Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (6): 361-366.DOI: 10.12016/j.issn.2096-1456.2020.06.004

• Cinical Study • Previous Articles     Next Articles

Clinical effect of platelet-rich fibrin combined with bone substitute in alveolar ridge preservation

ZHANG Yun,WANG Yanmei,HE Jiacai()   

  1. Dental Implant Center, Stomatologic Hospital, Anhui Medical University, Anhui 230032, China
  • Received:2019-11-18 Revised:2020-02-17 Online:2020-06-20 Published:2020-05-28
  • Contact: Jiacai HE

富血小板纤维蛋白联合骨替代材料应用于牙槽嵴位点保存术的临床效果

张运,王彦梅,何家才()   

  1. 安徽医科大学附属口腔医院种植中心,安徽 合肥(230032)
  • 通讯作者: 何家才
  • 作者简介:张运,医师,在读硕士研究生,Email: 584827286@qq.com
  • 基金资助:
    国家自然科学基金项目(81771117);高校学科(专业)拔尖人才学术资助重点项目(gxbjZD2016028)

Abstract:

Objective To study the clinical outcomes of implanting platelet rich fibrinogen (PRF) mixed with Bio-Oss® in the extraction socket for alveolar ridge preservation and to provide evidence for clinical application. Methods Thirty-six patients who underwent alveolar ridge preservation were enrolled. Thirty-six extraction sites were divided into two groups: PRF mixed with Bio-Oss® group (test group) and Bio-Oss® alone (control group). Bone dimensional changes in height and width were measured by CBCT before and 6 months after surgery, and early soft tissue healing and postoperative pain sensation were evaluated clinically 1 week after surgery. Results There was no significant difference in the alveolar bone height (-1.48 ± 0.40) mm between the test group and the control group. The difference in the alveolar bone width between the test group (-1.09 ± 0.42) mm and the control group (-1.35 ± 0.22) mm was statistically significant (z=-2.63, P=0.01). The postoperative pain score of the test group was 2.39 ± 1.20, and that of the control group was 3.39 ± 1.65, the difference was statistically significant (t=-2.083, P=0.045). There was no significant difference in soft tissue healing between the test group and the control group. Conclusion The use of PRF mixed with Bio-Oss ®in the alveolar ridge preservation procedure can reduce alveolar bone absorption and postoperative pain.

Key words: extraction socket, alveolar ridge preservation, platelet-rich fibrinogen, Bio-Oss®bone substitute, early soft tissue healing, postoperative pain, alveolar bone height, alveolar bone width

摘要:

目的 探讨拔牙窝内植入富血小板纤维蛋白(platelet rich fibrinogen,PRF)混合Bio-Oss®骨粉进行牙槽嵴保存术的效果,为临床应用提供证据。方法 进行牙槽嵴保存术的患者36例,36个拔牙位点,分成两组:PRF混合Bio-Oss®骨粉组(试验组)和单独使用Bio-Oss®骨粉组(对照组),在术前和术后6个月拍摄CBCT测量牙槽骨高度和宽度的变化,术后1周临床评估早期软组织愈合和疼痛感觉情况。结果 试验组骨高度变化(-1.48 ± 0.40)mm和对照组(-1.49 ± 0.23)mm差异无统计学意义。试验组骨宽度变化(-1.09 ± 0.42)mm和对照组宽度变化(-1.35 ± 0.22)mm差异有统计学意义(Z=-2.63,P=0.01)。试验组术后疼痛评分2.39 ± 1.20,对照组3.39 ± 1.65,差异有统计学意义(t=-2.083,P=0.045);试验组和对照组软组织愈合差异无统计学意义。结论 在牙槽嵴保存术中利用PRF混合Bio-Oss ®骨粉可以减少牙槽骨的吸收和减轻术后疼痛。

关键词: 拔牙窝, 牙槽嵴保存术, 富血小板纤维蛋白, Bio-Oss®骨粉, 早期软组织愈合, 术后疼痛, 牙槽骨高度, 牙槽骨宽度

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