Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (1): 52-55.doi: 10.12016/j.issn.2096-1456.2020.01.009

• Review Articles • Previous Articles     Next Articles

Research status of 3D-printed composite PVA bone tissue engineering scaffolds

LIU Xiaoyuan,ZHANG Kai,HAN Xiangzhen,ZUO Xinhui,LI Jun,HE Huiyu()   

  1. Xinjiang Uygur Autonomous Region Institute of Stomatology, Department of Prosthodontics, the First Affiliated Hospital(Affiliated Stomatological Hospital ) of Xinjiang Medical University, Urumqi 830054, China
  • Received:2019-05-26 Revised:2019-08-01 Online:2020-01-20 Published:2020-01-17
  • Contact: Huiyu HE E-mail:hehuiyu01@126.com

Abstract:

Three dimensionally printed composite porous bone tissue engineering scaffolds have become a research focus. Composite polyvinyl alcohol (PVA) has good biocompatibilityand degradability, but it cannot be prepared independently because it cannot resist highmechanical resistance. This material shows many advantages, such as good biocompatibility, degradability and mechanical properties, when compounded with other materials with good mechanical properties and good biocompatibility. Therefore, 3D printed composite PVA scaffold material can optimize the performance of PVA scaffolds. This article reviews 3D printing bone scaffold technology, polyvinyl alcohol (PVA), and composite PVA scaffolds for in vivo and in vitro bone formation.

Key words: bone defect, 3D printing, stereo lithography appearance, selective laser sintering, fused deposition modeling, ink jet printing, bioink, tissue engineering bone scaffold, polyvinyl alcohol, bone formation

CLC Number: 

  • R78
[1] Turnbull G, Clarke J, Picard F , et al. 3D bioactive composite scaffolds for bone tissue engineering[J]. Bioact Mater, 2017,3(3):278-314.
[2] Chang CH, Lin CY, Liu FH , et al. 3D printing bioceramic porous scaffolds with good mechanical property and cell affinity[J]. PLoS ONE, 2015,10(11):1-15.
[3] Thavornyutikarn B, Chantarapanich N, Sitthiseripratip K , et al. Bone tissue engineering scaffolding: computer-aided scaffolding techniques[J]. Prog Biomater, 2014,3(11):61-102.
[4] Hopkinson N, Dickens P . Rapid manufacturing: an industrial revolution for the digital age[M]. West Sussex, Wiley, 2006: 55-80.
[5] Van Bochove B, Grijpma DW . Photo-crosslinked synthetic biodegradable polymer networks for biomedical applications[J]. Biomater Sci Polym Ed, 2018,11(29):1-49.
[6] He Y, Yang F, Zhao H , et al. Research on the printability of hydrogels in 3D bioprinting[J]. Sci Rep, 2016,6(20):29977-29989.
[7] Gaaz TS, Sulong AB, Akhtar MN , et al. Properties and applications of polyvinyl alcohol, halloysite nanotubes and their nanocomposites[J]. Molecules, 2015,20(12):22833-22847.
[8] Pineda-Castillo S, Bernal-Ballén A, Bernal-López C , et al. Synjournal and characterization of poly(vinyl alcohol)-chitosan-hydroxyapatite scaffolds: a promising alternative for bone tissue regeneration[J]. Molecules, 2018,23(10):2414-2432.
[9] Hasan A, Morshed M, Memic A , et al. Nanoparticles in tissue engineering: applications, challenges and prospects[J]. Int J Nanomedicine, 2018,13(9):5637-5655.
[10] Parhi R . Cross-linked hydrogel for pharmaceutical applications: a review[J]. Adv Pharm Bull, 2017,7(4):515-530.
[11] He HY, Zhang JY, Mi X , et al. Rapid prototyping for tissue-engineered bone scaffold by 3D printing and biocompatibility study[J]. Int J Clin Exp Med, 2015,8(7):11777-11785.
[12] 赵小琦, 丁刘闯, 韩祥祯 , 等. 3D打印鹿角粉/聚乙烯醇支架与纳米级羟基磷灰石/聚乙烯醇支架的性能比较[J]. 口腔医学研究, 2018,34(9):1011-1015.
Zhao XQ, Ding LC, Han XZ , et al. Performance comparison of 3D printed antler powder/polyvinyl alcohol scaffolds and nano-scale Hydroxyapatitle/polyvinyl alcohol scaffolds[J]. J Oral Sci Res, 2018,34(9):1011-1015.
[13] Singh BN, Pramanik K . Development of novel silk fibroin/polyvinyl alcohol/sol-gel bioactive glass composite matrix by modified layer by layer electrospinning method for bone tissue construct generation[J]. Biofabrication, 2017,9(1):015028.
[14] Al-Qarni A, Lewington MR, Wong IH . Reconstruction of focal femoral head cartilage defects with a chitin-based scaffold[J]. Arthrosc Tech, 2016,5(2):257-262.
[15] Shim JH, Won JY, Park JH , et al. Effects of 3D-printed polycaprolactone/β-tricalcium phosphate membranes on guided bone regeneration[J]. Int J Mol Sci, 2017,18(5):1-16.
[16] Shim JH, Moon TS, Yun MJ , et al. Stimulation of healing within a rabbit calvarial defect by a PCL/PLGA scaffold blended with TCP using solid freeform fabrication technology[J]. J Mater Sci, 2012,23(12):2993-3002.
[17] Hwang KS, Choi JW, Kim JH , et al. Comparative efficacies of collagen-based 3D printed PCL/PLGA/β-TCP composite block bone grafts and biphasic calcium phosphate bone substitute for bone regeneration[J]. Materials (Basel), 2017,10(4):421.
[18] 丁刘闯, 赵小琦, 韩祥祯 , 等. 3D打印PVA/nHA支架与SF(丝素蛋白)/PVA/nHA支架的性能比较[J]. 口腔医学, 2018,38(7):598-602.
Ding LC, Zhao XQ, Han XZ , et al. Performance comparison of three-dimensional printed silk fibroin/polyvinyl alcohol /nano-hydroxyapatite scaffold and polyvinyl alcohol /nano-hydroxyapatite scaffold[J]. Stomatol, 2018,38(7):598-602.
[19] 周琦琪, 韩祥祯, 宋艳艳 , 等. 3D 打印羊椎骨粉/聚乙烯醇支架、纳米级羟基磷灰石/聚乙烯醇支架、羊椎骨粉/聚乙烯醇无孔骨板的性能比较[J]. 中国组织工程研究, 2016,20(52):7851-7857.
Zhou QQ, Han XZ, Song YY , et al. Performance comparison of 3D printing sheep vertebral bone meal/polyvinyl alcohol scaffold, nano-hydroxyapatite/polyvinyl alcohol scaffold and sheep vertebral bone meal/polyvinyl alcohol nonporous bone plate[J]. Chin J Tissue Eng Res, 2016,20(52):7851-7857.
[20] Ngadiman NHA, Yusof NM, Idris A , et al. Novel processing technique to produce three dimensional polyvinyl alcohol/maghemite nanofiber scaffold suitable for hard tissues[J]. Polymers (Basel), 2018,10(4):353-371.
[21] Weller WJ . Emerging technologies in upper extremity surgery: polyvinyl alcohol hydrogel implant for thumb carpometacarpal arthroplasty and processed nerve allograft and nerve conduit for digital nerve repairs[J]. Orthop Clin North Am, 2019,50(1):87-93.
[22] Pazos V, Mongrain R, Tardif JC . Polyvinyl alcohol cryogel: optimizing the parameters of cryogenic treatment using hyperelastic models[J]. J Mech Behav Biomed Mater, 2009,2(5):542-549.
[23] Costa-Júnior ES, Barbosa-Stancioli EF, Mansur AAP . Preparation and characterization of chitosan/poly (vinyl alcohol) chemically crosslinked blends for biomedical applications[J]. Carbohydr Polym, 2009,76(3):472-481.
[24] Song Y, Lin K, He S , et al. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin[J]. Int J Nanomedicine, 2018,13(1):505-523.
[25] Somasundaram P, Santhosh S, Raymond W . Osteogenic potential of graphene in bone tissue engineering scaffolds[J]. Materials (Basel), 2018,11(8):1430-1448.
[26] 张旭婧 . 3D同轴打印组织工程骨支架成型工艺与实验研究[D]. 新疆维吾尔自治区: 新疆大学, 2017.
Zhang XJ . 3D coaxial print bone engineering scaffold molding process and experimental research[D]. Xinjiang Uygur Autonomous Region: Xinjiang University, 2017.
[1] REN Lizhi,SUN Rui. New progress in the clinical application of GBR membrane materials [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 404-408.
[2] WANG Yamin,ZHOU Zhen,DAO Junfeng,CHEN Qiyue,LIU Wenjing,SONG Guangbao. Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(4): 236-240.
[3] XIAO Wenlan,HU Chen,RONG Shengan,ZHU Chenyou,WU Yingying. Application of dentin in bone tissue engineering [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(2): 127-130.
[4] SHAO Yanxiong,ZHOU Haiwen. Treating recurrent aphthous stomatitis with oral mucoadhesive films containing chitosan: a clinical randomized controlled study [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(1): 36-40.
[5] OU Zhanpeng,ZHANG Hanqing,LI Qunxing,LIN Xinyu,FAN Song,LI Jinsong. Application of virtual surgical planning in the surgical treatment of osteoradionecrosis of mandible [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(9): 561-568.
[6] HOU Jinsong,ZHANG Yadong. Difficulties and prevention and management of serious complications in surgical treatment of osteoradionecrosis of jaw [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(7): 409-416.
[7] LIU Ziyan,DAI Qun,XIAO Fang. Application of digital implant guide plate in oral implant restoration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(5): 337-340.
[8] XU Xiongcheng,ZHONG Quan,LUO Kai. Application of 3D printing technology in preparation of scaffolds for periodontal tissue regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(3): 189-193.
[9] Xueqian LI,Qiao ZHANG,Xiaoxin ZHANG,Yufeng ZHANG. Osteogenic potential of recombinant human bone morphogenetic protein-2 combined with Bio-oss bone substitute in implant restorations in anterior esthetic region [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(9): 584-591.
[10] Jun HE, Ziliang LI, Zhigang XIE. Research progress on osteoinductive properties of bone substitute materials [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(2): 124-127.
[11] Jiang CHEN,Xuxi CHEN,Lin ZHOU. The effect of the osteoimmunomodulatory mechanism on implant osseointegration and bone biomaterials induced bone regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(10): 613-620.
[12] Haibin LU, Lei WAN, Mingdeng RONG, Xueyang ZHANG, Yuan SU. Clinical effects of combined application of Er: YAG laser and guided bone regeneration in treatment of peri-implantitis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(7): 430-434.
[13] Jin-quan HE,Ke-xiong OUYANG,Chao-jian WANG,Jun-wei ZHANG,Luo HANG,Wei-qi WANG,Luan-qiu CHEN,Zheng-guo PIAO. Application of cone beam CT in evaluating the bone defect volume in alveolar cleft [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(5): 293-296.
[14] XU Jing. The influence of the impacted mandibular third molar extraction on the distal periodontal tissue of the mandibular second molar [J]. journal1, 2016, 24(1): 11-14.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Hong-chang LAI,Jun-yu SHI. Maxillary sinus floor elevation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(1): 8 -12 .
[2] Pin ZHOU, Yang-fei LI. MRI study of temporomandibular joint disc position in asymptomatic volunteers[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(4): 239 -244 .
[3] Xinxin XIA, Fang FANG, Lijuan CHENG. Shaping ability of Pathfile and WaveOne in simulated root canals[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(6): 365 -368 .
[4] Yuanhong LI, Xinyi FANG, Yu QIU, Lei CHENG. Experimental study on the effects of green tea on salivary flow rate and pH value[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(9): 560 -564 .
[5] Chengzhang LI. Masticatory muscles in occlusion[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(12): 755 -760 .
[6] . [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(1): 1 .
[7] Zhirong WU, Shiguang Huang. Research progress on the etiology, clinical examination and treatment of peri-implantitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(6): 401 -405 .
[8] Xiaowu YAO, Shisheng CHEN, Zizheng LU, Minxiao LIN. Clinical report and literature review on the amyloidosis of salivary glands[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 533 -536 .
[9] Lan LIAO, Lijun ZENG. Updated research on digitalization in aesthetic restoration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 409 -414 .
[10] Yu LU, Chengxia LIU, Zhongjun LIU. Role of TRAF6 in inflammatory responses of human osteoblast-like cells with Enterococcusfaecalis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(7): 420 -425 .
This work is licensed under a Creative Commons Attribution 3.0 License.