Journal of Prevention and Treatment for Stomatological Diseases ›› 2017, Vol. 25 ›› Issue (6): 354-359.doi: 10.12016/j.issn.2096-1456.2017.06.003

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Association between -590C/T polymorphisms of interleukin-4 gene and periodontitis: A meta-analysis

Xaowei JIA1(), Yan MA2, Xiantao ZENG3, Yadi YUAN1, Yingmei LIN1, Jun SHAO1, Jibin ZHANG4()   

  1. Department of Stomatology Guangzhou Hospital of Integrated Traditional and West Medicine Guangzhou 510800 China
    Department of Stomatology Guangzhou Hospital of Integrated Traditional and West Medicine Guangzhou 510800 China
    Department of Stomatology Guangzhou Hospital of Integrated Traditional and West Medicine Guangzhou 510800 China
    Department of Stomatology Guangzhou Hospital of Integrated Traditional and West Medicine Guangzhou 510800 China
  • Received:2017-01-08 Revised:2017-03-09 Online:2017-06-20 Published:2018-09-03

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Abstract:

Objective To evaluate the relationship between-590C/T polymorphisms of interleukin-4 gene and periodontitis by meta-analysis. Methods Databases including PubMed, EMbase, Web of Science, CBM, CNKI, Wanfang and VIP, were searched from their establishment to December 31, 2016. Only case-control studies on the association between -590C/ T polymorphisms of interleukin-4 gene and periodontitis were selected, and the references of those selected studies were searched by hand. Assessment and data extraction were conducted by 2 reviewers independently, and the meta-analysis was performed with the R 3.3.1 software.Results The meta-analysis showed that there was no association between the IL-4-590C/T polymorphism and periodontitis susceptibility (T vs C: OR=1.19, 95%CI=0.81~1.76, P =0.37). Subgroup analysis showed that the IL-4 -590 TT was associated with periodontitis in Caucasians (TT vs CT: OR=1.75, 95%CI=1.10 ~ 2.78, P = 0.02), but no significant association in Asians (P =0.63). Meanwhile, IL-4 gene polymorphisms were not significantly associated with the susceptibility of chronic periodontitis (CP) or aggressive periodontitis (AgP) ( e. g. T vs C, CP: P=0.45; AgP: P =0.45). Conclusion Based on current evidence, the polymorphisms of IL-4-590C/T are associated with the increased risk of periodontitis in Caucasians.

Key words: Periodontitis, Interleukin-4, Polymorphism, Gene, Meta-analysis

CLC Number: 

  • R781.4

Table 1

Characteristics of studies included in meta-analysis"

作者 国家 种族 病种 对照组来源 试验组吸烟者（%） 基因分型方法 HWE P值 NOS评分
Kang 2003[6] 韩国 亚洲人 CP HB 37.5 PCR 0.28 7
Scarel 2003[7] 巴西 高加索人 CP HB 0 PCR-RFLP 0.74 7
Scarel 2003[7] 巴西 混合 CP HB 0 PCR-RFLP 0.43 7
Gonzales 2004[8] 欧洲 高加索人 AgP PB NA PCR-RFLP 0.18 7
Gonzales 2004[8] 日本 亚洲人 AgP PB NA PCR-RFLP 0.09 7
Gonzales 2007[9] 德国 高加索人 AgP PB 12 PCR-RFLP 0.83 7
Kara 2007[10] 土耳其 高加索人 CP PB 0 PCR-RFLP 0.48 7
Holla 2008[11] 捷克 高加索人 CP PB 31.3 PCR-RFLP 0.53 7
Hooshmand 2008[12] 伊朗 亚洲人 CP PB 0 PCR-RFLP 0.35 7
Hooshmand 2008[12] 伊朗 亚洲人 AgP PB 0 PCR-RFLP 0.35 7
胡万春 2008[13] 中国 亚洲人 CP PB 0 PCR-RFLP 0.04 6
Anovazzi 2010[14] 巴西 高加索人 CP HB 15.2 PCR-RFLP 0.04 6
Atanasovska 2011[15] 马其顿 高加索人 CP HB 0 PCR-RFLP <0.05 6
Loo 2012[16] 中国 亚洲人 CP PB NA PCR 0.002 6
陈栋 2012[17] 中国 亚洲人 CP HB NA PCR 0.07 7
刘溦 2015[18] 中国 亚洲人 CP HB 27.9 PCR-RFLP 0.65 7

Figure 1

Flow chart from identification of eligible studies to final inclusion"

Table 2

Meta-analysis of association between IL-4 -590 C/T Polymorphisms and Periodontitis"

基因型
及亚组		 研究
数量		 异质性检验 相关性分析结果
P值 I2值 OR 95% CI P（OR）
T vs C
Overall 16 < 0.01 89.9% 1.19 [0.81~1.76] 0.37
HWE（Y） 12 0.18 27.1% 1.02 [0.83~1.25] 0.84
Caucasian 7 0.23 26.2% 1.21 [0.98~1.50] 0.08
Asian 8 < 0.01 93.6% 1.27 [0.64~2.51] 0.49
CP 12 < 0.01 92.1% 1.2 [0.75~1.90] 0.45
AgP 4 0.26 25.5% 1.17 [0.77~1.78] 0.45
TT vs CC
Overall 16 < 0.01 85.8% 1.65 [0.69~3.98] 0.34
HWE（Y） 12 0.26 19.0% 1.02 [0.62~1.66] 0.94
Caucasian 7 0.96 0.0% 1.75 [1.10~2.78] 0.02
Asian 8 < 0.01 92.2% 1.51 [0.29~7.94] 0.63
CP 12 < 0.01 88.8% 1.55 [0.53~4.53] 0.42
AgP 4 0.42 0.0% 1.72 [0.78~3.80] 0.18
CT vs CC
Overall 16 < 0.01 81.0% 1.26 [0.76~2.10] 0.37
HWE（Y） 12 0.24 24.7% 1 [0.72~1.38] 0.98
Caucasian 7 0.00 73.2% 1.14 [0.69~1.88] 0.62
Asian 8 < 0.01 87.5% 1.37 [0.45~4.22] 0.58
CP 12 < 0.01 84.9% 1.37 [0.73~2.58] 0.39
AgP 4 0.16 42.3% 0.96 [0.48~1.89] 0.9
TT + CT vs CC
Overall 16 < 0.01 85.2% 1.38 [0.81~2.36] 0.24
HWE（Y） 12 0.21 23.7% 1.02 [0.75~1.38] 0.9
Caucasian 7 0.01 65.4% 1.23 [0.81~1.86] 0.34
Asian 8 < 0.01 91.2% 1.59 [0.48~5.32] 0.45
CP 12 < 0.01 88.5% 1.48 [0.75~2.91] 0.26
AgP 4 0.29 20.5% 1.06 [0.62~1.81] 0.84
TT vs CC + CT
Overall 16 < 0.01 84.9% 1.3 [0.73~2.31] 0.38
HWE（Y） 12 0.25 19.6% 1.02 [0.73~1.44] 0.9
Caucasian 7 0.61 0.0% 1.48 [0.95~2.29] 0.08
Asian 8 < 0.01 91.3% 1.31 [0.54~3.14] 0.55
CP 12 < 0.01 88.5% 1.24 [0.63~2.42] 0.54
AgP 4 0.35 9.5% 1.83 [0.82~4.12] 0.14

Figure 2

Forest plot for TT vs CC genotype comparison in subgroup analysis by ethnicity"

Figure 3

Egger’s funnel plot of IL -4 -590C/T polymorphysims and periodontitis （TT + CT） vs CC"

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