Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (3): 184-188.DOI: 10.12016/j.issn.2096-1456.2021.03.007

• Review Articles • Previous Articles     Next Articles

Research progress on Streptococcus mutans phages in the prevention of dental caries

LI Yuhan1(),LI Jiaxin1,ZHANG Shiming1,ZHANG Yaohua1,LI Yuqing1,ZENG Jumei2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu 610041, China
  • Received:2020-04-30 Revised:2020-06-21 Online:2021-03-20 Published:2021-01-12
  • Contact: Jumei ZENG
  • Supported by:
    National Natural Science Foundation of China(31870065);Fundamental Research Funds for the Central Universities(YJ201985);Undergraduate′s Platform for Innovation and Entrepreneurship Training Program of Sichuan university(201910611603)



  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院,四川 成都(610041)
    2.四川大学华西公共卫生学院/华西第四医院,四川 成都(610041)
  • 通讯作者: 曾菊梅
  • 作者简介:李雨含,本科在读,
  • 基金资助:


The Streptococcus mutans (S. mutans) phage, as one of the principal pathogenic bacteria of dental caries, is a main cause of the formation and development of dental caries due to its overproliferation in dental plaque biofilms. Bacterial viruses, also known as bacteriophages, have the capability of specifically infecting bacteria and effectively degrading bacterial biofilms. S. mutans phages, therefore, may prevent and control caries. Therapy based on phages has been applied in many fields, but the application of S. mutans phages in caries remains exploratory. This article will review the research progress of S. mutans phages in clinical caries prevention, aiming to provide a new idea for the clinical prevention of caries. The results of the literature review show that the living bacteriophage system has the advantages of high specificity, high affinity and good safety. However, due to its unstable structure, it can be processed into a more stable formulation by freeze-drying, spray drying, adding stability enhancers, or incorporating bacteriophages into ointments, biodegradable polymer matrices or particles to a certain extent to improve stability. The lysozyme produced by phages can digest the bacterial cell wall and release the assembled phage particles, which effectively cleave biofilms. In addition, the antigen binding fragment library for cariogenic pathogens was screened by phage display technology, and the purpose of caries prevention and treatment was achieved by passive immunization of antigen binding fragments. However, the host range of bacteriophages is narrow, so this kind of problem can be overcome by phage combined with traditional therapy or other drug use or cocktail therapy with multiple phages in clinical caries prevention and control.

Key words: Streptococcus mutans, bacteriophage, dental caries, prevention of dental caries, phage therapy, lyase, biofilm, cocktail therapy



关键词: 变异链球菌, 噬菌体, 龋病, 龋病防治, 噬菌体疗法, 裂解酶, 生物膜, 鸡尾酒治疗

CLC Number: