Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (5): 280-286.doi: 10.12016/j.issn.2096-1456.2019.05.002

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Recent advances in the application of quaternary ammonium compounds in biomedical materials

JIAO Yang1,CHEN Jihua2,()   

  1. 1. Department of Stomatology, 7th Medical Center of PLA General Hospital, Beijing 100700, China
    2. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China;
  • Received:2018-11-22 Revised:2018-12-24 Online:2019-05-20 Published:2019-05-20
  • Contact: Jihua CHEN


Microbial infections affect people worldwide. Quaternary ammonium salts serve antibacterial, antifungal, antiviral, anti-matrix metalloproteinase and polymerization functions. While the modification of biomaterials with quaternary ammonium salts cannot affect the physical or chemical properties of the biomaterials, this process can confer them with stable biological activity. Currently, quaternary ammonium salts are widely used in the development of functional orthopedic materials, sutures, dressings and dental materials, and the idea of modifying biomedical materials with quaternary ammonium salts has become the most promising, e.g., for preparing antimicrobial biomaterials. Recent studies have found that quaternary ammonium salt-modified antimicrobial monomers are cytotoxic. Therefore, it is of great significance to explore the cytotoxic mechanism of quaternary ammonium salt-modified antimicrobial monomers and determine possible cytoprotective measures for improving the biological safety of these antimicrobial resin-based materials and expanding their clinical applications. In addition, further validation of the clinical efficacy of these biomaterials is particularly important for accurately evaluating the clinical prospects of these biomaterials. Based on a literature review, this paper summarizes the applications and toxicity of biomedical materials modified with quaternary ammonium salts.

Key words: Quaternary ammonium compound, Antibacterial, Orthopedics-related materials, Sutures, Wound dressings, Dental materials, Cytotoxicity, Matrix metalloproteinase

CLC Number: 

  • R78

Figure 1

Schematic illustration of the use of quaternary ammonium compounds in antimicrobial biomedical materials"

Table 1

MIC and MBC of MDPB against several common oral pathogens μg/mL"

变形链球菌 ATCC 25175 2.4 4.8
粘性放线菌 ATCC 15987 4.8 9.6
乳酸杆菌 ATCC 393 2.4 9.6
金黄色葡萄球菌 ATCC 29213 1.2 2.4
血链球菌ATCC 10556 4.8 4.8
牙龈卟啉单胞菌ATCC 33277 1.2 1.2
产黑普氏菌 ATCC 25261 2.4 9.6

Table 2

MIC and MBC of MAE-DB and MAE-HB against several common oral pathogens μg/mL"

变形链球菌 UA159 6.1 12.2 6.1 12.2
粘性放线菌 ATCC15987 6.1 12.2 24.4 48.8
嗜酸乳杆菌 ATCC393 6.1 12.2 3.1 6.2
金黄色葡萄球菌 ATCC29213 12.2 24.4 24.4 48.8
血栓性链球菌ATCC6715 12.2 1.2 6.1 12.2
牙龈卟啉单胞菌 ATCC33277 6.1 12.2 6.1 12.2
产黑普氏菌 ATCC25261 6.1 12.2 6.1 12.2
粪肠球菌 ATCC29212 12.2 24.4 24.4 48.8

Figure 2

Chemical structures of representative quaternary ammonium compounds in antimicrobial biomedical materials"

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