Journal of Prevention and Treatment for Stomatological Diseases ›› 2021, Vol. 29 ›› Issue (9): 644-648.DOI: 10.12016/j.issn.2096-1456.2021.09.012

• Review Articles • Previous Articles    

The impact of masticatory dysfunction caused by occlusal disharmony on cognitive function

OU Yanzhen(),LI Baosheng,CAI Qing,JIANG Jiayang,JIN Zhuohua,MENG Weiyan()   

  1. Oral Implantology Department, School and Hospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun 130021, China
  • Received:2020-11-01 Online:2021-09-20 Published:2021-06-18
  • Contact: Weiyan MENG
  • Supported by:
    Natural Science Fund Project of Jilin Provincial Department of Science and Technology(20180101121JC);Science and Technology Project of Jilin Provincial Department of Finance(JCSZ2019378-3);Special Project of Jilin Provincial Development and Reform Commission for Industrial Technology Research and Development(2019C051-8)



  1. 吉林大学口腔医院种植科·吉林省牙发育及颌骨重塑与再生重点实验室,吉林 长春(130021)
  • 通讯作者: 孟维艳
  • 作者简介:欧燕珍,医师,硕士,Email:
  • 基金资助:


As the world’s population ages, age-related cognitive decline and dementia are becoming important challenges for geriatric care. Despite the ongoing search for solutions to address cognitive decline, effective interventions have not yet been established. There is increasing evidence from clinical, epidemiological, and animal studies that masticatory dysfunction due to occlusal disharmony is a risk factor for cognitive decline and an increased incidence of dementia. The mechanisms may involve altered nutritional intake, decreased cerebral blood flow, chronic stress, and hippocampal morphological function. These findings suggest that maintaining and adequately restoring the entire masticatory system has a positive impact for the prevention of cognitive decline.

Key words: occlusal disharmony, masticatory dysfunction, cognitive function, Alzheimer’s disease, hippocampus, hypothalamic-pituitary-adrenal axis, cerebral blood flow, chronic stress, nutrition



关键词: 咬合不协调, 咀嚼功能障碍, 认知功能, 阿尔兹海默症, 海马, HPA轴, 脑血流量, 慢性压力, 营养

CLC Number: