Journal of Prevention and Treatment for Stomatological Diseases ›› 2017, Vol. 25 ›› Issue (4): 227-230.doi: 10.12016/j.issn.2096-1456.2017.04.005

• Cinical Study • Previous Articles     Next Articles

Relationship of clinical index between rheumatoid arthritis and chronic periodontitis

Wei-ni XIN1(), Zhi-duo HOU2, Yao GONG3   

  1. 1. Stomatology Department, The First Affiliated Hospital of Shantou University Medical College, Shantou 515000, China
    2. Rhematology Department, The First Affiliated Hospital of Shantou University Medical College, Shantou 515000, China
    3. Rhematological laboratory, Shantou University Medical College, Shantou 515000, China
  • Received:2016-09-04 Revised:2016-09-26 Online:2017-04-20 Published:2018-09-03

Abstract:

Objective To explore the relationship betweenrheumatoid arthritis (RA) and chronic periodontitis (CP). Methods A total of 48 RA patients were recruited from the Rhematology Department of The First Affiliated Hospital of Shantou University Medical College (SUMC). RA patients were matched on age and gender with healthy controls, who were recruited from the Stomatology Department. Dental parameters including unstimulated salivary flow rate(UWS), stimulated salivary flow rate (SWS), bleeding on probe (BOP), periodontal probing pocket (PD), clinical attachment level (CAL) and decayed, missing and filling (DMF) were recorded in all cases. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and Anticyclic citrullinated peptide antibody (Anti-CCP) were also recorded in RA patients. Results There were significant difference between RA group and health control group on salivary flow rate, BOP, PD, CAL and DMF (P< 0.001). Higher percentage of RA patients were diagnosed as periodontal disease than those in control group (P< 0.001). There was relationship between CAL and Anti-CCP antibody (P< 0.001). Conclusion RA patients have higher risk of CP, and there might be relationship between RA and CP.

Key words: Chronic periodontitis, Rheumatoid arthritis, Anticycliccitrullinated peptide antibody, Salivary flow rate, Clinical attachment level

CLC Number: 

  • R781.4

Table 1

Clinical index of RA group and control group"

变量 RA组 对照组 P
性别
男(例) 9(18.8%) 10(23.8%) -
女(例) 39(81.3%) 32(76.2%) -
年龄(岁) 54.8 ± 10.9
(25~74)
53.5 ± 12.6
(26~78)
-
牙周疾病
慢性牙周炎(例) 17(35.4%) 3(7.1%) < 0.001
(χ2=20.1)
牙龈炎(例) 22(45.8%) 13(31.0%)
健康牙龈(例) 9 (18.8%) 26 (61.9%)
UWS(g/min) 0.06 ± 0.02 0.38 ± 0.24 < 0.001
SWS(g/min) 1.82 ± 0.60 3.26 ± 2.01 < 0.001
CAL(mm) 1.3 ± 1.8 0.2 ± 0.7 < 0.001
PD(mm) 2.9 ± 1.9 1.7 ± 1.1 < 0.001
BOP(%) 45.1% ± 15.9% 28.4% ± 16.5% < 0.001
D 5.0 ± 2.3 2.8 ± 1.7 < 0.001
M 5.9 ± 2.8 4.4 ± 2.5 0.009
F 6.1 ± 2.6 3.0 ± 1.2 < 0.001
DMF 17.0 ± 4.3 10.2 ± 3.5 < 0.001
ESR 38.2 ± 12.2 -
CRP 20.7 ± 16.5 -
Anti-CCP 111.3 ± 69.0 -

Table 2

Relationship of clinical index in RA group"

变量 ESR CRP Anti-CCP 抗体
r P r P r P
UWS(g/min) 0.16 0.28 0.21 0.16 0.06 0.69
SWS(g/min) -0.06 0.67 -0.11 0.45 -0.19 0.21
CAL(mm) -0.18 0.55 -0.13 0.36 0.37 0.01
PPD(mm) -0.31 0.03 -0.07 0.61 0.22 0.14
BOP(%) -0.20 0.16 -0.11 0.44 0.27 0.06
D -0.12 0.44 -0.12 0.41 0.15 0.31
M -0.15 0.32 -0.11 0.41 0.15 0.31
F 0.08 0.60 0.13 0.38 0.12 0.43
DMF -0.11 0.47 -0.06 0.69 0.27 0.07
[1] Alamanos Y, Drosos AA.Epidemiology of adult rheumatoid arthritis[J]. Autoimmunity Reviews, 2005, 4(3): 130-136.
[2] Costenbader KH, Karlson EW.Cigarette smoking and autoimmune disease: what can we learn from epidemiology?[J]. Lupus, 2006, 15(11): 737-45.
[3] de Smit MJ, Westra J, Brouwer E, et al. Periodontitis and rheumatoid arthritis: what do we know?[J]. Journal of Periodontology, 2015, 86(9): 1-10.
[4] Blaizot A, Monsarrat P, Constantin A, et al.Oral health-related quality of life among outpatients with rheumatoid arthritis[J]. International Dental Journal, 2013, 63(3): 145-153.
[5] Helenius LM, Tervahartiala PI, Al SJ, et al.Clinical, radiographic and MRI findings of the temporomandibular joint in patients with different rheumatic diseases[J]. International Journal of Oral &Maxillofacial Surgery, 2006, 35(11): 983-989.
[6] Silva MLE, Carvalho CN, Leão JC, et al.Effect of xerostomia on the functional capacity of subjects with rheumatoid arthritis[J]. J Rheumatol, 2016, 43(10): 1795-1800.
[7] Bartold PM, Marshall RI, Haynes DR.Periodontitis and rheumatoid arthritis: a review[J]. Journal of Periodontology, 2005, 76(11 Suppl): 2066-2074.
[8] 朱习华, 刘丽, 许文青. 牙周病与糖尿病关联性的Meta分析[J]. 广东牙病防治, 2014, 22(2): 76-78.
[9] Ogrendik M.Rheumatoid arthritis is linked to oral bacteria: etiological association[J]. Modern Rheumatology, 2009, 19(5): 453-456.
[10] Chaudhari AU, Byakod GN, Waghmare PF, et al.Correlation of levels of interleukin-1β in gingival crevicular fluid to the clinical parameters of chronic periodontitis[J]. Journal of Contemporary Dental Practice, 2011, 12(1): 52-59.
[11] Kobayashi T, Murasawa A, Ito S, et al.Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults[J]. Journal of Periodontology, 2009, 3(80): 792-799.
[12] Arnett FC, Edworthy SM, Bloch DA, et al.The american Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis[J]. Arthritis Rheum, 1988, 31(3): 315-324.
[13] Zeng QY, Chen R, Darmawan J, et al.Rheumatic diseases in China[J]. Arthritis Research & Therapy, 2008, 10(1): 1383-1384.
[14] 曾庆馀, 肖征宇, 陈肃标, 等. 风湿痛的相关危险因素研究: 汕头地区流行病学调查[J]. 中华流行病学杂志, 2005, 26(9): 711-715.
[15] 孙涛, 王松灵. 唾液SIgA的结构及功能研究[J]. 北京口腔医学, 2000, 8(4): 200-203.
[16] Abdelsalam SK, Hashim NT, Elsalamabi EM, et al.Periodontal status of rheumatoid arthritis patients in khartoum state[J]. Bmc Research Notes, 2011, 4(1): 1-6.
[17] Ulrich R, Käber MD, Alexander Michel MD, et al.Risk for periodontal disease in patients with longstanding rheumatoid arthritis[J]. Arthritis & Rheumatism, 1997, 40(12): 2248-2251.
[18] Uysal H, Bockermann R, Nandakumar KS, et al.Structure and pathogenicity of antibodies specific for citrullinated collagen type Ⅱ in experimental arthritis[J]. Journal of Experimental Medicine, 2009, 206(2): 449-462.
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