Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (6): 361-366.DOI: 10.12016/j.issn.2096-1456.2020.06.004

• Cinical Study • Previous Articles     Next Articles

Clinical effect of platelet-rich fibrin combined with bone substitute in alveolar ridge preservation

ZHANG Yun,WANG Yanmei,HE Jiacai()   

  1. Dental Implant Center, Stomatologic Hospital, Anhui Medical University, Anhui 230032, China
  • Received:2019-11-18 Revised:2020-02-17 Online:2020-06-20 Published:2020-05-28
  • Contact: Jiacai HE



  1. 安徽医科大学附属口腔医院种植中心,安徽 合肥(230032)
  • 通讯作者: 何家才
  • 作者简介:张运,医师,在读硕士研究生,Email:
  • 基金资助:


Objective To study the clinical outcomes of implanting platelet rich fibrinogen (PRF) mixed with Bio-Oss® in the extraction socket for alveolar ridge preservation and to provide evidence for clinical application. Methods Thirty-six patients who underwent alveolar ridge preservation were enrolled. Thirty-six extraction sites were divided into two groups: PRF mixed with Bio-Oss® group (test group) and Bio-Oss® alone (control group). Bone dimensional changes in height and width were measured by CBCT before and 6 months after surgery, and early soft tissue healing and postoperative pain sensation were evaluated clinically 1 week after surgery. Results There was no significant difference in the alveolar bone height (-1.48 ± 0.40) mm between the test group and the control group. The difference in the alveolar bone width between the test group (-1.09 ± 0.42) mm and the control group (-1.35 ± 0.22) mm was statistically significant (z=-2.63, P=0.01). The postoperative pain score of the test group was 2.39 ± 1.20, and that of the control group was 3.39 ± 1.65, the difference was statistically significant (t=-2.083, P=0.045). There was no significant difference in soft tissue healing between the test group and the control group. Conclusion The use of PRF mixed with Bio-Oss ®in the alveolar ridge preservation procedure can reduce alveolar bone absorption and postoperative pain.

Key words: extraction socket, alveolar ridge preservation, platelet-rich fibrinogen, Bio-Oss®bone substitute, early soft tissue healing, postoperative pain, alveolar bone height, alveolar bone width


目的 探讨拔牙窝内植入富血小板纤维蛋白(platelet rich fibrinogen,PRF)混合Bio-Oss®骨粉进行牙槽嵴保存术的效果,为临床应用提供证据。方法 进行牙槽嵴保存术的患者36例,36个拔牙位点,分成两组:PRF混合Bio-Oss®骨粉组(试验组)和单独使用Bio-Oss®骨粉组(对照组),在术前和术后6个月拍摄CBCT测量牙槽骨高度和宽度的变化,术后1周临床评估早期软组织愈合和疼痛感觉情况。结果 试验组骨高度变化(-1.48 ± 0.40)mm和对照组(-1.49 ± 0.23)mm差异无统计学意义。试验组骨宽度变化(-1.09 ± 0.42)mm和对照组宽度变化(-1.35 ± 0.22)mm差异有统计学意义(Z=-2.63,P=0.01)。试验组术后疼痛评分2.39 ± 1.20,对照组3.39 ± 1.65,差异有统计学意义(t=-2.083,P=0.045);试验组和对照组软组织愈合差异无统计学意义。结论 在牙槽嵴保存术中利用PRF混合Bio-Oss ®骨粉可以减少牙槽骨的吸收和减轻术后疼痛。

关键词: 拔牙窝, 牙槽嵴保存术, 富血小板纤维蛋白, Bio-Oss®骨粉, 早期软组织愈合, 术后疼痛, 牙槽骨高度, 牙槽骨宽度

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