orthop Res, 2011, 29(7):1064-1069. doi: 10.1002/jor.21374.
doi: 10.1002/jor.21374 pmid: 21567452
[49] Liang SX, Wang HL, Zhang PP, et al. Differential regulation of blood vessel formation between traumatic temporomandibular joint fibrous ankylosis and bony ankylosis in a sheep model[J]. J Craniomaxillofac Surg, 2019, 47(11):1739-1751. doi: 10.1016/j.jcms.2019.07.032.
doi: S1010-5182(19)30323-3 pmid: 31439411
[50] Yahara Y, Ma X, Gracia L, et al. Monocyte/macrophage lineage cells from fetal erythromyeloid progenitors orchestrate bone remodeling and repair[J]. Front Cell Dev Biol, 2021, 9:622035. doi: 10.3389/fcell.2021.622035.
doi: 10.3389/fcell.2021.622035
[51] Porto GG, Vasconcelos BC, Fraga SN, et al. Development of temporomandibular joint ankylosis in rats using stem cells and bone graft[J]. Int J Oral Maxillofac Surg, 2011, 40(12):1414-1420. doi: 10.1016/j.ijom.2011.07.910.
doi: 10.1016/j.ijom.2011.07.910
[52] Brylka LJ, Schinke T. Chemokines in physiological and pathological bone remodeling[J]. Front Immunol, 2019, 10:2182. doi: 10.3389/fimmu.2019.02182.
doi: 10.3389/fimmu.2019.02182 pmid: 31572390
[53] Huang K, Sun YQ, Chen XF, et al. Psoralen, a natural phytoestrogen, improves diaphyseal fracture healing in ovariectomized mice: a preliminary study[J]. Exp Ther Med, 2021, 21(4):368. doi: 10.3892/etm.2021.9799.
doi: 10.3892/etm.2021.9799 pmid: 33732341
[54] Gerstenfeld LC, Sacks DJ, Pelis M, et al. Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing[J]. J Bone Miner Res, 2009, 24(2):196-208. doi: 10.1359/jbmr.081113.
doi: 10.1359/jbmr.081113 pmid: 19016594
[55] Chen W, Gao B, Hao L, et al. The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation[J]. J Periodontal Res, 2016, 51(5):647-660. doi: 10.1111/jre.12345.
doi: 10.1111/jre.12345 pmid: 26754272
[56] Muire PJ, Mangum LH, Wenke JC. Time course of immune response and immunomodulation during normal and delayed healing of musculoskeletal wounds[J]. Front Immunol, 2020, 11:1056. doi: 10.3389/fimmu.2020.01056.
doi: 10.3389/fimmu.2020.01056
[57] Wang X, Chen X, Lu L, et al. Alcoholism and osteoimmunology[J]. Curr Med Chem, 2021, 28(9):1815-1828. doi: 10.2174/1567201816666190514101303.
doi: 10.2174/1567201816666190514101303
[58] Xing Z, Lu C, Hu D, et al. Multiple roles for CCR2 during fracture healing[J]. Dis Model Mech, 2010, 3(7/8):451-458. doi: 10.1242/dmm.003186.
doi: 10.1242/dmm.003186
[59] Zhao L, Xiao E, He L, et al. Reducing macrophage numbers alleviates temporomandibular joint ankylosis[J]. Cell Tissue Res, 2020, 379(3):521-536. doi: 10.1007/s00441-019-03087-7.
doi: 10.1007/s00441-019-03087-7 pmid: 31522279
[60] Jiang C, Luo P, Li X, et al. Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation[J]. Cell Stress Chaperones, 2020, 25(3):395-406. doi: 10.1007/s12192-020-01079-z.
doi: 10.1007/s12192-020-01079-z
[61] Robinson JL, Johnson PM, Kister K, et al. Estrogen signaling impacts temporomandibular joint and periodontal disease pathology[J]. Odontology, 2020, 108(2):153-165. doi: 10.1007/s10266-019-00439-1.
doi: 10.1007/s10266-019-00439-1
[62] Fajardo M, Liu CJ, Egol K. Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study[J]. Clin Orthop Relat Res, 2009, 467(12):3071-3078. doi: 10.1007/s11999-009-0981-9.
doi: 10.1007/s11999-009-0981-9
[63] Yan YB, Li JM, Xiao E, et al. A pilot trial on the molecular pathophysiology of traumatic temporomandibular joint bony ankylosis in a sheep model. Part II: the differential gene expression among fibrous ankylosis, bony ankylosis and condylar fracture[J]. J Craniomaxillofac Surg, 2014, 42(2):e23-e28. doi: 10.1016/j.jcms.2013.04.008.
doi: 10.1016/j.jcms.2013.04.008
[64] Zhang J, Sun X, Jia S, et al. The role of lateral pterygoid muscle in the traumatic temporomandibular joint ankylosis: a gene chip based analysis[J]. Mol Med Rep, 2019, 19(5):4297-4305. doi: 10.3892/mmr.2019.10078.
[65] Pilmane M, Skagers A. Growth factors, genes, bone proteins and apoptosis in the temporomandibular joint (TMJ) of children with ankylosis and during disease recurrence[J]. Stomatologija, 2011, 13(3):96-101.
pmid: 22071418
[66] Meng FW, Liu YP, Hu KJ, et al. Use of a temporary screw for alignment and fixation of sagittal mandibular condylar fractures with lateral screws[J]. Int J Oral Maxillofac Surg, 2010, 39(6):548-553. doi: 10.1016/j.ijom.2010.01.018.
doi: 10.1016/j.ijom.2010.01.018
[1] SONG Bingqing,REN Biao,CHENG Lei. Research progress on the relationship between Fusobacterium nucleatum and periodontitis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(8): 557-561.
[2] ZUO Xinhui,LI Jun,HAN Xiangzhen,LIU Xiaoyuan,HE Huiyu. Effects of hypoxia inducible factor-1α on osteogenic differentiation and angiogenesis related factors of bone marrow mesenchymal stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 449-455.
[3] LAI Zhanwen,HU Ziyang,PAN Xiao,HAO Yanqing,LIN Zitong. Evaluation of temporomandibular joint space and condylar morphology in patients with anterior open-bite based on cone-beam CT [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 468-473.
[4] WANG Ke,PENG Guoguang,HE Shanzhi,TAN Yulian. Retrospective analysis of the treatment of mandibular condylar sagittal fracture with Kirschner wire in 13 cases [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 474-478.
[5] LI Peihan,LANG Kai,SONG Wen. Construction of a curcumin-siRNA co-delivery system based on mesoporous silica and its effect on M2-type polarization of macrophages [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(5): 306-313.
[6] ZHOU Anqi,LIU Jiayi,JIA Yinan,XIANG Lin. Research progress on the Hippo-YAP signaling pathway mediated osteoimmunology in modulating implant osseointegration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(5): 334-339.
[7] MENG Qingyan,LIU Jun. Research progress on factors related to the difficulty of orthodontic tooth movement [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(5): 340-345.
[8] PAN Yingxiao,GUO Dawei,LI Xin,LU Shulai. Research progress on microRNAs connected with oral lichen planus [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(3): 206-210.
[9] YAN Shanyu,MEI Hongxiang,LI Juan. Role of mesenchymal stem cells migration in bone injury repair [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(12): 854-858.
[10] LI Qi, WANG He, HUANG Zijun, HAN Qianqian. Research progress on the regulatory mechanism of estrogen in periodontal ligament cells repair and the reconstruction of periodontal tissue [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(11): 787-792.
[11] LI Jieting,OUYANG Jin. Diagnosis and treatment experience of granulomatous cheilitis: case report and literature review [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 449-452.
[12] ZHANG Hongqi,LI Xiaojing,MENG Yukun. Different jaw positions and condylar positions in oral therapy [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 399-403.
[13] ZOU Xiaolong,CHEN Yuan,WANG Yan,WANG Jiantao. Research progress on animal models of oral mucositis caused by radiotherapy and chemotherapy [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(5): 322-326.
[14] LIU Junfeng,LIU Conghua,ZHANG Wenzhong,XIAO Hui,Li Shaobing. The effect of the RW-splint on the position and occlusal relationship of class Ⅱ malocclusion patients with temporomandibular disorder [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(4): 224-230.
[15] WANG Yueyang,ZHANG Lili,ZHOU Weiwei,WANG Nan. Retrospective study of flexible fiber splints in the treatment of horizontal root fractures in permanent teeth [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 163-168.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. journal1, 2016, 24(1): 58 -60 .
[2] Juan LI,Ting HUANG,Wen XUE,Hai-yan LI. Clinical efficacy of basic periodontal therapy combined with local medication for erosive oral lichen planus[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(3): 162 -165 .
[3] Ming CHEN,Xi CHEN,Zhen-ting ZHANG. The precision comparison of the denture occlusal plane preparation by the occlusal plane plate between experienced and newly-graduated dentists[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(3): 173 -176 .
[4] Zhong-juan TAN,Yue-ping ZHAO,Yuan-yuan LUO. The research progress of dental pulp regeneration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(6): 374 -377 .
[5] Lan LIAO, Lijun ZENG. Updated research on digitalization in aesthetic restoration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 409 -414 .
[6] Yan-mei DONG. Causes and management of post-treatment apical periodontitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(10): 561 -566 .
[7] LI Chun,LI Yan-hong,LIU Juan. Application of probiotics for dental caries prevention in children[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(9): 558 -560 .
[8] Mingyu SUN, Hanjiang WU. Research progresses in occult lymph node metastasis of oral squamous cancer[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(1): 61 -65 .
[9] Qian-qian HAN,Zhao LIU,Li JIANG,Hui-yi TANG,Xiao-na LI. Effects of LMK-235 on osteoblast/odontoblast differentiation in hPDLCs[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(7): 390 -394 .
[10] Nu MI,Ying GUO,Xiao-yu YANG. Clinical evaluation of anterior teeth aesthetic restoration with thin porcelain laminate veneer[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(10): 589 -593 .
This work is licensed under a Creative Commons Attribution 3.0 License.