Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (4): 264-267.doi: 10.12016/j.issn.2096-1456.2019.04.012

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Research progress on the function and metabolism of d-alanine in bacteria

GUO Xiao,DU Xinmei,CHENG Lei,ZHOU Xuedong,LI Mingyun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Stomatology Hospital of Sichuan University, Chengdu 610041, China
  • Received:2018-05-27 Revised:2018-12-22 Online:2019-04-20 Published:2019-04-28
  • Contact: Mingyun LI E-mail:imingyun@scu.edu.cn

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Abstract:

D-alanine is a chiral molecule of L-alanine that participates in the formation and regulation of cell wall peptidoglycans, phosphoteichoic acid, spore germination and respiratory metabolism in individual bacteria. D-alanine participates in the formation and regulation of biofilm in bacterial communities. The function and metabolism of D-alanine in bacteria are specific, and the enzymes and genes in its metabolic pathway can be used as drug targeting sites. In this paper, the synthesis, metabolism and function of D-alanine in bacteria were reviewed, and the relationship between D-alanine and pathogenicity of Streptococcus mutans was discussed to provide a theoretical basis for candidate targeting sites of anti-caries drugs. According to existing research results, the enzymes and related genes involved in D-alanine metabolism play important roles in the growth and biofilm formation of Streptococcus mutans, and D-alanine is expected to be a target for the design of anti-caries drugs.

Key words: D-alanine, Bacteria, Function, Metabolism, Dental caries, Targeted therapy

CLC Number: 

  • R78
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