Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (9): 634-637.DOI: 10.12016/j.issn.2096-1456.2021.09.010

• Review Articles • Previous Articles     Next Articles

Research progress on nano-calcium phosphate modified dental materials for the prevention and treatment of dental pulp diseases

HUANG Yannan(),CHENG Lei()   

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-11-04 Online:2021-09-20 Published:2021-06-18
  • Contact: Lei CHENG
  • Supported by:
    National Natural Science Foundation of China(81870759)



  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科,四川 成都(610041)
  • 通讯作者: 程磊
  • 作者简介:黄彦楠,医师,硕士研究生,Email:
  • 基金资助:


Nanomaterials usually refer to tiny particles with a diameter of 1-100 nm, which often have unique physicochemical properties and are one of the main areas of research interest for development of dental biomaterials. Nano-calcium phosphate modified dental materials have been widely used in pit and fissure sealing, dental resin restoration, tooth adhesion, and root canal sealing. The current research shows that the dental material modified by nano-calcium phosphate has stronger mechanical properties and shows long-term calcium and phosphorus ion release and excellent ion recharging ability, which can promote the remineralization of tooth hard tissue and has good prospects for application. However, it is difficult to accurately simulate the complex environment of the oral cavity. Therefore, the biocompatibility, cytotoxicity and effect of clinical application of nano-calcium phosphate modified dental materials still needs further study. This review summarizes and discusses the recent research progress regarding nano-calcium phosphate modified dental materials in the prevention and treatment of dental pulp diseases.

Key words: nanometer calcium phosphate, dental materials, material modification, pit-and-fissure sealant, composite resin, resin adhesive, root canal sealant, dental decay, dental pulp disease, oral microorganisms


纳米材料通常是指直径1~100 nm的微小颗粒,往往具有独特的物理化学性质,是牙科生物材料发展的主要方向之一。纳米磷酸钙盐改性牙科材料在窝沟封闭、牙体树脂修复、牙体粘接、根管封闭等方面有广泛的应用。目前研究表明,纳米磷酸钙盐改性后的牙科材料具有更强的机械性能,还显示出钙磷离子长期释放和较好的离子再充能力,能够有效促进牙体硬组织再矿化,具有良好的应用前景。但目前研究难以准确模拟口腔内的复杂环境,因此,纳米磷酸钙盐改性牙科材料的生物相容性、细胞毒性及在临床运用的效果等仍需进一步验证。本文就近年来纳米磷酸钙盐改性牙科材料在牙体牙髓疾病防治方面研究的进展进行综述。

关键词: 纳米磷酸钙盐, 牙科材料, 材料改性, 窝沟封闭剂, 复合树脂, 树脂粘接剂, 根管封闭剂, 龋病, 牙髓病, 口腔微生物

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