口腔疾病防治 ›› 2018, Vol. 26 ›› Issue (5): 338-340.DOI: 10.12016/j.issn.2096-1456.2018.05.012

• 综述 • 上一篇    

间隙连接蛋白43在口腔鳞状细胞癌中的研究进展

周丽娟(综述)(), 谢思明(审校)()   

  1. 暨南大学口腔医学院, 广东 广州(510632)
  • 收稿日期:2017-08-01 修回日期:2017-08-17 出版日期:2018-05-20 发布日期:2018-08-30
  • 作者简介:

    【作者简介】 周丽娟,医师,硕士研究生,Email:995610344@qq.com

  • 基金资助:
    广东省科技计划项目(2014A020212585)

Progress in research on connexin 43 in oral squamous cell carcinoma

Lijuan ZHOU(), Siming XIE()   

  1. School of Stomatology, Jinan University, Guangzhou 510632, China
  • Received:2017-08-01 Revised:2017-08-17 Online:2018-05-20 Published:2018-08-30

摘要:

细胞间隙连接是普遍存在于动物组织中的一种细胞连接形式,介导相邻细胞间的信息、能量和物质的交换。研究表明,间隙连接蛋白43(connexin 43,Cx43)基因的异常表达与肿瘤的发生发展密切相关,本文就Cx43异常表达与口腔鳞状细胞癌的相关研究进展作一综述。

关键词: 口腔鳞状细胞癌, 间隙连接蛋白43, 细胞连接通讯, 舌鳞状细胞癌, 磷酸化

Abstract:

Cell gap junctions are a universal form of cellular connection in animal tissue that mediate the exchange of information, energy and material between adjacent cells. Clinical studies have demonstrated that the abnormal expression of the connexin 43 (Cx43) gene is closely associated with carcinogenesis and tumor progression. The present study reviewed relevant studies concerning the association between abnormal expression of Cx43 and oral squamous cell carcinoma as well as communication abnormalities of cell gap junctions.

Key words: Oral squamous cell carcinoma, Cx43, Gap junction intercellular communication, Tongue squamous cell carcinoma, Phosphorylation

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